A5029166387- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nuclear Structure and Function
- RNA Research and Splicing
- Caveolin-1 and cellular processes
- Neuroscience and Neuropharmacology Research
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Effects and risks of endocrine disrupting chemicals
- Cancer, Hypoxia, and Metabolism
- Hearing, Cochlea, Tinnitus, Genetics
- Stress Responses and Cortisol
- Hip disorders and treatments
- Anesthesia and Neurotoxicity Research
- Antioxidants, Aging, Portulaca oleracea
- Photoreceptor and optogenetics research
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Microtubule and mitosis dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Infant Health and Development
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Cardiovascular Syncope and Autonomic Disorders
University of California, Los Angeles
2008-2024
Southwest Medical University
2017-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2018-2021
Chaohu Hospital of Anhui Medical University
2020
Hefei University of Technology
2014
In-Q-Tel
2014
Hefei University
2014
National Taiwan University
2008
Deficiencies in either lamin B1 or B2 cause both defective migration of cortical neurons the developing brain and reduced neuronal survival. The abnormality is explained by a weakened nuclear lamina that interferes with nucleokinesis, translocation process required for migration. In contrast, explanation impaired survival poorly understood. We hypothesized forces imparted on nucleus during result membrane (NM) ruptures, causing interspersion cytoplasmic contents-and ultimately cell death. To...
Apolipoprotein AV (APOA5) lowers plasma triglyceride (TG) levels by binding to the angiopoietin-like protein 3/8 complex (ANGPTL3/8) and suppressing its capacity inhibit lipoprotein lipase (LPL) catalytic activity ability detach LPL from sites within capillaries. However, sequences in APOA5 that are required for ANGPTL3/8 have never been defined. A clue identity of those was presence severe hypertriglyceridemia two patients harboring an mutation truncates 35 residues (“APOA5Δ35”). We found...
GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) transports across ECs to its site of action in capillary lumen. GPIHBP1's 3-fingered LU domain required for LPL binding, but function acidic (AD) has remained unclear. We created mutant mice lacking AD found severe hypertriglyceridemia. As expected, GPIHBP1 retained capacity bind LPL. Unexpectedly, however, most was located on abluminal...
Lipoprotein lipase (LPL), the enzyme that carries out lipolytic processing of triglyceride-rich lipoproteins (TRLs), is synthesized by adipocytes and myocytes secreted into interstitial spaces. The LPL then bound GPIHBP1, a GPI-anchored protein endothelial cells (ECs), transported across ECs to capillary lumen. assumption has been moved capillaries remains attached GPIHBP1 serves as platform for TRL processing. In current studies, we examined validity assumption. We found an LPL-specific...
GPIHBP1, a protein of capillary endothelial cells (ECs), is crucial partner for lipoprotein lipase (LPL) in the lipolytic processing triglyceride-rich lipoproteins. which contains three-fingered cysteine-rich LU (Ly6/uPAR) domain and an intrinsically disordered acidic (AD), captures LPL from within interstitial spaces (where it secreted by parenchymal cells) shuttles across ECs to lumen. Without remains stranded spaces, causing severe hypertriglyceridemia (chylomicronemia). Biophysical...
Why apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia has remained unclear, but we suspected that the underlying cause was reduced amounts of lipoprotein lipase (LPL) in capillaries. By routine immunohistochemistry, observed LPL staining heart and brown adipose tissue (BAT) capillaries Apoa5–/– mice. Also, after an intravenous injection LPL-, CD31-, GPIHBP1-specific monoclonal antibodies, binding antibodies to BAT (relative CD31 or GPIHBP1 antibodies) levels postheparin plasma...
Lipoprotein lipase (LPL) is secreted into the interstitial spaces by parenchymal cells and then transported capillaries GPIHBP1. LPL carries out lipolytic processing of triglyceride (TG)-rich lipoproteins (TRLs), but tissue-specific regulation incompletely understood. Plasma levels TG hydrolase activity after heparin injection are often used to draw inferences about intravascular levels, validity these unclear. Moreover, plasma not helpful for understanding in specific tissues. Here, we...
