A5048041484- Mast cells and histamine
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Salmonella and Campylobacter epidemiology
- Cancer-related Molecular Pathways
- Asthma and respiratory diseases
- DNA Repair Mechanisms
- Antibiotic Resistance in Bacteria
- Fibroblast Growth Factor Research
- Drug-Induced Adverse Reactions
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Acupuncture Treatment Research Studies
- Genomics, phytochemicals, and oxidative stress
- Nitrogen and Sulfur Effects on Brassica
- Eosinophilic Disorders and Syndromes
- FinTech, Crowdfunding, Digital Finance
- Bioactive Compounds and Antitumor Agents
- Circadian rhythm and melatonin
- Lipid metabolism and biosynthesis
- Kruppel-like factors research
- Glutathione Transferases and Polymorphisms
- Animal Nutrition and Physiology
- Escherichia coli research studies
Zhejiang University
2023-2024
Institute of Animal Sciences
2024
Sanya University
2023-2024
First Affiliated Hospital of Xi'an Jiaotong University
2013-2023
Xi'an Jiaotong University
2014-2023
Tiande (China)
2018
State Key Laboratory of Cotton Biology
2018
Henan University
2018
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2017
To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number non-coding RNA-containing exosomes that facilitate development and metastasis. However, precise mechanisms cell-derived during hypoxia are unknown. Here, we aim to clarify whether affects growth progression by transferring long RNA-urothelial cancer-associated 1 (lncRNA-UCA1) enriched secreted from bladder cancer cells. We used 5637 with high expression lncRNA-UCA1 as exosome-generating UMUC2...
Abstract DNA replication is a central procedure of cell proliferation, whereas aberrant indicated to be driving force oncogenesis. Minichromosome maintenance complex component 7 (MCM7) plays an essential role in initiating replication. To investigate the potential oncogenic properties and prognostic value MCM7 hepatocellular carcinoma (HCC), we conducted immunohistochemistry staining 153 HCC samples found that high expression level was associated with worse overall survival (OS) patients....
Antimicrobial resistance (AMR) has become a significant global challenge, with an estimated 10 million deaths annually by 2050. The emergence of AMR is mainly attributed to mobile genetic elements (MGEs or mobilomes), which accelerate wide dissemination among pathogens. interaction between mobilomes and genes (or resistomes) in Salmonella, primary cause diarrheal diseases that results over 90 cases annually, remains poorly understood. available fragmented incomplete genomes remain limitation...
Eggs, an important part of a healthy daily diet, can protect chicken embryo development due to the shell barrier and various antibacterial components within egg white. Our previous study demonstrated that
Melatonin is an important bioactive molecule in plants. Two synthetases, N-acetylserotonin methyltransferase (ASMT) and serotonin N-acetyltransferase (SNAT) are involved the final two steps of melatonin synthesis. participates responses to a variety biotic abiotic stresses plants, but few studies have addressed roles endogenous pathogen resistance. We investigated role resistance Botrytis cinerea infection Arabidopsis thaliana model system. Plant lines that overexpressed ASMT or SNAT through...
Immunologic contact urticaria (ICU) is characterized by the wheal and flare reaction from direct with a chemical or protein agent, which involves type I hypersensitivity mediated allergen-specific immunoglobulin E (sIgE). Myricetin (Myr), bioactive flavonoid, exhibits antiinflammatory activities. Our results showed that treatment Myr could alleviate ICU symptoms, including decrease in number of wheals scratching, inhibit ear swelling IgE/DNFB-induced mice. The serum level IgE, histamine,...
Salmonella, a common zoonotic pathogen, is significant concern for public health, particularly when it contaminates animal-borne products. The potential Salmonella to infect duck embryos and disrupt their normal development not only causes substantial economic losses the industry but also poses severe threat health. However, there lack of understanding about prevalence in health implications. Our study aims fill this gap by providing genomic features antimicrobial resistance virulence...
Abstract Coinfection, the simultaneous invasion of multiple pathogens into a single host, is critical but understudied area, especially in farm animal sector. We report unique and unusual fatal case coinfection with S . Indiana Kentucky, which has rarely been studied literature could hold potential importance for veterinary clinics. In silico analysis revealed that all isolates exhibited extensive multidrug resistance. By analyzing plasmids, two replicons, IncHI2 IncHI2A, were detected...
Chronic urticaria (CU) is a skin allergy caused by the excessive activation of mast cells. The main etiology CU type I allergic reaction mediated immunoglobulin (Ig)E. This study mainly explored therapeutic effect quercetin in ovalbumin (OVA)-induced mice and investigated its target mechanism vitro. symptom-alleviating was assessed model. possible molecular mechanisms were initially inferred through bioinformatic multi-database analyses. Quercetin targets examined using cell experiments with...
Mast cells play an essential role in IgE-FcεR1-mediated allergic diseases. Citrus aurantium is a prolific source of flavonoids with various biological activities, including anti-inflammatory, antioxidant, and anti-tumor efficacies. Neohesperidin novel flavonoid isolated from the leaves C. aurantium. In this study, anti-allergic anti-inflammatory potentials neohesperidin were investigated along its molecular mechanism. The anti-anaphylactic activity was evaluated through hind paw...
Abstract Objectives To investigate the inhibitory effects of Kaempferol, a natural flavonol active compound, on pseudo-allergic reactions (in vivo and in vitro), particularly mechanism underlying its effect human mast cells. Methods Compound 48/80 (C48/80)-induced immunoglobulin E (IgE)-independent passive cutaneous anaphylaxis (PCA) model systemic were applied to anti-allergic activity Kaempferol. The degranulation assay, calcium imaging secretion cytokines chemokines used evaluate cell...
Tyrosine 367 Cysteine-fibroblast growth factor receptor 4 cell membrane chromatography combined with high-performance liquid and mass spectrometry was developed. Cysteine-HEK293 cells were used as the stationary phase. The specificity reproducibility of evaluated using 1-tert-butyl-3-{2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl}urea, nimodipine dexamethasone acetate. Then, anti-tumor components acting on screened identified from extracts Ligusticum...