A5082893180- Angiogenesis and VEGF in Cancer
- Glaucoma and retinal disorders
- Marine Sponges and Natural Products
- Developmental Biology and Gene Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Connexins and lens biology
- Immune Response and Inflammation
- Coral and Marine Ecosystems Studies
- Neurological Disease Mechanisms and Treatments
- Retinal Diseases and Treatments
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
Boston Children's Hospital
2017-2021
Harvard University
2017-2021
Boston University
2017
Recent findings indicate that growth factor-driven angiogenesis is markedly influenced by genetic variation. This variation in angiogenic responsiveness may alter the susceptibility to a number of angiogenesis-dependent diseases. Here, we utilized diversity available common inbred mouse strains identify loci and candidate genes responsible for differences response. The corneal micropocket neovascularization assay was performed on 42 different using basic fibroblast factor (bFGF) pellets. We...
We have previously used the genetic diversity available in common inbred mouse strains to identify quantitative trait loci (QTLs) responsible for differences angiogenic response using corneal micropocket neovascularization (CoNV) assay. Employing a genome-wide association study (GWAS) approach, region on chromosome 15 containing Basp1 was identified as being significantly associated with angiogenesis strains. Here, we developed unique strategy determine and verify role of BASP1 pathways....