A5047196332- RNA modifications and cancer
- RNA Research and Splicing
- Congenital Diaphragmatic Hernia Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Surgical Simulation and Training
- Cancer Cells and Metastasis
- Medical Image Segmentation Techniques
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
Southern University of Science and Technology
2022-2025
Jinan University
2023-2025
The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher dynamics LUAD development. We found that T follicular helper (Tfh)-like cells, germinal center B dysfunctional CD8+ cells increase tumor initiation/invasion form tertiary lymphoid structure (TLS) inside tumor. This TLS starts with an aggregation CD4+ generation CXCL13-expressing Tfh-like followed by...
Abstract In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at expense of reduced ATP production efficiency. Elucidation mechanisms rapidly proliferating malignant cells acquire sufficient in this state inefficient from glycolysis could enable development targeted therapeutic strategies. study, we observed a significant association between elevated expression levels long non-coding RNA (lncRNA)...
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<div>Abstract<p>In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at expense of reduced ATP production efficiency. Elucidation mechanisms rapidly proliferating malignant cells acquire sufficient in this state inefficient from glycolysis could enable development metabolism-targeted therapeutic strategies. In study, we observed a significant association between elevated expression...
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Lung cancer, the leading cause of cancer-related incidence and mortality worldwide, is characterised by high invasiveness poor prognosis. Novel therapeutic targets are required, especially for patients with inoperable metastatic disease requiring systemic therapies to improve patients' welfare. Recently, studies indicated that TMEM176B a positive regulator in breast gastric cancers, it could be potential target treatment. In this study, we used single-cell sequencing, proteomics, Co-IP, vivo...
Automatic instrument segmentation from surgical videos via deep learning has drawn increasing attention recently. However, interferences such as blood or illumination induce the confusion of targets, which can be further exacerbated by lack labeled data, making accurate instruments very challenging. Previous methods rarely pay to analyzing regions. In this paper, we introduce a semi-supervised framework perform task with sparse annotated videos, where structural and pixel relations are...
Studies of prognosis-related molecular markers are an important tool to uncover the mechanism tumour metastasis. Cancer susceptibility gene testing is for genetic counselling cancer risk. However, impact lung genes (LCSGs) on metastasis and prognosis has not been well studied.The list was retrospectively analysed updated. After expression profiling functional analysis, LCSG-based signatures were identified by Cox regression LASSO analyses. For translational purposes, nomograms integrating...