A5100779960- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- EEG and Brain-Computer Interfaces
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Inflammation biomarkers and pathways
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- Pediatric Hepatobiliary Diseases and Treatments
- Shoulder Injury and Treatment
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Pharmacological Effects of Medicinal Plants
- Nerve injury and regeneration
- Microbial Community Ecology and Physiology
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
Children's Hospital of Fudan University
2023-2025
Traditional Chinese Medicine Hospital of Kunshan
2017-2024
Shanghai University of Traditional Chinese Medicine
2017-2024
Yangzhou University
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Shenzhen Children's Hospital
2024
Yanshan University
2022-2024
Nanjing University of Chinese Medicine
2019-2023
Mianyang Central Hospital
2023
University of Electronic Science and Technology of China
2023
INTRODUCTION: To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases exocrine and endocrine pancreas. METHODS: A prospective cohort study was conducted using data from UK Biobank. IPFD quantified MRI a deep learning–based framework called nnUNet. The prevalence fatty change pancreas (FP) determined sex- age-specific thresholds. Associations between pancreatic were assessed with multivariate Cox-proportional hazard model adjusted for age, sex,...
Abstract Objective Inflammatory bowel disease (IBD) is a disorder intestinal inflammation and impaired barrier function, associated with increased epithelial expression of monocarboxylate transporter 4 (MCT4). However, the specific non‐metabolic function clinical relevance MCT4 in IBD remain to be fully elucidated. Methods Lentivirus‐mediated overexpression was used assess role transcriptionally regulating ZO‐1 IL‐6 by luciferase assays, WB ChIP. IP analyse effect on interaction NF‐κB‐CBP or...
Degradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor synthesis glycosaminoglycans, plays biological role in remodeling improves barrier dysfunction sepsis.The number children with septic shock that were admitted to PICU at Children's Hospital Fudan University who enrolled study was 28. On days one three after enrollment, venous blood samples collected, heparan sulfate,...
Bile acids are altered and associated with prognosis in patients acute pancreatitis (AP). Here, we conduct targeted metabolomic analyses to detect bile changes during the (n = 326) recovery 133) phases of AP, as well healthy controls 60). Chenodeoxycholic acid (CDCA) decreases phase, increases is pancreatic necrosis. CDCA its derivative obeticholic exhibit a protective effect against acinar cell injury vitro necrosis murine models, RNA sequencing reveals that oxidative phosphorylation...
Glucose transporter 1 (GLUT1) facilitates the cellular uptake of glucose and is overexpressed in most cancers. The altered expression GLUT1 may influence sensitivity tumor cells to chemotherapy. This study investigated whether knockdown sensitize head neck cancer chemotherapy drug cisplatin vitro. Anti-GLUT1 antibody was used block activity protein, GLUT1-shRNA knock down its mRNA Cal27 cells. Immunocytochemistry, Western blot, qRT-PCR were detect respectively. Lentivirus carrying for MTT...
Actinomycete strain MCCC 1A01550(T), isolated from the national mangrove reserve in Fujian Province, China, was determined to belong genus Streptomyces based on a polyphasic approach. The cell wall of novel contained ll-diaminopimelic acid and galactose. predominant menaquinones were MK-9(H(4)) MK-9(H(6)) major fatty acids iso-C(16 : 0), cis9-C(16 1) C(16 0). diagnostic phospholipid phosphatidylethanolamine. DNA G+C content 71.6 mol%. Phylogenetic analysis 16S rRNA gene sequences confirmed...
Increasing incidence and mortality rates of pancreatic cancer (PC) highlight an urgent need for novel efficient drugs. Retention in endoplasmic reticulum 1 (RER1) is important retention factor the (ER). However, it remains elusive whether RER1 involved disease-related proteins. We analyzed expression level PC adjacent tissues, also employed Kaplan–Meier's analysis to identify correlation between overall survival rate. Cell proliferation, colony formation, tumor scratch test, transwell...
Abstract Background Pediatric septic shock is a critical condition associated with high mortality rates, largely due to sepsis-induced immunosuppression. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been explored as therapeutic intervention counteract this Despite its potential, the efficacy of GM-CSF in pediatric not clearly established. This study aims investigate impact administration on survival rates and identify key predictors treatment outcomes patients. Methods We...