The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic (GFAP), brain-derived neurotrophic factor (BDNF), and cell line-derived (GDNF) change in patients with chronic insomnia disorder (CID), if is case, altered levels these are associated poor sleep quality cognitive decline CID.Fifty-seven CID outpatients constituted group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography,...
The lipolytic processing of triglyceride (TG)-rich lipoproteins in the heart is regulated by feeding status. In 1988, Kuwajima et al. (1Kuwajima M. Foster D.W. McGarry J.D. Regulation lipoprotein lipase different rat tissues.Metabolism. 1988; 37: 597-601Abstract Full Text PDF PubMed Scopus (34) Google Scholar) found that amount TG hydrolase activity released from during a heparin infusion greater fasting than after refeeding, but whether observed changes reflected amounts (LPL) inside blood...
Based on Wnt signaling pathway, this study aims to further mechanistically understand memory alteration after BPA exposure.
To support in vivo and vitro studies of intravascular triglyceride metabolism mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 31A5, were used to develop a sandwich ELISA for The detection LPL by the was linear concentrations ranging from 0.31 ng/ml 20 ng/ml. sensitivity made it possible quantify serum both pre-heparin post-heparin plasma samples (including grossly lipemic samples). mass activity levels lower Gpihbp1−/− mice than wild-type mice. In...
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component nuclear lamina. In absence ZMPSTE24, accumulates in nucleus and exerts toxicity, causing variety disease phenotypes. By ∼4 months age, both male female Zmpste24−/− mice manifest near-complete loss adipose tissue, but it has never been clear whether this phenotype direct consequence toxicity adipocytes. To address question, we generated conditional knockout Zmpste24...
Significance Deficiencies or defects in nuclear lamins result cell toxicity and cause multiple human diseases. Nuclear membrane (NM) ruptures have been implicated both disease pathogenesis, but the factors that modulate susceptibility to NM are unknown. We observed low levels of LAP2β, a chromatin-tethering inner protein, lamin–deficient neurons fibroblasts with frequent ruptures. Further reducing LAP2β expression markedly increased (without affecting rupture duration), whereas increasing...
Objective: To explore the effects and clinical significance of mental state on SSNHL. Design: Cross-sectional study. Setting: Teaching-hospital otolaryngology. Participants: Otolaryngology inpatient with Main outcome measures: Mental in pre- post-treatment was evaluated by SCL-90, severity tinnitus acquired THI. Moreover, correlations between classification, prognosis, degree, different occupation, age were analyzed. Results: 115 patients There significant differences depression（F=5.46,...
Lipoprotein lipase (LPL) and multiple regulators of LPL activity (e.g., APOC2 ANGPTL4) are present in all vertebrates, but GPIHBP1-the endothelial cell (EC) protein that captures within the subendothelial spaces transports it to its site action capillary lumen-is mammals not chickens or other lower vertebrates. In mammals, GPIHBP1 deficiency causes severe hypertriglyceridemia, maintain low triglyceride levels despite absence GPIHBP1. To understand intravascular lipolysis we examined...
The spindle assembly checkpoint (SAC) is an indispensable guardian machinery for cell mitotic progression, which ensures the successful alignment of chromosomes on metaphase plate before / anaphase transition．This anomaly closely related to tumorigenesis. Monopolar kinase 1 (Mps1) a conserved bispecific protein whose main function central replication and activation SAC, both contribute prevention mitosis prevent tumor occur. Recent studies have found that Mps1 expression level associated...
Salivary exosomes are round cup-shaped vesicles produced by cells through active secretion and excreted extracellularly. They contain a large number of information molecules, participate in regulate various signal pathways, play an extremely important role exchange substance transfer between cells. can be used not only as markers for disease diagnosis, but also drug carriers the treatment diseases. This article reviews current research progress salivary their head neck malignant...