A5087350082- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Circular RNAs in diseases
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- RNA Research and Splicing
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Neonatal and fetal brain pathology
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience of respiration and sleep
- Renal and related cancers
- Diagnosis and Treatment of Venous Diseases
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
Wenzhou Medical University
2021-2025
First Affiliated Hospital of Wenzhou Medical University
2021-2025
Nanjing Medical University
2012-2025
Nanjing Traditional Chinese Medicine Hospital
2025
Xi'an Chest Hospital
2024-2025
Anhui Medical University
2013-2024
Xian Yang Central Hospital
2024
Henan Provincial Center for Disease Control and Prevention
2013-2024
Jiangsu Province Hospital
2015-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number non-coding RNA-containing exosomes that facilitate development and metastasis. However, precise mechanisms cell-derived during hypoxia are unknown. Here, we aim to clarify whether affects growth progression by transferring long RNA-urothelial cancer-associated 1 (lncRNA-UCA1) enriched secreted from bladder cancer cells. We used 5637 with high expression lncRNA-UCA1 as exosome-generating UMUC2...
Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative of more than 90% protein-coding genes, providing an essential source for biological versatility. This study finds that SRSF3 expression is associated with drug resistance and poor prognosis in pancreatic cancer. We also find ANRIL m6A modification cancer cells. More importantly, we demonstrate methylation on lncRNA the splicing. Moreover, our results show promotes gemcitabine by regulating ANRIL's ANRIL-208 (one...
Numerous studies suggest that several long non-coding RNAs (lncRNAs) play critical roles in bladder cancer development and progression. Long RNA urothelial cancer-associated 1 (lncRNA-UCA1) is highly expressed tissues cells, it has been shown to an important role regulating aggressive phenotypes of cells. However, little known about the molecular mechanism lncRNA-UCA1-mediated cell migration invasion. Here, we show overexpression lncRNA-UCA1 could induce EMT increase migratory invasive...
Long non-coding ribonucleic acid urothelial carcinoma-associated 1 has been found to be a participant in cancer development and glucose metabolism bladder cancer. However, the role of metabolic reprogramming remains clarified. In this study, we aim elucidate molecular mechanism underlying regulation glutamine by The RNA levels 1, GLS2 miR-16 tissues cell lines were examined real-time reverse transcriptase-polymerase chain reaction. protein detected western blot analysis. Reactive oxygen...
This study aims to identify whether Urothelial Cancer Associated 1 (UCA1) regulates mitochondrial metabolic reprogramming in bladder cancer, and explore how UCA1 participates metabolism by the UCA1/miR-195/ARL2 signaling pathway; these findings may be aid development of tumor diagnostic therapeutic strategies.Bladder tissues were obtained from patients. Stable cell lines constructed, with ectopic expression UMUC2 cells knockdown 5637 cells. The levels UCA1, miR-195, ARL2 detected real-time...
Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while relationship between these two RNA modifications remains unclear.RNA sequencing (RNA-seq) was performed using 15 pairs ductal adenocarcinoma (PDAC) tissues corresponding normal tissues, Cdc2-like kinases 1 (CLK1) identified as a significantly upregulated related gene. Real-time quantitative PCR (qPCR) western blotting were applied to determine CLK1 levels. The...
Gastric cancer is one of the most common malignancies globally; stem cells (CSCs) are regarded as being at root tumor progression, and there thus a need to identify potential drugs target CSCs. The long non-coding RNA MALAT1 promotes epithelial-mesenchymal transition angiogenesis in colorectal cancer, but it unknown whether affects stemness gastric cells. Here, we found that knockdown (KD) attenuated non-adherent cell spheroids, evidenced by decrease primary secondary spheroid formation...
Huang-Lian-Jie-Du decoction (HLJDD) has been widely applied to treat inflammation-associated diseases for thousands of years in China. However, the concrete molecular mechanism HLJDD treatment rheumatoid arthritis (RA) remains unclear. In this work, network pharmacology and docking were preliminarily analyze potential active ingredients, drug targets, related pathways on treating RA. A total 102 compounds with corresponding 189 targets identified from HLJDD, 41 common further by intersecting...
