A5074660144- Sepsis Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Immune Response and Inflammation
- Neonatal and Maternal Infections
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Immune cells in cancer
- Dialysis and Renal Disease Management
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Respiratory Support and Mechanisms
- Virus-based gene therapy research
- Galectins and Cancer Biology
- Mechanical Circulatory Support Devices
- Tuberculosis Research and Epidemiology
- Acute Kidney Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Pneumocystis jirovecii pneumonia detection and treatment
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Respiratory viral infections research
- Mycobacterium research and diagnosis
Children's Hospital of Fudan University
2018-2025
Fudan University
2023
Degradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor synthesis glycosaminoglycans, plays biological role in remodeling improves barrier dysfunction sepsis.The number children with septic shock that were admitted to PICU at Children's Hospital Fudan University who enrolled study was 28. On days one three after enrollment, venous blood samples collected, heparan sulfate,...
Abstract Background Pediatric septic shock is a critical condition associated with high mortality rates, largely due to sepsis-induced immunosuppression. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been explored as therapeutic intervention counteract this Despite its potential, the efficacy of GM-CSF in pediatric not clearly established. This study aims investigate impact administration on survival rates and identify key predictors treatment outcomes patients. Methods We...
Background Notch signaling is critical for regulating the function of vascular endothelial cells (ECs). However, effect intracellular domain Notch1 (NICD) on EC injury in sepsis remains unclear. Methods We established a cell model dysfunction and induced mouse via lipopolysaccharide (LPS) injection cecal ligation puncture (CLP). Endothelial barrier expression endothelial-related proteins were determined using CCK-8, permeability, flow cytometry, immunoblot, immunoprecipitation assays. The...
Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute to the development of persistent inflammation-immunosuppression-catabolism syndrome.However, underlying mechanism remains unclear.Exploring mechanisms MDSCs generation may provide therapeutic targets for improving immune status in sepsis.Here, a mouse model is established by cecal ligation perforation.Bone marrow at different time points are harvested detect proportion search differentially expressed genes...
<title>Abstract</title> <bold>Background</bold> Septic shock in pediatric patients frequently leads to high mortality rates, primarily attribute sepsis-induced immunosuppression. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a potential therapy mitigate this However, the effect of GM-CSF septic remains uncertain. This study aimed investigate administration and identify treatment outcome predictors with shock. <bold>Methods</bold> The retrospective cohort was...
Background: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute the development of persistent inflammation-immunosuppression-catabolism syndrome (PICS). However, underlying mechanism remains unclear. Exploring mechanisms MDSCs generation may provide therapeutic targets for improving immune status in late sepsis.Methods: A mouse model was established cecal...
Sepsis is a critical condition affecting patients worldwide. Systemic inflammatory response syndrome in sepsis contributes to organ dysfunction and mortality. The oXiris recently developed continuous renal replacement therapy (CRRT) hemofilter indicated for the adsorption of cytokines from bloodstream. In our study, septic child, CRRT with three filters, including hemofilter, resulted downregulation biomarkers reduction vasopressors. Herein, we described first report such usage children.
To explore whether the lipopolysaccharide (LPS)-induced modification of O-linked N-acetylglucosamine (O-GlcNAc) is involved in inflammatory signaling pathway endothelial cells.Human umbilical vein cells (HUVEC) were cultured vitro, and logarithmic growth phase used for experiments. Cells divided into blank control group, LPS group (2 000 mg/L LPS), O-GlcNAc transferase (OGT) overexpression (OGT-OE)+LPS (plasmid transfection OGT+2 protein kinase C (PKC) inhibitor+LPS (10 μmol/L Go 6983+2 RhoA...
Abstract Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute to the development of persistent inflammation-immunosuppression-catabolism syndrome. However, underlying mechanism remains unclear. Exploring mechanisms MDSCs generation may provide therapeutic targets for improving immune status in sepsis. Here, a mouse model is established by cecal ligation perforation. Bone marrow at different time points are harvested detect proportion search differentially expressed...
The mortality of sepsis remains high, and it is still a major cause death in critically ill patients.But its pathophysiological mechanism mystery, not yet fully clear.Endothelium play an important role the development sepsis.Maintaining integrity surface glycocalyx to certain extent reduces damage; destruction mediates series responses, including increasing vascular permeability by cell pathway or intracellular pathways, adhesion white blood cells endothelial variety cytokines promote...
Adenovirus pneumonia is a common type of in immunocompetent and immunocompromised patients, its prognosis poor.Antiviral therapy includs ganciclovir, valganciclovir, cidofovir, brincidofovir, ribavirin so on.Among them, cidofovir brincidofovir have obvious antiviral activity against adenovirus vitro vivo, but further RCT results are still needed.Therefore, needs study. Key words: Adenovirus; Ganciclovir; Cidofovir; Ribavirin
Aims & Objectives: To evaluate the efficiency of newly published pSOFA score to predict risk death in critically ill children with sepsis. Methods: Eight PICU were enrolled from Jiangsu, Zhejiang and Shanghai between August 2016 July 2017. The data collected included age, gender, length stay, for all subjects. Death hospital was mainly clinical outcome. performance assessed by area under ROC curve. calibration predicting mortality evaluated Hosmer-Lemeshow goodness fit test. Results: A total...
Abstract Objective: To summarize the clinical features, laboratory parameters, and outcomes of children with acute hypoxemic respiratory failure supported by extracorporeal membrane oxygenation explore risk factors prognosis. Methods: It’s a retrospective study from one hospital Pediatric Intensive Care Unit Children’s Hospital Fudan University in China. Patients, aged 28 days to 18 years, mechanical ventilation underwent January 2015 December 2019 were enrolled this study. The primary...