A5107594874- Pancreatic function and diabetes
- Proteoglycans and glycosaminoglycans research
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Diabetes Management and Research
- Photoreceptor and optogenetics research
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Trauma Management and Diagnosis
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Erythrocyte Function and Pathophysiology
- Prenatal Substance Exposure Effects
- Cellular transport and secretion
- Cannabis and Cannabinoid Research
- FOXO transcription factor regulation
- Protease and Inhibitor Mechanisms
- Sexual function and dysfunction studies
- Angiogenesis and VEGF in Cancer
- Porphyrin Metabolism and Disorders
- Developmental Biology and Gene Regulation
- Zebrafish Biomedical Research Applications
- Gestational Diabetes Research and Management
- S100 Proteins and Annexins
Brown University
2025
Virginia Commonwealth University
2024
Bowdoin College
2022
Baylor College of Medicine
2021-2022
Stanford University
2021-2022
Oregon Health & Science University
2018-2021
Ho Chi Minh City Medicine and Pharmacy University
2021
Harvard University
2017-2020
Boston Children's Hospital
2017-2020
University of Missouri Hospital
2020
Assistive robots have the potential to support independence, enhance safety, and lower healthcare costs for older adults, as well alleviate demands of their care partners. However, ensuring that these will effectively reliably address end-user needs in long term requires user-specific design factors be considered during robot development process. To identify factors, we embedded Stretch, a mobile manipulator created by Hello Robot Inc., home an adult with motor impairments his partner four...
Abstract The extracellular matrix (ECM) of the brain comprises unique glycan “sulfation codes” that influence neurological function. Perineuronal nets (PNNs) are chondroitin sulfate‐glycosaminoglycan (CS‐GAG) containing matrices enmesh neural networks involved in memory and cognition, loss PNN is reported patients with neurocognitive neuropsychiatric disorders including Alzheimer's disease (AD). Using liquid chromatography tandem mass spectrometry (LC‐MS/MS), we show a clinical diagnosis...
Abstract Background Mitochondrial membrane protein‐associated neurodegeneration (MPAN) is caused by pathogenic sequence variants in C19orf12 . Autosomal recessive inheritance has been demonstrated. We present evidence of autosomal dominant MPAN and propose a mechanism to explain these cases. Methods Two large families with apparently were investigated; additional singleton cases identified. Gene sequencing multiplex ligation‐dependent probe amplification used characterize the causative...
Background: Prenatal alcohol exposure (PAE) models can cause neurodevelopmental abnormalities like those observed in fetal spectrum disorder (FASD). Previous studies link experimental PAE effects the brain to impaired signaling through insulin/IGF and Notch pathways that mediate neuronal survival, growth, migration, energy metabolism, plasticity. Importantly, concurrent administration of peroxisome proliferator-activated receptor agonists or dietary soy prevented many aspects FASD due their...
β-Cyano-L-alanine (BCA) and γ-glutamyl-β-cyano-L-alanine (GBCA) are the primary antinutritional compounds in Vicia sativa , a high—protein, drought-tolerant legume. While neurotoxicity monogastric animals has been observed, its molecular basis remains largely unknown. In this study, we optimised an vitro assay using retinoic acid-differentiated SH—SY5Y human neuroblastoma cells to assess BCA GBCA toxicity applied TMT-based quantitative proteomics identify dysregulated proteins. treatment...
Pancreatic β-cell death is a critical event in type 1 diabetes, 2 and clinical islet transplantation. We have previously shown that prolonged block of ryanodine receptor (RyR)-gated release from intracellular Ca2+ stores activates calpain-10-dependent apoptosis β-cells. In the present study, we further characterized channel expression function human islets MIN6 line. All three RyR isoforms were identified cells, these endoplasmic reticulum channels observed close proximity to mitochondria....
Background.The periodontal condition has a reciprocal relationship with rheumatoid arthritis (RA).Rheumatoid patients are reported to present more serious disease (PD) as compared non-RA patients.Objectives.This study aimed evaluate the effects of non-surgical treatment on Vietnamese active RA and PD, where clinical characteristics serum indices were interest.Material methods.We conducted randomized trial (RCT) 82 PD.The randomly divided into 2 groups: intervention group, consisting who...
Significance Hematopoiesis involves the control of gene expression that regulates processes proliferation and differentiation. We found chromatin remodeler CHD7 controls differentiation process. Knockdown or knockout leads to enhanced hematopoietic in zebrafish mice, suggesting acts as a brake on associated with terminally differentiated blood cells.
The P23H mutation in rhodopsin (Rho), the rod visual pigment, is most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). fate of misfolded mutant Rho photoreceptors has yet to be elucidated. We generated a new mouse model, which P23H-Rho fused fluorescent protein Tag-RFP-T (P23HhRhoRFP). In heterozygotes, outer segments formed, and wild-type (WT) was properly localized, but mislocalized inner segments. Heterozygotes exhibited slowly progressing retinal...
Luciferase-based reporter assays are powerful tools for monitoring gene expression in cells because of their ultrasensitive detection capacity and wide dynamic range. Here we describe the characterization use a luciferase enzyme derived from marine copepod Metridia family, referred to as TurboLuc (TurboLuc). To develop TurboLuc, wild-type was modified decrease its size, increase brightness, slow luminescent signal decay, provide efficient intracellular expression. determine susceptibility...
Recent findings indicate that growth factor-driven angiogenesis is markedly influenced by genetic variation. This variation in angiogenic responsiveness may alter the susceptibility to a number of angiogenesis-dependent diseases. Here, we utilized diversity available common inbred mouse strains identify loci and candidate genes responsible for differences response. The corneal micropocket neovascularization assay was performed on 42 different using basic fibroblast factor (bFGF) pellets. We...
Abstract Background Tauopathy and α‐synucleinopathy often occur together in human brain diseases but most commonly the context of β‐amyloidosis. induced by absence β‐amyloid has been demonstrated vitro cultured cells compelling examples this disease rarely occur, familial Parkinson's due to mutations α‐synuclein gene. Mitochondrial protein‐associated neurodegeneration (MPAN) C19orf12 produces with iron accumulation as well widespread α‐synucleinopathy. We report here on findings significance...
1General Surgery, University of British Columbia, Port Coquitlam/CANADA, 2Surgery, California, San Francisco, Francisco/UNITED STATES OF AMERICA, 3University Francisco/CA/UNITED AMERICA
Abstract Introduction/Objective High-risk endometrial carcinomas comprise only 15% of all uterine malignancies but are responsible for over 50% deaths. Hepatoid the endometrium (HME) rare entities with a distinct morphology that is important to recognize because it associated rapid progression and high mortality. Methods We report case HME compare collective review 17 cases from literature. Results A 61-year old female presented post-menopausal bleeding was diagnosed endometrioid carcinoma...
Abstract Much remains to be learned about how cis- regulatory elements such as enhancers function, especially during vertebrate organ development. To increase knowledge in this area, we have examined the cis -regulation of transcription factor dlx2b zebrafish larval tooth formation. We created a GFP knock-in line that replicates expression development and also isolated minimal enhancer (MTE1) sufficient for activating most germ pattern. found four evolutionarily conserved predicted binding...
ABSTRACT HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic variants confer type 2 risk, but a lack experimental systems has limited our understanding how transcription factor HNF1α regulates adult islet function. Here, we combined genetics, RNA sequencing, Cleavage Under Targets & Release Using Nuclease (CUT&RUN) chromatin mapping, patch-clamp electrophysiology transplantation-based assays to elucidate HNF1α-regulated...