A5100453645- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Neonatal Respiratory Health Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- Hormonal and reproductive studies
- Peroxisome Proliferator-Activated Receptors
- Diabetic Foot Ulcer Assessment and Management
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Research in Cotton Cultivation
- Plant Virus Research Studies
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Education
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Digestive system and related health
- Prostate Cancer Treatment and Research
Shantou University
2025
Xuzhou Medical College
2013-2023
Bristol-Myers Squibb (United States)
2023
Jiujiang University
2020
AstraZeneca (United States)
2019
South China Agricultural University
2018
Third Hospital of Hebei Medical University
2018
Hebei Medical University
2018
Renji Hospital
2017
Eli Lilly (United States)
2014-2016
Abstract Context Cotadutide is a dual receptor agonist with balanced glucagon-like peptide-1 and glucagon activity. Objective To evaluate different doses of cotadutide investigate underlying mechanisms for its glucose-lowering effects. Design/setting Randomized, double-blind, phase 2a study conducted in 2 cohorts at 5 clinical trial sites. Patients Participants were 65 adult overweight/obese patients type diabetes mellitus; 63 completed the study; withdrawn due to AEs. Intervention...
The methanolic extract from the roots and stems of Indian Salacia prinoides its water-eluted fraction Diaion HP-20 column were found to exhibit inhibitory activities against α-glucosidase.From fraction, two new unique constituents with thiosugar sulfonium sulfate, salaprinol (1) ponkoranol (2), isolated together 10 known including salacinol kotalanol.The structures 1 2 elucidated on basis
Luteolin (Lut) is a common dietary flavonoid present in Chinese herbal medicines that has been reported to have important anti-inflammatory properties. The purposes of this study were observe the inhibition lipopolysaccharide (LPS)-induced inflammatory responses bone marrow macrophages (BMM) by Lut, and examine whether involves p38/MK2/TTP-mediated mRNA stability. Lut suppressed production tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6) dose-dependent manner according enzyme-linked...
Abstract Objectives Detecting point mutations with high sensitivity and specificity can be technically very challenging, but it is crucial for early diagnosis effective drug treatment of cancers. To enable ultrasensitive ultraspecific detection single-base in simple economical ways, we have developed an artificial base mismatches-mediated PCR (ABM-PCR) approach. Methods ABM-PCR was applied to quantitative (qPCR) droplet digital (ddPCR) platforms. The impact mismatches on the thermodynamic...
Background: Radiofrequency ablation (RFA) is a relatively new procedure for treating benign thyroid nodules. The purpose of this study was to evaluate the safety and efficacy RFA nodules so as serve reference future clinical practice. Methods: This retrospectively analyzed data patients receiving percutaneous from November 2014 July 2015 in our medical center. One hundred eight with total 380 received ultrasound-guided Comparisons volume change before after treatment, post-treatment...
Peptide deformylase (PDF) is a metalloprotease catalyzing the removal of formyl group from newly synthesized proteins, which makes it an important antibacterial drug target. Given importance PDF inhibitors like actinonin in discovery, several reported potent were used to develop pharmacophore models using Galahad module Sybyl 7.1 software. Generated composed two donor atom centers, four acceptor centers and hydrophobic groups. Model-1 was screened against Zinc database compounds retrieved as...
Diabetes mellitus is a n arising public health concern, and diabetic foot one of the most common complications diabetes. Current management for cannot reach optimal remission. In this study, we aim to explore mechanism underlying pathogenesis provide novel strategies treatment foot. A total 10 normal skin tissues 20 ulcer specimens are collected. Cell proliferation determined by CCK-8 assay. cycle flow cytometry, cell senescence evaluated β-galactosidase staining. Co-immunoprecipitation...
What is known and objective Exenatide widely used in the treatment of type 2 diabetes mellitus (T2DM) because its established effect on lowering glucose promotion weight loss. However, therapeutic response to exenatide varies considerably among patients with T2DM. The purpose this study was determine which variables can predict individualize specific therapies for T2DM who need exenatide. Methods This a retrospective cohort were treated twice daily as part their care at least 12 months....
c-Myc is a major oncogene that estimated to result in almost all human cancers and the downregulation has become an attractive strategy for cancer treatment. For it hard design compounds can directly interact with protein, DNA G-quadruplex (G4) was discovered its promoter region which referred as potential drug target controlling expression. In this study, combined of molecular docking-based virtual screening, dynamics (MD) simulation, mechanics/generalized Born surface area (MM/GBSA) free...
