Matthew J. O’Brien

ORCID: 0000-0001-8882-9865
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About
Contact & Profiles
Research Areas
  • Diabetes Management and Education
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Diabetes Management and Research
  • Obesity and Health Practices
  • Diabetes Treatment and Management
  • Cardiovascular Health and Risk Factors
  • Pleistocene-Era Hominins and Archaeology
  • Food Security and Health in Diverse Populations
  • Archaeology and ancient environmental studies
  • Irish and British Studies
  • Chronic Disease Management Strategies
  • Primary Care and Health Outcomes
  • Obesity, Physical Activity, Diet
  • Pharmacology and Obesity Treatment
  • Health disparities and outcomes
  • Pharmaceutical Practices and Patient Outcomes
  • Nutritional Studies and Diet
  • Homelessness and Social Issues
  • Metabolism, Diabetes, and Cancer
  • Physical Activity and Health
  • Pregnancy and preeclampsia studies
  • Medication Adherence and Compliance
  • Diet and metabolism studies
  • Forensic Anthropology and Bioarchaeology Studies
  • Public Health Policies and Education

Northwestern University
2016-2025

University of Chicago
2023-2025

University of Wisconsin–Madison
2022-2025

California State University, Chico
2017-2024

Northwestern Memorial Hospital
2024

Becton Dickinson (United States)
2023

University of Illinois Chicago
2021-2022

Franciscan University of Steubenville
2011-2022

Loyola University Chicago
2021

University of North Carolina at Chapel Hill
2021

<h3>Importance</h3> Gestational diabetes is associated with adverse maternal and offspring outcomes. <h3>Objective</h3> To determine whether rates of gestational among individuals at first live birth changed from 2011 to 2019 how these differ by race ethnicity in the US. <h3>Design, Setting, Participants</h3> Serial cross-sectional analysis using National Center for Health Statistics data 12 610 235 aged 15 44 years singleton births <h3>Exposures</h3> stratified following groups:...

10.1001/jama.2021.7217 article EN JAMA 2021-08-17

<h3>Importance</h3> Understanding cardiovascular outcomes of initiating second-line antidiabetic medications (ADMs) may help inform treatment decisions after metformin alone is not sufficient or tolerated. To date, no studies have compared the effects all major ADMs during this early decision point in pharmacologic management type 2 diabetes. <h3>Objective</h3> examine association ADM classes with adverse events. <h3>Design, Setting, and Participants</h3> Retrospective cohort study among 132...

10.1001/jamanetworkopen.2018.6125 article EN cc-by-nc-nd JAMA Network Open 2018-12-21

The 100% oxygen (O(2)) technique has been used to detect and quantify right-to-left shunt for more than 50 years. goal of this study was determine if breathing O(2) affected intrapulmonary arteriovenous pathways during exercise. Seven healthy subjects (3 females) performed two exercise protocols. In Protocol I an incremental cycle ergometer test (60 W + 30 W/2 min; room air, FIO2 = 0.209) shunting evaluated using saline contrast echocardiography at each stage. Once significant documented...

10.1113/jphysiol.2008.159350 article EN The Journal of Physiology 2008-08-08

Background Given the increasing prevalence of diabetes mellitus (DM) in United States, estimating effects population-level increases obesity on incident DM has substantial implications for public health policy. Therefore, we determined population attributable fraction, which accounts and excess risk associated with obesity. Methods Results We included non-Hispanic White, Black, Mexican American participants without at baseline from MESA (Multi-Ethnic Study Atherosclerosis) available data...

10.1161/jaha.120.018799 article EN cc-by-nc-nd Journal of the American Heart Association 2021-02-10

Low-carbohydrate diets decrease hemoglobin A1c (HbA1c) among patients with type 2 diabetes at least as much low-fat diets. However, evidence on the effects of low-carbohydrate HbA1c individuals in range prediabetes to not treated by medications is limited.To study effect a behavioral intervention promoting diet compared usual 6-month changes elevated untreated HbA1c.This randomized clinical trial parallel groups was conducted from September 2018 June 2021 an academic medical center New...

10.1001/jamanetworkopen.2022.38645 article EN cc-by-nc-nd JAMA Network Open 2022-10-26

Importance Poor prepregnancy cardiovascular health (CVH) and adverse pregnancy outcomes (APOs) are key risk factors for subsequent disease (CVD) in birthing adults. The postpartum visit offers an opportunity to promote CVH among at-risk individuals. Objective To determine prevalence, predictors, trends self-reported counseling during the visit. Design, Setting, Participants Serial, cross-sectional analysis of data from 2016-2020 Pregnancy Risk Assessment Monitoring System (PRAMS), a...

