A5032329035- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Non-Invasive Vital Sign Monitoring
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Minerals Flotation and Separation Techniques
- Antimicrobial Peptides and Activities
- Supercapacitor Materials and Fabrication
- Molecular Sensors and Ion Detection
- Nanocluster Synthesis and Applications
- Advancements in Battery Materials
- Nanowire Synthesis and Applications
- Nanomaterials for catalytic reactions
- Polydiacetylene-based materials and applications
- ECG Monitoring and Analysis
- Graphene research and applications
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Carbon Nanotubes in Composites
- nanoparticles nucleation surface interactions
- Cardiovascular and exercise physiology
- Piperaceae Chemical and Biological Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Cardiovascular Health and Disease Prevention
City University of Hong Kong
2015-2021
Kowloon Hospital
2021
City University of Hong Kong, Shenzhen Research Institute
2019
Technical Institute of Physics and Chemistry
2019
Karunya University
2015
Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous nanoparticles, the quantum yield, luminescence lifetime, intensity Ru(bpy)32+ guest molecules much improved owing to steric confinement effect MOF pores. Benefiting from...
Abstract Hypoxic microenvironment severely reduces therapeutic efficacy of oxygen‐dependent photodynamic therapy in solid tumor due to the hampered cytotoxic oxygen radicals generation. Herein, a biocompatible nanoparticle (NP) is developed by combining bovine serum albumin, indocyanine green (ICG), and an oxygen‐independent generator (AIPH) for efficient sequential cancer therapy, denoted as BIA NPs. Upon near‐infrared irradiation, photothermal effect generated ICG will induce rapid...
To make nanomedicine potentially applicable in a clinical setting, several methods have been developed to synthesize pure nanodrugs (PNDs) without using any additional inert carriers. In this work, we report novel green, low-cost, and scalable ice-template-assisted approach which shows unique characteristics. First, the whole process only requires adding drug solution into an ice template subsequent melting (or freeze-drying), allowing easy industrial mass production with low capital...
Tumor hypoxia is a noteworthy impediment to effective photodynamic therapy (PDT), as it would sharply weaken the effectiveness of oxygen-dependent PDT. To enable PDT in both well normoxia circumstances, here, we report multifunctional nanoreactor (C3N4/MnO2 NPs), which guarantees type-II (oxygen-dependent) by situ oxygen generation via Fenton reaction. In addition, C3N4/MnO2 NPs can also be used for oxygen-independent type-I evolving cytotoxic hydroxyl radical reduce reliance on...
Abstract Near‐infrared (NIR) organic photodetectors (OPDs), particularly all‐polymer‐based ones, hold substantial commercial promise in the healthcare and imaging sectors. However, process of optimizing their active layer composition to achieve highly competitive figures merit lacks a clear direction methodology. In this work, celebrity polymer acceptor PY‐IT into more NIR absorbing host system PBDB‐T:PZF‐V, significantly enhance photodetection competence, is introduced. The refined...
Although piperine-an extract from pepper-has a mild chemotherapeutic effect, its poor water solubility has limited applications for cancer therapy. With self-assembling of piperine into nanoparticles along with PEG (Pip NPs), both the dispersibility and efficacy can be substantially enhanced. It is further shown that NPs generate reactive oxygen species (ROS) or without additional white light irradiation. Interestingly, Pip NP induced cell death suppressed by ferroptosis inhibitors such as...
Molecular nanomedicine (BthB NPs) is developed for effective superoxide radical (O<sub>2</sub>˙<sup>−</sup>) generation hypoxia-overcoming photodynamic therapy (PDT), upon irradiation with an 808 nm laser a high tissue penetration depth.
Polymer dots (Pdots) have emerged as a new type of fluorescent probe material for biomedical applications and attracted great interest due to their excellent optical properties biocompatability. In this work, we report on red-emitting P3HT Pdot intracellular bioimaging. The as-prepared exhibits good stability has large Stokes shift (121 nm) compared molecules in tetrahydrofuran (THF). Furthermore, the shows low cytotoxicity, broad absorption spectrum, resistance against photodegradation,...
In recent years, the use of accelerometer data in biosensors, which tracks physical activity levels and mobility, has gained more attention. Accelerometers offer enormous promise field blood pressure measurement addition to being utilized for monitoring. It is possible utilize it as a sensor measure ballistocardiograms (BCG) seismocardiograms (SCG), can be used forecast pressure. Accelerated plethysmograms also monitored real-time with accelerometer-based devices. More importantly,...
Accurate blood pressure (BP) prediction is pivotal for effective cardiovascular health management. This study introduces a deep learning model that utilizes electrocardiogram (ECG) and photoplethysmogram (PPG) signals BP predictions. Data from 16 subjects were collected. Utilizing long-term recurrent convolutional network, the mean absolute error (MAE) achieved was 10.7±10.6 mmHg systolic (SBP) 8.5±8.7 diastolic (DBP). These results underscore constraints imposed by small dataset size....
In article number 1903436, Jinfeng Zhang, Chun-Sing Lee, and co-workers develop a biocompatible free radicals nanogenerator for efficient hypoxic tumor therapy. This nanosystem can produce cytotoxic under laser irradiation-induced hyperthermia in both normoxia hypoxia to eradicate cancer cells. Meanwhile, high drug loading ability real-time release monitoring confers on the multifunctionality therapeutic performance.