A5049051407- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- T-cell and B-cell Immunology
- Colorectal Cancer Screening and Detection
- Inflammasome and immune disorders
- CAR-T cell therapy research
- Lipid metabolism and disorders
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Diabetes and associated disorders
- Esophageal and GI Pathology
- Immunotherapy and Immune Responses
- Gastroesophageal reflux and treatments
- Ion channel regulation and function
Yangzhou University
2016-2025
Osaka University
2024
Hubei Provincial Hospital of Traditional Chinese Medicine
2017-2024
Hubei University of Chinese Medicine
2024
Dalian Medical University
2023
Hubei University
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017-2019
University of Southern California
2019
Showa University
2018
People's Hospital of Yangzhong
2012
Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is flavonoid monomer with confirmed antioxidant activity. However, specific effects ISL on AP have not been determined. In this study, we aimed to investigate protective effect using two mouse models. caerulein-induced mild (MAP) model, dynamic changes oxidative injury pancreatic tissue were observed after onset. We found that administration reduced serum amylase and lipase levels...
INTRODUCTION: To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases exocrine and endocrine pancreas. METHODS: A prospective cohort study was conducted using data from UK Biobank. IPFD quantified MRI a deep learning–based framework called nnUNet. The prevalence fatty change pancreas (FP) determined sex- age-specific thresholds. Associations between pancreatic were assessed with multivariate Cox-proportional hazard model adjusted for age, sex,...
Regulatory T cell (Treg)-mediated immunosuppression represents one of the crucial tumor immune evasion mechanisms and is a main obstacle for successful immunotherapy. Hypoxia, common feature solid tumors, has been associated with potentiated immunosuppression, decreased therapeutic response, malignant progression local invasion. Unfortunately, link between hypoxia Treg-mediated tolerance in gastric cancer remains poorly understood. In our study, Tregs inducible factor-1α were found to be...
Pyroptosis is a lytic form of pro-inflammatory cell death characterised as caspase 1 dependent with canonical NLRP3 inflammasome-induced gasdermin D (GSDMD) activation. We aimed to investigate the role acinar pyroptotic in pancreatic injury and systemic inflammation AP.Pancreatic pathway activation upon toxin stimulation vitro vivo was investigated. Effects pharmacological (NLRP3 caspase-1 inhibitors), constitutive (Nlrp3-/- , Casp1-/- Gsdmd-/- ) conditional (Pdx1Cre Nlrp3Δ/Δ Pdx1Cre...
Formononetin is a kind of isoflavone compound and has been reported to possess anti-inflammatory properties. In this present study, we aimed explore the protective effects formononetin on dextran sulfate sodium- (DSS-) induced acute colitis. By intraperitoneal injection in mice, disease severity colitis was attenuated dose-dependent manner, mainly manifesting as relieved clinical symptoms colitis, mitigated colonic epithelial cell injury, upregulations tight junction proteins levels (ZO-1,...
Abstract Surgical results for intrahepatic cholangiocarcinoma (ICC) remain unsatisfactory due to the high rate of recurrence. Here, we investigated that expression and roles tripartite motif‐containing protein 44 (TRIM44) in human ICCs. Firstly, TRIM44 was analyzed several kinds cancers by referring public Oncomine database, expressions mRNA were tested ICC corresponding paratumorous tissues. Secondly, functions mechanisms cells further evaluated interference cDNA transfection. Finally,...
Bile acids are altered and associated with prognosis in patients acute pancreatitis (AP). Here, we conduct targeted metabolomic analyses to detect bile changes during the (n = 326) recovery 133) phases of AP, as well healthy controls 60). Chenodeoxycholic acid (CDCA) decreases phase, increases is pancreatic necrosis. CDCA its derivative obeticholic exhibit a protective effect against acinar cell injury vitro necrosis murine models, RNA sequencing reveals that oxidative phosphorylation...
Aspirin has a clear anti-inflammatory effect and is used as an agent for both acute long-term inflammation. Previous study indicated that aspirin alleviated pancreatitis induced by caerulein in rat. However, the role of on severe (SAP) necrosis pancreatic acinar cell are not yet clear. The aim this was to determine effects treatment SAP model combined with Lipopolysaccharide. We found reduced serum amylase lipase levels, decreased MPO activity, histopathological manifestations pancreas...
Abstract: Nanoparticles can be loaded with exogenous DNA for the potential expression of cytokines immune-stimulatory function. NKG2D identifies major histocompatibility complex class I chain-related protein in human and retinoic acid early induced transcript-1 mouse, which acts as tumor-associated antigens. Biologic agents based on interleukin 21 (IL-21) have displayed antitumor activities through lymphocyte activation. The NKG2D–IL-21 fusion theoretically tumor cells moiety activates T...
Scope Naringenin (NAR) possesses unique anti‐inflammatory, antiapoptosis effects and various bioactivities; however, its role against radiation‐induced intestinal injury (RIII) remains unclear. This study aims to investigate whether NAR has protective the underlying mechanisms. Methods results C57BL/6J mice are exposed a single dose of 13 Gy X‐ray total abdominal irradiation (TAI), then gavaged with for 7 days. treatment prolongs survival rate, protects crypts villi from damage, alleviates...
Most expression quantitative trait locus (eQTL) analyses have been conducted in heterogeneous gastric tissues, limiting understanding of cell-type-specific regulatory mechanisms. Here, we employed a pooled multiplexing strategy to profile 399,683 cells from 203 Chinese individuals using single-cell RNA sequencing (scRNA-seq). We identified 19 distinct cell types and performed eQTL analyses, uncovering 8,498 independent eQTLs, with considerable fraction (81%, 6,909/8,498) exhibiting effects....
Abstract Background The outbreak of a novel coronavirus since December 2019 in Wuhan, became an emergency major international concern. As March 5, 2020, the SARS-CoV-2 epidemic has caused 80,565 confirmed infections with 3,015 fatal cases China. is challenge for clinicians. In our clinic, we found rare case that COVID-19 patient combined ischemic stroke. Case Presentation A 79-year-old man was admitted to Hubei Provincial Hospital Chinese Traditional Medicine due right limb weakness 1 day...
Parkinson's disease (PD) is a prevalent neurodegenerative disease. Long noncoding RNA small molecule host gene 1 (SNHG1) has been reported to play critical roles in progression. The study aimed further elucidate the mechanism of SNHG1 PD pathogenesis.The levels SNHG1, miR-125b-5p and mitogen-activated protein kinase (MAPK1) were determined by quantitative real-time polymerase chain reaction (qRT-PCR) or Western blot. Cell viability apoptosis evaluated Counting Kit-8 (CCK-8) assay flow...
Abstract Interleukin 2 (IL2) is a typical Th1 cytokine, and interleukin 4 (IL4) an inducible Th2 cytokine. These cytokines are critical mediators of the Th1/Th2 balance apoptosis potential involved in process inflammation‐mediated carcinogenesis human organs, including gastrointestinal tract. Therefore, we tested hypothesis that functional variants IL2 IL4 were associated with risk gastric cancer by genotyping two promoter polymorphisms G‐330T (rs2069762) T‐168C (rs2070874) case‐control...