10.1001/jama.2023.11210 article EN JAMA 2023-07-25

US Latinos are growing at the fastest rate of any racial/ethnic group in United States and have highest lifetime risk diabetes. Acculturation may increase diabetes among all Latinos, but this hypothesis has not been studied a nationally representative sample. The objective study was to test that acculturation associated with an increased such sample.We conducted cross-sectional analysis including 3,165 Latino participants 2007-2010 National Health Nutrition Examination Survey. Participants...

10.5888/pcd11.140142 article EN public-domain Preventing Chronic Disease 2014-10-03

Purpose The purpose of this study was to explore how adults with prediabetes perceive their risk developing diabetes and examine preferences for evidence-based treatment options prevent diabetes. Methods A qualitative conducted in 2 large Midwest primary care practices, involving in-depth semistructured interviews 35 adult patients prediabetes. Results This ethnically diverse (77% nonwhite) sample middle-aged exhibited multiple factors. Knowledge gaps about its medical management were...

10.1177/0145721716666678 article EN The Diabetes Educator 2016-09-13

Abstract Background Given the rising prevalence of dysglycemia and disparities in heart failure (HF) burden, we determined race- sex-specific lifetime risk HF across spectrum fasting plasma glucose (FPG). Methods Individual-level data from adults without baseline was pooled 6 population-based cohorts. Modified Kaplan–Meier analysis, Cox models adjusted for competing death, Irwin’s restricted mean were used to estimate risk, hazard ratio (aHR), years lived free middle-aged (40–59 years) older...

10.1186/s12933-021-01265-y article EN cc-by Cardiovascular Diabetology 2021-03-22

reduce the substantial premature morbidity and mortality associated with diabetes.

10.1001/jamainternmed.2021.4945 article EN JAMA Internal Medicine 2021-09-07

Abstract A key issue distinguishing prominent evolutionary models of human life history is whether prolonged childhood evolved to facilitate learning in a skill- and strength-intensive foraging niche requiring high levels cooperation. Considering the diversity environments humans inhabit, children’s activities should also reflect local social ecological opportunities constraints. To better understand our species’ developmental plasticity, present paper compiled time allocation dataset for...

10.1038/s41598-022-12217-1 article EN cc-by Scientific Reports 2022-05-16

To describe changes in antidiabetic medication (ADM) use and characteristics associated with ADM after initiation of noninsulin second-line therapy.

10.37765/ajmc.2023.89466 article EN The American Journal of Managed Care 2023-12-01

A tubular bone bead dating to ~ 12,940 BP was recovered from a hearth-centered activity area at the La Prele Mammoth site in Converse County, Wyoming, USA. This is oldest known Western Hemisphere. To determine taxonomic origin of bead, we extracted collagen for zooarchaeology by mass spectrometry (ZooMS). We also used micro-CT scanning morphological analysis likely skeletal elements its production. conclude that made metapodial or proximal phalanx hare (Lepus sp.). find represents first...

10.1038/s41598-024-53390-9 article EN cc-by Scientific Reports 2024-02-05

Offering patient-centered care to prevent diabetes will require collaborative decision-making between patients with prediabetes and their health providers. From the perspective of primary providers, detection should be targeted who are most likely benefit from diagnosis treatment. Improving access lifestyle intervention programs educating providers about evidence-based treatments for how effectively discuss treatment options may improve both providers' patients' engagement in prevention.

10.2337/cd17-0049 article EN cc-by-nc-nd Clinical Diabetes 2017-11-30

Introduction The aim of the current study was to test normobaric 100% oxygen (NBO) (PiO2 = 713 mmHg) for stem cell mobilization and cytokine modulation. Although therapy 1,473–2,233 is well known mobilize cells modulate cytokine, little about NBO its place on low dose stimulation phase hormetic curve oxygen. We asked question, will cytokines. A positive outcome presents potential create refine treatment protocols, expand access, optimize patient outcomes. Methods Healthy 30–35-year-old...

10.3389/fcell.2024.1377203 article EN cc-by Frontiers in Cell and Developmental Biology 2025-02-05
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