Escherichia coli plays a crucial role in various inflammatory diseases and infections that pose significant threats to both human health the global environment. Specifically inhibiting growth of pathogenic E. is great urgent concern. By modifying gold nanoparticles (AuNPs) with poly[2-(methacrylamido)glucopyranose] (pMAG) poly[2-(methacryloyloxy)ethyl trimethylammonium iodide] (pMETAI), novel recyclable coli-specific-killing AuNP-polymer (ESKAP) nanocomposite proposed this study, which based...
It is important to effectively maintain and modulate the bioactivity of protein-nanoparticle conjugates for their further intensive applications. The strategies controlling protein activity via "tailor-made surfaces" still have some limitations, such as difficulties in modulation proteolysis by proteases. Thus, it essential establish a responsive conjugate system realize not only controllable modulations incorporating sensitivity environmental cues but also high resistance In work reported...
Abstract Background and Aim The aim of our study was to investigate the immunomodulatory effect short‐term efficacy long‐term prognosis decompensated liver cirrhosis patients caused by hepatitis B after a double transplantation with human umbilical cord mesenchymal stem cells (hUCMSCs). Methods Fifty inpatients were recruited given same medical treatments, receiving hUCMSCs injection intravenously. Fifty‐three (Group B) matched for age, sex, baseline alanine aminotransferase, aspartate...
Abstract As the most predominant tumour‐infiltrating immune cells, tumour‐associated macrophages ( TAM s) are significant for fostering tumour growth, progression and metastasis. CD 68‐positive s display dissimilarly polarized programmes comprising 11c‐positive pro‐inflammatory (M1) 206‐positive immunosuppressive (M2). The aim of this study is to determine prognostic significance diametrically in hepatocellular carcinoma HCC ) their application risk stratification patients according specific...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by dismal prognosis. Treatment outcomes exhibit substantial variability across patients, underscoring the urgent need for robust predictive models to effectively estimate survival probabilities and therapeutic responses in PDAC. Metabolic immune-related genes exhibiting differential expression were identified using TCGA-PDAC GTEx datasets. A genetic prognostic model was developed via univariable Cox...
The coexistence of pulmonary tuberculosis (PTB) and embolism (PE) is an uncommon clinical condition, its rarity associated with a high mortality rate, underscoring the critical importance early diagnosis. purpose this study to develop validate nomogram model for predicting risk PE in patients PTB. We included 694 PTB development cohort 236 validation from another center. A prediction was established based on independent factors. nomogram's performance evaluated using area under receiver...
Ceftazidime avibactam (CAZ-AVI) is recommended for treating severe infections caused by multidrug-resistant gram-negative bacteria (MDR-GNB). However, there are few real-world studies on the use of CAZ-AVI to treat lower respiratory tract (LRTIs) MDR-GNBs in intensive care units (ICUs). This study aimed evaluate clinical characteristics patients with LRTIs MDR-GNB who were treated ICU, and investigate independent risk factors mortality. single-center retrospective included ICU a tertiary...
Endometrial cancer is one of the most common types gynecological malignancy worldwide. Novel biomarkers and therapeutic targets are imperative for improving patients' survival. Previous studies have suggested long non-coding RNA H19 as a potential biomarker. To investigate role in endometrial cancer, present study examined expression pattern tissues by quantitative polymerase chain reaction, characterized its function cell line via knocking down with small interfering RNAs. It was found that...
Abstract It is necessary to develop prognostic tools of metastatic pancreatic cancer ( MPC ) for optimizing therapeutic strategies. Thus, we tried and validate a nomogram . Data from 3 clinical trials (NCT00844649, NCT01124786, NCT00574275) 133 Chinese patients were used analysis. The former 2 taken as the training cohort while NCT00574275 was validation cohort. In addition, treated in China testing Cox regression model investigate factors With these factors, established verified it by...