A5015963111- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Streptococcal Infections and Treatments
- Microbial infections and disease research
- Probiotics and Fermented Foods
- Enterobacteriaceae and Cronobacter Research
- Legionella and Acanthamoeba research
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Listeria monocytogenes in Food Safety
- Antimicrobial Resistance in Staphylococcus
- Food Safety and Hygiene
- Infective Endocarditis Diagnosis and Management
- Plant Pathogenic Bacteria Studies
- Genetically Modified Organisms Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Zoonotic diseases and public health
- Forensic Entomology and Diptera Studies
- Bacillus and Francisella bacterial research
Zhejiang University
2022-2024
University of Chinese Academy of Sciences
2024
State Key Laboratory of Agricultural Microbiology
2022
Huazhong Agricultural University
2017-2022
University of Florida
2016-2021
Chinese Academy of Fishery Sciences
2017
Abstract Infectious disease outbreaks transcend the medical and public health realms, triggering widespread panic impeding socio-economic development. Considering that self-limiting diarrhoea of sporadic cases is usually underreported, Salmonella outbreak (SO) study offers a unique opportunity for source tracing, spatiotemporal correlation, prediction. To summarize pattern SO estimate observational epidemiological indicators, 1,134 qualitative reports screened from 1949 to 2023 were included...
Invasive nontyphoidal
Multiple synergistic factors affect the development and composition of mammalian gut microbiota, but effects host genetics remain unclear. To illuminate role on we employed animals with a graduated spectrum genetic variation minimal environmental influences. We bred 228 calves linearly varying breed from 100% Angus (Bos taurus) to Brahman indicus), as proxy for variation, then raised offspring in same environment identical diets. hypothesized each would harbor distinct microbiota due...
Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with ~15% case fatality in many countries. However, the mechanism by which iNTS emerged China remains unaddressed. We conducted clinical investigations of infection recurrent treatment failure, caused underreported enterica serovar Livingstone (SL). Genomic epidemiology demonstrated five clades SL population and suggested that international animal feed trade was a likely vehicle for their introduction into China, as...
Understanding changes in pathogen behavior (e.g. increased virulence, a shift transmission channel) is critical for the public health management of emerging infectious diseases. Genome degradation via gene depletion or inactivation recognized as pathoadaptive feature evolving with host. However, little known about exact role genome affecting pathogenic behavior, and underlying molecular detail has yet to be examined. Using large-scale global avian-restricted Salmonella genomes spanning more...
Antimicrobial resistance (AMR) has become a significant global challenge, with an estimated 10 million deaths annually by 2050. The emergence of AMR is mainly attributed to mobile genetic elements (MGEs or mobilomes), which accelerate wide dissemination among pathogens. interaction between mobilomes and genes (or resistomes) in Salmonella, primary cause diarrheal diseases that results over 90 cases annually, remains poorly understood. available fragmented incomplete genomes remain limitation...
The global spread of plasmid-borne carbapenem resistance is an ongoing public health challenge; however, the nature such horizontal gene transfer events among complex bacterial communities remains poorly understood. We examined in-situ globally dominant New Delhi metallo-β-lactamase (NDM)-5-positive IncX3 plasmid (denoted pX3_NDM-5) in hospital wastewater to simulate a real-world, One Health antimicrobial context.
Typhoid fever is a life-threatening disease caused by Salmonella enterica serovar Typhi, resulting in significant burden across developing countries. Historically, China was very much close to the global epicenter of typhoid, but role typhoid transmission within and among remains overlooked previous investigations. By using newly produced genomics on national scale, we clarify complex local history such notorious agent spanning most recent five decades, which largely undermines public health network.
Salmonella is a group of bacteria that constitutes the leading cause diarrheal diseases, posing great disease burden worldwide. There are numerous pathways for zoonotic transmission to humans; however, role companion animals in spreading these largely underestimated China. We aimed investigate prevalence pet dogs and cats Hangzhou, China, characterize antimicrobial resistance profile genetic features pet-derived pathogens. In total, 137 fecal samples pets were collected from an animal...
