A5101528288- Luminescence Properties of Advanced Materials
- Glass properties and applications
- Advanced Chemical Physics Studies
- Solid State Laser Technologies
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular Junctions and Nanostructures
- Conducting polymers and applications
- Microwave Dielectric Ceramics Synthesis
- Luminescence and Fluorescent Materials
- Molecular Spectroscopy and Structure
- Solar Thermal and Photovoltaic Systems
- Electron Spin Resonance Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Solar Energy Systems and Technologies
- Analytical Chemistry and Sensors
- Traditional Chinese Medicine Analysis
- Synthesis and properties of polymers
- Nanoparticle-Based Drug Delivery
- Metal-Catalyzed Oxygenation Mechanisms
- Surface Modification and Superhydrophobicity
- Porphyrin and Phthalocyanine Chemistry
Wuhan University of Technology
2020-2024
Huazhong University of Science and Technology
2023-2024
Columbia University
2020-2024
Xi'an Jiaotong University
2023-2024
Tongji University
2022
Ningbo University of Technology
2022
Wuhan University
2011-2018
Zhejiang Hospital
2018
State Council of the People's Republic of China
2017
Tianshui Normal University
2003-2015
In this study, we show that HuR destabilizes p16(INK4) mRNA. Although the knockdown of or AUF1 increased p16 expression, concomitant and had a much weaker effect. The Ago2, component RNA-induced silencing complex (RISC), stabilized diminished association 3' untranslated region (3'UTR) with vice versa. While reduced Ago2 3'UTR, no influence on binding to 3'UTR. use EGFP-p16 chimeric reporter transcripts revealed mRNA decay depended stem-loop structure present in as destabilized EGFP-derived...
Peroxidase-mimicking nanozymes offer unique advantages in terms of high stability and low cost over natural peroxidase for applications bioanalysis, biomedicine, the treatment pollution. However, design high-efficiency peroxidase-mimicking remains a great challenge. In this study, we adopted structural-design approach through hybridization cube-CeO2 Pt nanoparticles to create new nanozyme with efficiency excellent stability. Relative pure nanoparticles, as-hybridized Pt/cube-CeO2...
The RNA-binding protein, HuR, associates with the HuR mRNA, but consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study regulatory paradigm. Ectopic overexpression potently enhanced translation cytoplasmic levels endogenous did not affect mRNA levels. Inhibition CRM1 function by Lemptomycin B or knockdown greatly diminished hence blocked induction exogenous HuR. Further studies showed that interacted 3′-untranslated...
Abstract Elevated levels of RNA binding protein HuR were found in various human cancers. However, the mechanisms underlying over‐expression cancers have not been fully elucidated. Here, we show that miR‐16 acts as a novel post‐transcriptional regulator for HuR. Knockdown increased MDA‐MB‐231 cells, while pre‐miR16 reduced expression. Neither knockdown nor could alter mRNA Instead, level de novo synthesized protein. Importantly, mechanistic studies showed associated with 3′UTR HuR, and...
This review provides an in-depth understanding and introduces recent progress in the design applications of DNA nanomaterials which possess intriguing structures functions.
Abstract Backgrounds Acute myocardial infarction (AMI) has been one of the most fatal diseases among all types heart due to its rapid onset and high rates fatality. Understanding accurately how multi-omics molecular features change at early stage AMI is crucial for treatment. Currently, changes involved in DNA methylation modification gene expression multiple genes have remained unexplored. Results We used RNA-seq MeDIP-seq on tissues from mouse models series time points (Sham, 10-min, 1-h,...
Solar energy utilization in buildings is crucial for conservation and carbon reduction. Previous studies have shown the promise of heat-pipe-ring (HPR) embedded building façades as effective modules solar air-conditioning systems. However, research on their thermal characteristics building-attached collectors limited. This paper fills this gap by combining experimental data numerical simulations using self-developed Fortran programs. Regression analysis HPR integration systems (BISS)...
Multi-level electron beam irradiation enabled bifunctional gradient grafting on silicon microspheres and rapid curing of silicone rubber coatings, allowing linear control hydrophilicity hydrophobicity.
Abstract The simultaneous quantitation of multiple steroid hormones in real time is great importance medical diagnosis. In this study, a portable hormone biosensor based on duplex molecular recognition coupled with signal‐amplified substrate was successfully developed for the visualization and hormones. Aptamer‐functionalized upconversion nanoparticles (UCNPs) different emission peaks are immobilized photonic crystal (PC) as nanoprobes, leading to specific assay Coupled luminescence‐enhanced...
Mitochondrial DNA (mtDNA) damage has been hypothesized to be responsible for aging and various neurological diseases. Abnormalities in 8-oxoguanine glycosylase (OGG1) function can promote oxidative damage, especially the mitochondria. Here we report changes expression of OGG1 targeting nucleus, cytosol, mitochondria both accelerated senescence mice (SAM-P/8) normal counterpart SAM-R/1 during brain aging. Our results showed that mRNA protein levels OGG1, mitochondria, level cytochrome c...
The p66Shc adaptor protein is an important regulator of lifespan in mammals, but the mechanisms responsible are still unclear. Here, we show that expression p66Shc, p52Shc, and p46Shc regulated at post-transcriptional level by microRNA let-7a. levels let-7a correlated inversely with Shc proteins without affecting mRNA levels. We identified 'seedless' interaction elements coding region mRNA; mutation sites abolished regulation Our results further revealed repression delays senescence human...
Abstract Understanding metabolism is of great significance to decipher various physiological and pathogenic processes. While progress has been made profile gene expression, how capture organ‐, tissue‐, cell‐type‐specific metabolic (i.e., tissue atlas) in complex mammalian systems lagging behind, largely owing the lack imaging tools with high resolution throughput. Here, authors applied mid‐infrared coupled heavy water (D 2 O) labeling a scope mouse organs tissues. The premise that, as D O...
BACKGROUND Ischemia-reperfusion injury is associated with vascular dysfunction. The aim of this study was to investigate the role emodin, a Chinese herbal medicine, in hypoxia-reoxygenation cultured human aortic endothelial cells (HAECs) and its effects on expression peroxisome proliferator-activated receptor-γ (PPAR-γ) nitric oxide synthase (eNOS) signaling pathway. MATERIAL AND METHODS An vitro model used (HAECs). A colorimetric method evaluated activity (PPAR-γ). Phosphorylation PPAR-γ...