A5053219276- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Electrolyte and hormonal disorders
- GABA and Rice Research
- Bioactive Compounds and Antitumor Agents
- Nanoparticles: synthesis and applications
- Cancer Cells and Metastasis
- Bacterial biofilms and quorum sensing
- Malaria Research and Control
- Plant responses to water stress
- Single-cell and spatial transcriptomics
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Kruppel-like factors research
- Bioeconomy and Sustainability Development
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Computational Drug Discovery Methods
- Genomics and Chromatin Dynamics
- Respiratory and Cough-Related Research
City University of Hong Kong
2021-2024
Ahmadu Bello University
2024
University of the Punjab
2017-2019
Centre of Excellence in Molecular Biology
2019
Hamad bin Khalifa University
2019
Abstract Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including super-enhancers in different breast subtypes remains poorly characterized. Triple-negative (TNBC) an aggressive subtype with poor prognosis. Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between subtypes, provide clinically relevant biological insights towards TNBC. Using...
ANLN is frequently upregulated in triple-negative breast cancer (TNBC) and its high expression tumors are significantly associated with poor survival recurrence, thereby it has been proposed to function as a prognostic marker for cancer. However, the specific molecular mechanisms by which promotes TNBC tumorigenesis remain elusive. Using multiomic profiling, we recently uncovered TNBC-specific gene driven super-enhancer. Here, Crispr/Cas9 editing, showed that knockout of inhibits spheroid...
Abstract Triple‐negative breast cancer (TNBC) remains a significant challenge in terms of treatment, with limited efficacy chemotherapy due to side effects and acquired drug resistance. In this study, threose nucleic acid (TNA)‐mediated antisense approach is employed target therapeutic Akt genes for TNBC therapy. Specifically, two new TNA strands (anti‐Akt2 anti‐Akt3) are designed synthesized that specifically Akt2 Akt3 mRNAs. These TNAs exhibit exceptional enzymatic resistance, high...
To investigate the relationship of 3 single nucleotide polymorphism (SNP) variants ADAM33 with asthma susceptibility in patients from Northern and Central Punjab, Pakistan. Methods: In this case-control study, healthy asthmatic participants were recruited between 2015 2017. The SNPs gene, rs2280089, rs2280090, rs2280091 analyzed 296 343 controls, as well linkage disequilibrium haplotype analysis.The non-significant differences observed allele genotype frequencies persons even after...
Aspartame is a low calorie sugar that widely used in artificial sweeteners.Although different studies indicated associated health symptoms to it, it continues be controversial.Studies have also shown consumption of aspartame caused neurological deficits and mitochondrial mediated activation apoptosis was observed as long-term effect rat brain.In this study, the biochemical responses distal tubular kidney cells upon short-term exposure were measured.MDCK Type II (kidney) exposed 50 µg/ml 250...