A5086134325- RNA Research and Splicing
- Meat and Animal Product Quality
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- RNA and protein synthesis mechanisms
- Fermentation and Sensory Analysis
- Ubiquitin and proteasome pathways
- Advanced Chemical Sensor Technologies
- CRISPR and Genetic Engineering
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Genome Rearrangement Algorithms
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Enzyme Catalysis and Immobilization
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Yeasts and Rust Fungi Studies
- Sirtuins and Resveratrol in Medicine
- Wnt/β-catenin signaling in development and cancer
- Constraint Satisfaction and Optimization
Liaocheng University
2025
Zhejiang University
2024
Ludong University
2023-2024
Guangdong Medical College
2024
First People's Hospital of Yunnan Province
2024
Kunming University of Science and Technology
2024
Guangdong Academy of Agricultural Sciences
2021-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Hebei Agricultural University
2023-2024
General Hospital of Shenyang Military Region
2014-2024
Abstract Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including super-enhancers in different breast subtypes remains poorly characterized. Triple-negative (TNBC) an aggressive subtype with poor prognosis. Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between subtypes, provide clinically relevant biological insights towards TNBC. Using...
Histone deacetylases (HDACs) function in a wide range of molecular processes, including gene expression, and are significant interest as therapeutic targets. Although their native complexes, subcellular localization, recruitment mechanisms to chromatin have been extensively studied, much less is known about whether the enzymatic activity non-sirtuin HDACs can be regulated by natural metabolites. Here, we show that several coenzyme A (CoA) derivatives, such acetyl-CoA, butyryl-CoA, HMG-CoA,...
Repeated infection with high-risk HPV is a major cause for the development and metastasis of human cervical cancer, even though mechanism still not completely understood. Here, we reported that miR-218 (microRNA-218) was downregulated in cancer tissues, especially metastatic tissues. We found expression associated clinicopathological characteristics patients cancer. MiR-218 overexpression inhibited Epithelial-Mesenchymal Transition (EMT), migration invasiveness cells vitro. Moreover,...
The development of efficient adsorbents for the removal organophosphorus pesticides from water is a major challenge. In this work, we prepared an activated carbon derived sieve-like cellulose/graphene oxide composites (ACCE/G) several pesticides. We employed corn straw to produce cellulose-graphene composite (CCE/G); then, by treating CCE/G with potassium hydroxide at high temperatures, adsorbent ACCE/G was prepared. adsorption capacity higher than those other sorbents, including multi-wall...
The abundance of core Wnt/PCP protein Vangl is regulated by the endoplasmic reticulum–associated degradation (ERAD) pathway.
Abstract HECT E3 ligases control the degradation and functioning of numerous oncogenic/tumor-suppressive factors signaling proteins, their activities must be tightly regulated to prevent cancers other diseases. Here we show that Nedd4 family WWP1 adopts an autoinhibited state, in which its multiple WW domains sequester using a multi-lock mechanism. Removing WW2 or WW34 led partial activation WWP1. The structure fully inhibited reveals many mutations identified cancer patients result...
Lysine lipoylation, a highly conserved lysine post-translational modification, plays critical role in regulating cell metabolism. The catalytic activity of number vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lipoylation. Despite its important roles, the detailed biological regulatory mechanism lipoylation remains largely unexplored. Herein we designed powerful affinity-based probe, KPlip, to interrogate interactions lipoylated peptide/proteins under native...
CLIP-170 is a microtubule-binding protein and participates in diverse microtubule-associated cellular activities by regulating microtubule dynamics. Here we provide evidence that mediator of the sensitivity anti-microtubule drug paclitaxel breast cancer. In vitro cell proliferation assays reveal expression cancer lines correlates with their to paclitaxel. addition, clinical samples pathological response tumours paclitaxel-containing chemotherapy. Mitotic index caspase-3 activity analyses...
Abstract Background Aberrant activation of the phosphatidlinositol 3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR) signaling pathway has been shown to play an important role in lung adenocarcinoma (LUAD). The effect KRAS mutations, one signatures LUAD, on PI3K/AKT/mTOR LUAD remains unclear. Methods Seurat package and principal component analysis were used for cell categorization single‐cell RNA sequencing data LUAD. AUCell score was assess activity pathway....
Piceatannol (PIC) is confirmed to inhibit the proliferation of various tumors, but its role in osteosarcoma still remains unknown. This study investigated function PIC osteosarcoma, aiming provide a research basis for therapy.Human cells this were, respectively, treated with at concentrations (0, 20, 40, 80 μmol/L), PI3K/AKT/mTOR pathway inhibitor (LY294002), or activator (740Y-P) plus PIC. Osteosarcoma were subcutaneously injected into nude mice establish xenograft models, and was...
Background. Cervical cancer (CC) is a common gynecological malignant tumor. Ferroptosis new type of programmed cell death, which plays crucial part in cancer. However, current knowledge regarding ferroptosis-related long noncoding RNAs (lncRNAs) CC still limited. Therefore, our aim to identify lncRNAs, build steady prediction model, and improve the value CC. Methods. We obtained RNA expression gene data female patients from TCGA FerrDb databases, respectively. Then, lncRNAs were by limma R...