A5100779967- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Respiratory Support and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Nitrogen and Sulfur Effects on Brassica
- Mycobacterium research and diagnosis
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- Acute Kidney Injury Research
Fujian Provincial Hospital
2017-2023
Fujian Medical University
2017-2023
Fujian Provincial People's Hospital
2021-2023
Fudan University
2023
Suzhou Municipal Hospital
2017
Nanjing Medical University
2017
Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative of more than 90% protein-coding genes, providing an essential source for biological versatility. This study finds that SRSF3 expression is associated with drug resistance and poor prognosis in pancreatic cancer. We also find ANRIL m6A modification cancer cells. More importantly, we demonstrate methylation on lncRNA the splicing. Moreover, our results show promotes gemcitabine by regulating ANRIL's ANRIL-208 (one...
Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while relationship between these two RNA modifications remains unclear.RNA sequencing (RNA-seq) was performed using 15 pairs ductal adenocarcinoma (PDAC) tissues corresponding normal tissues, Cdc2-like kinases 1 (CLK1) identified as a significantly upregulated related gene. Real-time quantitative PCR (qPCR) western blotting were applied to determine CLK1 levels. The...
Hydrofluoric acid (HF) is a highly corrosive agent and can cause burns. HF penetrate deeply into tissues through intact skin the lipid barrier, leading to painful liquefactive necrosis, inducing hypocalcemia hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability cases of poisoning.A 25-year-old man fell an electroplating pool containing 10% 50% nitric acid.He had severe cutaneous injuries...
Hepatocellular carcinoma (HCC) is characterized by uncontrolled proliferation and the deregulation of apoptotic signaling, although its molecular pathogenesis not fully characterized. The ability to inhibit excessive induce apoptosis cancer cells are crucial characteristics anticancer drugs. Pien Tze Huang (PZH) a widely used traditional Chinese medicine for treatment various types cancer, has exhibited promising therapeutic effects in clinical trials HCC. However, underlying mechanisms...
Background: This study aimed to determine whether salvage hepatectomy offers prognostic advantages for unresectable hepatocellular carcinoma (uHCC) patients with clinical complete response (cCR) after conversion therapy.Methods: A total of 74 consecutive uHCC cCR therapy at seven major cancer centers in China between October 2018 and December 2021 were included.One-to-one propensity score matching (PSM) was performed minimize the influence potential confounders.Disease-free survival (DFS)...
Anti-silencing function protein 1 homolog B (ASF1B) has been implicated in the occurrence and development of cancers. The present work explored functional role expression regulation ASF1B pancreatic ductal adenocarcinoma (PDAC). Based on real-time quantitative PCR (qRT-PCR) immunohistochemistry (IHC), was significantly upregulated PDAC tissues. High associated with a poor overall survival (OS) recurrence-free (DFS) patients. also showed relatively higher cells (AsPC-1, PANC-1) when compared...
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide; however, accurate prognostic tools are still lacking. We aimed to identify immunohistochemistry (IHC)-based signature as a classifier predict recurrence and survival in patients with HCC at Barcelona Clinic Liver Cancer (BCLC) early- immediate-stage. In total, 567 who underwent curative liver resection two independent centers were enrolled. The least absolute shrinkage selection operator regression model was used...
Background: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute the development of persistent inflammation-immunosuppression-catabolism syndrome (PICS). However, underlying mechanism remains unclear. Exploring mechanisms MDSCs generation may provide therapeutic targets for improving immune status in late sepsis.Methods: A mouse model was established cecal...
Purpose: Postoperative prognosis prediction models for patients with stage Ⅰ and Ⅱ hepatocellular carcinoma (HCC) according to the 8th edition of Tumor-Node-Metastasis staging system after surgery are rare. This study aimed build a prognostic score predict survival outcomes stratify these into different strata. Patients Methods: We developed web-based nomogram that incorporated four selected risk factors based on multivariate Cox regression, using training set (n=3567) from Surveillance,...
Familial adenomatous polyposis is characte-rized by the multiple and polyps in colorectum combined with stomach duodenum, while it rarely seen common bile duct (CBD). In July 2013, 1 patient FAP adenomas CBD was admitted to Fujian Provincial Hospital. The underwent laparoscopic exploration resection of masses due acute pancreatitis 11 months ago, confirmed as adenoma distal postoperative pathological examination. Multiple were found stomach, CBD, after admission hospital, biopsy that tubular...
Abstract Introduction Clinicians increasingly perform laparoscopic surgery for intrahepatic cholangiocarcinoma (ICC). However, this can be difficult in patients with advanced-stage ICC because of the complicated procedures and difficulty achieving high-quality results. We compared effects a three-step optimized procedure traditional ICC. Methods Forty-two who received hemihepatectomy lymph node dissection (LND, group) 84 propensity score-matched plus LND (traditional were analyzed. Surgical...