A5101492286- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Tryptophan and brain disorders
- Advanced machining processes and optimization
- Advanced Surface Polishing Techniques
- Biosensors and Analytical Detection
- Bone Metabolism and Diseases
- Sleep and related disorders
- Advanced Machining and Optimization Techniques
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Advanced MEMS and NEMS Technologies
- Stress Responses and Cortisol
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Advanced Nanomaterials in Catalysis
- Cancer-related Molecular Pathways
Commercial Aircraft Corporation of China (China)
2025
Xi'an Jiaotong University
2011-2024
Liaocheng People's Hospital
2017-2024
Chengdu University of Traditional Chinese Medicine
2022-2024
University of Electronic Science and Technology of China
2024
Guizhou University
2023
China Association of Agricultural Science Societies
2023
Guizhou Provincial Science and Technology Department
2023
China Tobacco
2022-2023
Jinan University
2010-2021
Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and reconstruction extracellular environment. Matrix (MVs) a type EVs released by bone-related functional cells, they participate mineralization. Here, we report bioinspired MVs embedded with black phosphorus (BP) functionalized cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The can direct to targeted increasing concentration inorganic phosphate originating...
Detection of biomarkers in complex samples is a significant health plan strategy for medical diagnosis, therapy monitoring, and management. However, high background noise resulting from impurities other analytes has hampered the improvement detection sensitivity accuracy. Herein, an ultralow biochip based on time-gated luminescent probes supported by photonic crystals (PCs) was successfully developed bladder cancer (BC)-related miRNA with specificity urine samples. Coupled luminescence...
Non-small cell lung carcinoma (NSCLC) metastasis is responsible for most of cancer-related mortality. The tumor associated macrophages (TAMs) are known to be crucial cells in cancer and usually divided into two antagonistic types, M1 M2. Puerarin has a wide spectrum pharmacological properties. present study explores puerarin on macrophage polarization NSCLC. results demonstrated that inhibited growth volumes NSCLC xenograft model, increased markers [CD197+, inducible nitric oxide synthase...
This review provides an in-depth understanding and introduces recent progress in the design applications of DNA nanomaterials which possess intriguing structures functions.
MicroRNA-34a (miR-34a) is a direct transcriptional target of p53, and downregulated in several different types cancer. However, the underlying mechanism miR-34a effects colorectal cancer not well understood. In this study, we explored role cell invasion, migration, apoptosis. Transient overexpression SW480 cells caused severe decrease migration invasion (both, p<0.05) compared to control groups. Combining transfection with 5-fluorouracil (5-FU) treatment further enhanced inhibition 5-FU...
Lysine lipoylation, a highly conserved lysine post-translational modification, plays critical role in regulating cell metabolism. The catalytic activity of number vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lipoylation. Despite its important roles, the detailed biological regulatory mechanism lipoylation remains largely unexplored. Herein we designed powerful affinity-based probe, KPlip, to interrogate interactions lipoylated peptide/proteins under native...
In the field of biomechanics, delicate structural layout living organisms often brings many inspirations for engineering design. As in case aero-engine piping layout, current single- and multi-tube layouts are ineffective need to be optimised. Inspired by efficient material transfer space utilisation mechanisms biological systems, we propose an automatic pipe method based on co-evolutionary algorithm improved A* algorithm. Taking inspiration from how networks adapt optimize their...
In high speed and precision machining applications, it is important to monitor the process in order ensure product quality. For this purpose, essential develop a dynamometer with sensitivity natural frequency which suited these conditions. This paper describes design, calibration performance of milling torque sensor based on piezoresistive MEMS strain. A detailed design study carried out optimize two mutually-contradictory indicators frequency. The developed principally consists thin-walled...
Nuclear factor- κB (NF- κB) plays a pivotal role in the regulation of immune and inflammatory responses. The real-time expression level NF- reflects development ulcerative colitis (UC). Polydatin has vast pharmacological activities, including inhibiting production mediators, inducing antioxidants, regulating function, etc. purpose this study was to investigate potential inhibitory effects polydatin on pathway activation mouse UC model. results showed that treatment downregulated p65 activity...
Background:Targeting Streptococcus mutans, the principle cariogenic bacterium, could prove to be an effective means of preventing dental caries. A de novo designed antimicrobial peptide, GH12, has shown bactericidal effects on S. mutans and inhibitory virulence regulatory systems mutans. However, GH12 caries remain elucidated.Objectives: The objectives this study were evaluate direct numbers mutansin vivo.Design: Keyes score was evaluated in a rodent model vivo quantified by qPCR. To further...
Gremlin has been reported to regulate inflammation and osteogenesis. Periodontitis is a destructive disease degenerating periodontal tissues, therefore leads alveolar bone resorption tooth loss. Based on the importance of Gremlin's bio-activity, aim this study to, in vivo vitro, unveil function regulating development periodontitis its consequent effects loss.Clinical specimens were used determine expression tissues by immunohistochemical staining western blot. Then utilizing rat model...
Abstract Background Emerging evidence supports the association between periodontitis and depression, although mechanisms are unclear. This study investigated role of SorCS2 in pathogenesis periodontitis‐induced depression. Materials Methods An experimental model was established using knockout mice their wild‐type littermates, depression‐like behaviour evaluated. The expression proBDNF signalling, neuronal activity, glutamate‐associated signalling pathways were further measured by western...
The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic (GFAP), brain-derived neurotrophic factor (BDNF), and cell line-derived (GDNF) change in patients with chronic insomnia disorder (CID), if is case, altered levels these are associated poor sleep quality cognitive decline CID.Fifty-seven CID outpatients constituted group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography,...
Background: Breast cancer is one of the most common cancers worldwide. Long non-coding RNAs and microRNAs act as important regulators in human cancers. This study aims to explore molecular mechanism among H19, miR-491-5p zinc finger 703 (ZNF703) breast cancer. Materials Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted detect expression ZNF703. Cell Counting Kit 8 (CCK-8) assay performed evaluate cell proliferation. apoptosis assessed by flow cytometry assay....