<title>Abstract</title> Introduction The plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes adults sepsis, comprehensive investigations into lipidomic alterations pediatric sepsis are limited. This study aimed to characterize the using a metabolomics-based exploratory approach, providing insights pathophysiological mechanisms potential biomarkers. Methods A...
A Gram-negative, rod-shaped, non-motile and pink-pigmented bacterium, designated strain ZLB-3T, was isolated from a desert soil sample collected Xinjiang Province, China, characterized by using polyphasic taxonomic approach. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the isolate belongs to phylum Bacteroidetes is related genus Hymenobacter. sequence similarities between ZLB-3T type strains of Hymenobacter species with validly published names ranged 90.0 94.6 %. No...
NLRP3 inflammasome has emerged as a crucial regulator of inflammatory bowel disease (IBD) characterized by chronic the gastrointestinal tract. The expression MCT4 is significantly increased in intestinal mucosal tissue IBD, which been identified to regulate barrier function. However, function cell pyroptosis remained unknown. In this study, we have established stable line with overexpression HT-29 and CaCO2 cells, respectively. Functional analysis revealed that ectopic cells contributed...
Background Notch signaling is critical for regulating the function of vascular endothelial cells (ECs). However, effect intracellular domain Notch1 (NICD) on EC injury in sepsis remains unclear. Methods We established a cell model dysfunction and induced mouse via lipopolysaccharide (LPS) injection cecal ligation puncture (CLP). Endothelial barrier expression endothelial-related proteins were determined using CCK-8, permeability, flow cytometry, immunoblot, immunoprecipitation assays. The...
Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute to the development of persistent inflammation-immunosuppression-catabolism syndrome.However, underlying mechanism remains unclear.Exploring mechanisms MDSCs generation may provide therapeutic targets for improving immune status in sepsis.Here, a mouse model is established by cecal ligation perforation.Bone marrow at different time points are harvested detect proportion search differentially expressed genes...
HMGCS2 is the rate-limiting enzyme of ketogenesis, which vital for tumor initiation or metastasis. The aim this study to determine relationship between and angiogenesis.The consisted 100 cases with colorectal cancer healthy control, expression microvessel density (MVD) (marker: CD31) were analyzed by immunohistochemistry tube formation, centration β-hydroxybutyrate in serum was assessed biochemical analysis.The results showed that significantly reduced compared inversely correlated MVD IHC...
A novel golden-yellow-coloured strain, designated RHYL-37T, was isolated from a soil sample forest of Euphrates poplar (Populus euphratica) in Xinjiang, China. The cells were strictly aerobic, Gram-staining-negative, heterotrophic, non-spore-forming rods that motile by gliding. Growth occurred at 17–37 °C (optimum, 30 °C), pH 5.0–9.0 7.0) and with 0–1 % NaCl (w/v; optimum, 0 %). Phylogenetic analysis based on 16S rRNA gene sequences indicated the isolate formed cluster members genera...
Abstract The protein kinase D family of serine/threonine kinases, particularly PKD1, has been implicated in the regulation a complex array fundamental biological processes. However, its function and mechanism underlying PKD1-mediated bone development osteoblast differentiation are not fully understood. Here we demonstrate that loss PKD1 led to impaired through STAT3 p38 MAPK signaling using vitro vivo bone-specific conditional PKD1-knockout (PKD1-KO) mice models. These developed markedly...
Strain 10-1-101T, isolated from a sand sample collected the desert of Xinjiang, China, was Gram-negative, aerobic, motile, rod-shaped bacterium. Colonies grown on 0.1× trypticase soy broth agar were circular, convex and light-pink-coloured. The major cellular fatty acids novel strain C18 : 1 ω7c (72.71 %) C16 0 (7.05 %). DNA G+C content 10-1-101T 68.8 mol% Q-10 respiratory quinone. 16S rRNA gene sequence analysis indicated that related to type strains genus Skermanella, with similarity...
Previous studies have demonstrated the importance of TSLP-TSLPR in inflammatory, allergic, and fibrotic diseases. However, their exact molecular mechanism regulating renal fibrosis has not been fully explored yet. The current study identified high expression levels TSLP TSLPR human mouse hydronephrotic tissues. In addition, immunofluorescence staining showed that was highly expressed tubular cells, while mainly co-localized with α-SMA, a marker fibroblasts. Knocking out UUO model could...