A5101906866- Zebrafish Biomedical Research Applications
- Epigenetics and DNA Methylation
- Influenza Virus Research Studies
- Salmonella and Campylobacter epidemiology
- Immune cells in cancer
- Polysaccharides and Plant Cell Walls
- Single-cell and spatial transcriptomics
- Hydrogels: synthesis, properties, applications
- CRISPR and Genetic Engineering
- Corneal surgery and disorders
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Polysaccharides Composition and Applications
- Safe Handling of Antineoplastic Drugs
- Air Quality and Health Impacts
- Tuberous Sclerosis Complex Research
- Noise Effects and Management
- Microbial Inactivation Methods
- Ammonia Synthesis and Nitrogen Reduction
- Escherichia coli research studies
- Protein Degradation and Inhibitors
Zhejiang University
2019-2025
Sanya University
2023-2025
Zhejiang University-University of Edinburgh Institute
2024-2025
Zhejiang Mariculture Research Institute
2025
University of Pennsylvania
2011-2024
Chengdu University of Traditional Chinese Medicine
2024
Ministry of Agriculture and Rural Affairs
2022-2023
Shanghai Children's Hospital
2023
Shanghai Jiao Tong University
2022-2023
UNSW Sydney
2023
Despite ongoing efforts to improve the quality of pediatric resuscitation, it remains unknown whether survival in children with in-hospital cardiac arrest has improved.Between 2000 and 2009, we identified (<18 years age) an at hospitals >3 participation >5 cases annually within national Get With The Guidelines-Resuscitation registry. Multivariable logistic regression was used examine temporal trends discharge. We also explored were attributable improvement acute resuscitation or...
Protein arginine methyltransferase 5 (PRMT5) has been implicated as a key modulator of lymphomagenesis. Whether PRMT5 overt oncogenic function in the context leukemia/lymphoma and whether it represents therapeutic target remains to be established. We demonstrate that inactivation inhibits colony-forming activity by multiple drivers, including cyclin D1, c-MYC, NOTCH1, MLL-AF9. Furthermore, we overexpression specifically cooperates with D1 drive lymphomagenesis mouse model, revealing inherent...
Coriander (Coriandrum sativum) is a classical medicinal and edible herb as well spice, but the physicochemical biological properties of its polysaccharides have not been fully studied. In this study, were extracted using an ultrasonic-assisted method purified from fresh coriander, then coriander polysaccharide (CSP) fraction was separated agarose gel Q-Sepharose Fast Flow column. The total sugar content, protein content monosaccharides composition CSPs determined phenol–sulfuric acid method,...
Nitric oxide (NO) is known to play a critical role in enhancing wound healing as topical NO administration has demonstrated enhanced diabetic animal models. However, this approach been limited by the short duration of release, half-life NO, and instability available donors. To overcome these deficiencies, we have developed new delivery platform based on grafting S-nitrosothiols (RSNOs), derived from endogenous glutathione (GSH) or its oligomeric derivatives, phytochelatins (PCs), onto...
This study aimed to investigate the factors that affect continuance intention use technology among English teachers in China, mainly by examining direct effects of help seeking, interest, effort regulation, growth mindset, facilitating conditions, perceived usefulness, and ease on (CI), indirect above have through self-efficacy. The sample comprised 459 language from junior secondary schools different regions Western China. A questionnaire involved variables was used, it validated using...
B cells infiltrate pancreatic ductal adenocarcinoma (PDAC) and in preclinical cancer models, can suppress T cell immunosurveillance cancer. Here, we conducted a pilot study to assess the safety feasibility of administering lentiviral-transduced chimeric antigen receptor (CAR)-modified autologous redirected against mesothelin target tumor along with CART CD19 deplete cells. Both CARs contained 4-1BB CD3ζ signaling domains. Three patients chemotherapy-refractory PDAC received 1.5 g/m2...
Non-alcoholic fatty liver disease (NAFLD) is a chronic and metabolic commonly occurs in humans with obesity type 2 diabetes mellitus (T2DM); such condition also exists animals as rodents laying hens. Since the pathogenesis of hemorrhagic syndrome (FLHS) hens similar to human NAFLD, hen's FLHS selected study model NAFLD. Altered circulating amino acids, particularly elevated branched-chain acids (BCAAs) aromatic (AAAs), are consistently reported patients NAFLD T2DM. How long-term dietary...
