A5009465540- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Molecular Junctions and Nanostructures
- Luminescence and Fluorescent Materials
- Diamond and Carbon-based Materials Research
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Photochromic and Fluorescence Chemistry
- Analytical Chemistry and Sensors
- Supramolecular Chemistry and Complexes
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Organic Electronics and Photovoltaics
- X-ray Diffraction in Crystallography
- Organic Light-Emitting Diodes Research
- Crystallization and Solubility Studies
- Conducting polymers and applications
- Molecular Sensors and Ion Detection
- Synthesis and Properties of Aromatic Compounds
- Graphene and Nanomaterials Applications
- Microfluidic and Bio-sensing Technologies
- Chemistry and Chemical Engineering
- Plasmonic and Surface Plasmon Research
- Nonlinear Optical Materials Studies
City University of Hong Kong, Shenzhen Research Institute
2016-2025
City University of Hong Kong
2016-2025
Kowloon Hospital
2018-2021
Laboratoire de Chémo-biologie synthétique et thérapeutique
2015
Université de Strasbourg
2015
Centre National de la Recherche Scientifique
2015
McGill University
2008-2012
Hong Kong Baptist University
2005-2012
University of Bologna
2011
Nanjing University
2006
Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous nanoparticles, the quantum yield, luminescence lifetime, intensity Ru(bpy)32+ guest molecules much improved owing to steric confinement effect MOF pores. Benefiting from...
Conjugated polymers synthesized by step polymerization mechanisms typically suffer from poor molecular weight control and broad distributions. We report a new method which uses nucleobase recognition to read out efficiently copy the controlled chain length narrow distribution of polymer template generated living polymerization, into daughter conjugated polymer. Aligning nucleobase-containing monomers on their complementary parent using hydrogen-bonding interactions, subsequently carrying...
Abstract This study reports biosensing using graphene field‐effect transistors with the aid of pyrene‐tagged DNA aptamers, which exhibit excellent selectivity, affinity, and stability for Escherichia coli ( E. ) detection. The aptamer is employed as sensing probe due to its advantages such high affinity toward small molecules even whole cells. change carrier density in probe‐modified attachment discussed theoretically first time also verified experimentally. conformational binding brings...
We demonstrate a nanotechnology approach for the development of cancer-cell-specific subcellular organelle-targeted drug nanocarriers based on photostable nanodiamonds (ND) functionalized with folic acid and mitochondrial localizing sequence (MLS) peptides. showed that these multifunctional NDs not only distinguish between cancer cells normal cells, transport loaded drugs across plasma membrane but also selectively deliver them to mitochondria induce significant cytotoxicity cell death...
In this paper, we report on the synthesis and properties of a novel series multi-triarylamine-substituted carbazole-based dendrimers G2-OTP(n)-G2 (n = 2−5) with an oligothiophene core. The length core varied from 2 to 5 thiophene units. It was found that both absorption fluorescence emission peaks red-shifted increasing length. As result, power conversion efficiencies as-fabricated solar cells using composite these PCBM as photoactive layer increased length, 0.04% for G2-DTP-G2 0.13%...
We demonstrate an all-optical method for magnetic sensing of individual molecules in ambient conditions at room temperature. Our approach is based on shallow nitrogen-vacancy (NV) centers near the surface a diamond crystal, which we use to detect single paramagnetic covalently attached surface. The manipulation and readout NV provides sensitive probe field fluctuations stemming from dynamics electronic spins molecules. As specific example, detection molecule containing gadolinium (Gd$^{3+}$)...
Correlative light and electron microscopy promises to combine molecular specificity with nanoscale imaging resolution. However, there are substantial technical challenges including reliable co-registration of optical images rapid signal degradation under beam irradiation. Here, we introduce a new approach solve these problems: stable cathodoluminescence emitted in scanning microscope by nanoparticles controllable surface chemistry. We demonstrate well-correlated secondary using three species...
Novel biocompatible cyanines show not only a very large two-photon cross-section of up to 5130 GM at 910 nm in aqueous medium for high-contrast and -brightness fluorescence live cell imaging but also highly selective subcellular localization properties including mitochondria lysosomes.
We have demonstrated that the subcellular targeting properties of indole-based cyanines can be tuned by functional substituent attached onto indole moiety in which first example a highly RNA-selective and two-photon active fluorescent light-up probe for high contrast brightness TPEF images rRNA nucleolus live cells has been developed. It is important to find this cyanine binds much stronger toward RNA than DNA buffer solution as well selectively stains targets nucleolus. Remarkably, (Φσmax)...
The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death. Cell free-double strand DNA (dsDNA) segments from tissue debris are engulfed by microglia and sensed their cyclic GMP-AMP synthase (cGAS), which triggers robust activation of the innate immune stimulator interferon genes (STING) pathway initiate chronic inflammatory cascade. decomposition immunogenic dsDNA inhibition STING synergistic immunologic targets for ameliorating neuroinflammation. To...
The chair-type G-quadruplex structure formed by human telomeric variant DNA.
Abstract Stimuli‐responsive DNA‐based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These exploit unique properties DNA molecules to perform programmable computational operations in response specific stimuli. This review provides comprehensive overview recent advancements design, working principles, applications stimuli‐responsive gates. The progress made developing various types triggered by metal ions, pH, oligonucleotides, small...
Abstract Objectives Detecting point mutations with high sensitivity and specificity can be technically very challenging, but it is crucial for early diagnosis effective drug treatment of cancers. To enable ultrasensitive ultraspecific detection single-base in simple economical ways, we have developed an artificial base mismatches-mediated PCR (ABM-PCR) approach. Methods ABM-PCR was applied to quantitative (qPCR) droplet digital (ddPCR) platforms. The impact mismatches on the thermodynamic...
Developing aptasensors offers several advantages including sensitivity, selectivity, cost-effectiveness, and speed over traditional analytical techniques for antibiotic detection. We have successfully identified Enro_ap3, a 30-mer enrofloxacin-binding aptamer with micromolar binding affinity, through an optimized Capture-SELEX platform. Compared to other reported aptamers, this shorter not only streamlines the design process but also eliminates common issue of strong nonspecific GO surface,...
We report a DNA-templated approach to construct nanotubes with controlled lengths and narrow molecular weight distribution, allowing the deliberate variation of this length. This relies on facile modular assembly DNA guide strand precise length that contains single-stranded gaps repeating at every 50 nm. is followed by positioning triangular "rungs" each these adding identical linking strands two other sides triangles close nanotubes. The can be deliberately changed. show use produce 1 μm or...
Peptide-functionalized DNA nano-objects selectively target mitochondria and the nucleus by means of nanoneedle-assisted delivery. This technology preserves cell viability structural integrity nanostructures assists in escaping degradation endocytosis. method opens up a new avenue for further vitro studies intracellular behaviors assemblies their interactions specific organelles.