Typhoid fever is a life-threatening disease caused by Salmonella enterica serovar Typhi (S. Typhi) and remains significant public health burden in developing countries. In China, typhoid endemic with limited number of reported outbreaks. Recently, Chinese local Center for Disease Prevention Control starting to apply whole genome sequencing tracking the source outbreak isolates. this study, we conducted retrospective investigation into community Lanling, 2016. A total 26 S. isolates were...
The emergence of infections caused by antimicrobial resistant microorganisms (ARMs) is currently one the most important challenges to public health and medicine. Though speculated originate at least partially from overuse antibiotics during food animal production, we hypothesized that cattle are exposed ARMs in environment. In this cohort study, a herd beef calves with no previous exposure was followed first year life order investigate rate colonization bacteria third-generation...
Although the over-use of antibiotics during food animal production is a potential driver antimicrobial resistant microorganisms (ARMs), high prevalence cefotaxime bacteria (CRB) has been observed in grazing animals raised without antibiotic supplementation. In this cross-sectional study, and concentration CRB beef cattle on farms were investigated. Fecal samples from recto-anal junction (n = 840) environmental 258) collected 17 North Central Florida United States, survey farm...
MDR Escherichia coli are considered a global threat because of the decreasing options for antimicrobial therapy. Companion animals could be reservoir E. , and numbers pets households owning in China booming.
Pseudorabies virus (PRV) causes high mortality and miscarriage rates in the infected swine, eradication policy coupled with large-scale vaccination of live attenuated vaccines has been adopted globally against PRV. Differential diagnosis vaccinated swine is highly demanded. Our multienzyme isothermal rapid amplification (MIRA)-Cas12a detection method described this study can diagnose PRV a superior sensitivity comparable to quantitative PCR (qPCR) competitive speed (only half time as qPCR...
Macroalgae contribute approximately 15% of the primary productivity in coastal marine ecosystems, fix up to 27.4 Tg carbon per year, and provide important structural components for life waters. Despite this ecological commercial importance, direct measurements comparisons short-term responses elevated pCO2 seaweeds with different life-history strategies are scarce. Here, we cultured several seaweed species (bloom forming/nonbloom forming/perennial/annual) laboratory, tanks an indoor mesocosm...
Multidrug-resistant (MDR) Escherichia coli isolates pose global threats to public health due the decreasing availability of treatment options. To better understand characteristics MDR E. isolated from food-producing animals with no antibiotic exposure, we employed genomic comparison, high-resolution phylogenetics, and functional characterization. Our findings highlight potential capacity cause severe disease suggest that these strains are widespread intercontinentally. This study underlines...
Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 is an enteric pathogen that causes life-threatening disease in humans, with cattle being major natural reservoirs. A group of STEC a dramatic combination high virulence potentials and super-shedder bovine origin have been isolated. Here, isolate, JEONG-1266, was analyzed by comparative genomics, stx genotyping, phenotypic analyses. The phylogenetic typing whole-genome comparison consistently showed JEONG-1266 genetically close to...
ABSTRACT Streptococcus suis , a zoonotic bacterium found primarily in pigs, has been recognized recently as an emerging pathogen of humans. Herein, we describe the genome strain SC19, hypervirulent and vaccine candidate isolated from pig amid 2005 outbreak China.
NDM-producing Enterobacteriaceae are a major clinical concern worldwide. We characterized NDM-positive pathogens isolated from patients and assessed the dissemination patterns of blaNDM genes in hospital setting.Eleven (three Enterobacter hormaechei, six Klebsiella pneumoniae two Escherichia coli) were nine over 1 year period. Antimicrobial susceptibility was by MICs. A combination short- long-read WGS used for genome analysis. Clinical treatment history linked with genetic features...