Abstract Background Influenza A viruses (IAVs) are zoonotic, segmented negative-stranded RNA viruses. The rapid mutation of IAVs results in host immune response escape and antiviral drug vaccine resistance. RUNX1 is a transcription factor that not only plays essential roles hematopoiesis, but also functions as regulator inflammation. However, its role the innate immunity to IAV infection has been well studied. Methods To investigate effects on explore mechanisms uses during infection. We...
During the aging process of laying hens, hepatic oxidative stress damage and lipid accumulation are prone to occur, leading deterioration egg quality a decline in production properties. This research was designed explore effects different levels coated sodium butyrate (CSB) addition on oxidation resistance, inflammatory reaction, metabolism damage-related gene expression aged hens. A total 720 healthy 52 weeks old Huafeng hens were arbitrarily divided into 5 groups 6 replicates with 24 birds...
Bacterial regional demonstration after global dissemination is an essential pathway for selecting distinct finesses. However, the evolution of resistome during transition to endemicity remains unaddressed. Using most comprehensive whole-genome sequencing dataset Salmonella enterica serovar Gallinarum ( S . Gallinarum) collected from 15 countries, including 45 newly recovered samples two related local regions, we established relationship among avian-specific pathogen genetic profiles and...
Salmonella , a significant threat to public safety, inflicts substantial economic losses on the poultry industry. The unique “parental feeding” breeding model of pigeon farms, against “all-in & all-out” biosecurity strategy, makes them susceptible infections and subsequent outbreaks paratyphoid. This study initially studied three paratyphoid outbreak incidents in Henan, China, which 53 strains pigeon-origin Typhimurium (STM) were identified. Whole-genome sequencing (WGS)...
Pseudorabies virus (PRV) causes high mortality and miscarriage rates in the infected swine, eradication policy coupled with large-scale vaccination of live attenuated vaccines has been adopted globally against PRV. Differential diagnosis vaccinated swine is highly demanded. Our multienzyme isothermal rapid amplification (MIRA)-Cas12a detection method described this study can diagnose PRV a superior sensitivity comparable to quantitative PCR (qPCR) competitive speed (only half time as qPCR...
Significance Hematopoiesis involves the control of gene expression that regulates processes proliferation and differentiation. We found chromatin remodeler CHD7 controls differentiation process. Knockdown or knockout leads to enhanced hematopoietic in zebrafish mice, suggesting acts as a brake on associated with terminally differentiated blood cells.
Hematopoietic stem cells (HSCs) mature from pre-HSCs that originate in the major arteries of embryo. To identify HSCs vitro sources, it will be necessary to refine markers matured ex vivo. We purified and compared transcriptomes pre-HSCs, vivo, fetal liver HSCs. found HSC maturation vivo or is accompanied by down-regulation genes involved embryonic development vasculogenesis, up-regulation hematopoietic organ development, lymphoid immune responses. Ex more closely resemble than but are not...
Ischemic stroke results in blood-brain barrier (BBB) disruption, during which the reciprocal interaction between ischemic neurons and components of BBB appears to play a critical role. However, underlying mechanisms for protection remain largely unknown. In this study, we found that Serpina3n, serine protease inhibitor, was significantly upregulated brain, predominantly from 6 hours 3 days after stroke. Using neuron-specific adeno-associated virus (AAV), intranasal delivery recombinant...
Influenza A virus (IAV) expresses several accessory proteins to limit host anti-viral restriction factors facilitate viral replication. The Ten-Eleven Translocation 2 (TET2) is a methylcytosine dioxygenase that promotes DNA demethylation by catalyzing the oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), which plays vital role in hematopoiesis and immunity. Here we report TET2 factor limits IAV But endoribonuclease PA-X able remove replication binding mRNA driving...
45,X/46,XY mosaicism is the most common type of sex chromosomal abnormality in disorders development (DSD). We investigated clinical manifestations, serum hormone levels and growth data 38 patients, which provides better insight into this disease. prospectively evaluated patients who were diagnosed with at Department Endocrinology Shanghai Children's Hospital from 2010 to 2020. analyzed including levels, height, weight, body mass index (BMI) gonadal pathology results. Among cases mosaicism,...
Bacterial exonuclease III (ExoIII), widely acknowledged for specifically targeting double-stranded DNA (dsDNA), has been documented as a repair-associated nuclease with apurinic/apyrimidinic (AP)-endonuclease and 3′→5′ activities. Due to these enzymatic properties, ExoIII broadly applied in molecular biosensors. Here, we demonstrate that ( Escherichia coli ) possesses highly active activities on ssDNA. By using range of ssDNA fluorescence-quenching reporters fluorophore-labeled probes...