Study Objective To investigate the associations of NOS 1 AP rs12742393 polymorphism with risk type 2 diabetes mellitus (T2 DM ) and repaglinide therapeutic efficacy in Chinese patients T2 . Design Prospective case‐control study. Setting Academic medical center. Patients A total 300 200 healthy volunteers were enrolled to identify genotypes using polymerase chain reaction–restriction fragment length assay. Eighty‐four various randomly selected receive oral as a single‐agent therapy (3 mg/day)...
Cardiovascular disease is the leading cause of morbidity and mortality in people with type 2 diabetes. MEDI4166 a proprotein convertase subtilisin/kexin 9 (PCSK9) antibody glucagon-like peptide-1 (GLP-1) analogue fusion molecule designed to treat patients diabetes who are at risk for cardiovascular disease. In this completed, first-in-human study, we evaluated safety efficacy single or multiple doses participants phase 1 study that was conducted across 11 clinics USA, eligible adults had...
The occurrence of benign prostate hyperplasia (BPH) was related to disrupted sex steroid hormones, and metformin (Met) had a clinical response hormone-related gynaecological disease. However, whether Met exerts an antiproliferative effect on BPH via hormones remains unclear. Here, our study showed that along with prostatic epithelial cell (PEC) proliferation, were dysregulated in the serum patients. As major contributor elevated DHT significant positive relationship characteristics...
Human peptide deformylase (HsPDF) is an important target for anticancer drug discovery. In view of the limited HsPDF, inhibitors were reported, and high-throughput virtual screening (HTVS) studies based on HsPDF developing new PDF remain to be reported. We reported here diverse small molecule with excellent activities designed HTVS molecular docking using crystal structure HsPDF. The compound M7594_0037 exhibited potent against HeLa, A549 MCF-7 cell lines IC50s 35.26, 29.63 24.63 μM,...
Background Exenatide is a GLP-1R agonist that often exhibits considerable interindividual variability in therapeutic efficacy. However, there no evidence about the impact of genetic variants PPARD on efficacy exenatide. This research was aimed to explore influence gene polymorphism effect exenatide, and identify potential mechanism futher. Methods A total 300 patients with T2DM 200 control subjects were enrolled rs2016520 rs3777744 genotypes. prospective clinical study used collect...
It has been shown that IGF-1 secretion is influenced by dietary protein or amino acid. However, whether the dipeptides elicit regulatory effects on remains largely unclear. Thus, this study aimed to investigate of dipeptide Pro-Gly expression and in HepG2 cells mice, explore underlying mechanisms. The vitro results indicated Pro-Gly, but not Pro plus Gly, promoted HepG2. Meanwhile, peptide transporter 1 (PepT1) was elevated whereas knockdown PepT1 with siRNA eliminated increase induced...
Abstract Previous pharmacogenomic studies of oral anti-diabetic drugs have primarily focused on the effect a single site. This study aimed to examine joint effects multiple loci repaglinide or rosiglitazone efficacy in newly diagnosed type 2 diabetes mellitus (T2DM) patients. A total 209 T2DM patients were randomly assigned treatment with for 48 weeks. The reductions fasting glucose (ΔFPG), 2h (Δ2hPG) and glycated hemoglobin (ΔHbA1c) levels significantly associated genetic score that was...
Abstract Background Genetic polymorphisms in the PPARD and NOS1AP is associated with type 2 diabetes mellitus (T2DM); however, there no evidence about its impact on therapeutic efficacy of nateglinide. This study was designed to investigate a potential association rs2016520 (T/C) rs12742393 (A/C) nateglinide newly diagnosed Chinese patients (T2DM). Methods Sixty T2DM were enrolled identify genotypes using polymerase chain reaction-restriction fragment length polymorphism assay (PCR–RFLP)....
LPIN1 is a Mg(2+)-dependent phosphatidic acid phosphatase. Variation in chicken exon 6 and its flanking regions were identified three indel variants breeds their associations with performance traits studied. Seven detected from breeds, which contained synonymous tri-allelic variant (c.924A/T/C) indels. The conserved among bird species. variation frequency presented clear differences breeds. Two coding indels (c.1014-1018del3 c.1125-1138del12) multiples of nucleotides maintained the open...
Background: MEDI0382 is an oxyntomodulin-like peptide with targeted GLP-1/glucagon receptor activity under development for type 2 diabetes mellitus (T2DM). GLP-1 and glucagon promote delayed gastric emptying, tolerance has been described. Methods: This exploratory part of a double-blind phase 2a study measured emptying time (GET) in T2DM patients randomized to daily SC (n = 20) or placebo 6) 49 days. Doses were up-titrated fortnightly from 50 300 µg. GET was after 13C-octanoate ingestion via...