A5051831286- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Oral Health Pathology and Treatment
- Dental Radiography and Imaging
- Bone Metabolism and Diseases
- Dental materials and restorations
- Dental Health and Care Utilization
- Rheumatoid Arthritis Research and Therapies
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Salivary Gland Disorders and Functions
- Bone health and treatments
- Dental Trauma and Treatments
- Systemic Lupus Erythematosus Research
- Fluoride Effects and Removal
- MicroRNA in disease regulation
- interferon and immune responses
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Laser Applications in Dentistry and Medicine
- Cancer Cells and Metastasis
- Dental Research and COVID-19
Ho Chi Minh City Medicine and Pharmacy University
2016-2025
University of California, San Francisco
2024-2025
California State University, Fresno
2024
The University of Tokyo
2020-2024
Chulalongkorn University
2015-2016
University of Florida
2016
Florida College
2016
Extracellular vesicles (EVs), which include exosomes and ectosomes/microvesicles, have emerged as important intercellular regulators. EVs can interact with surface receptors of target cells transport luminal components, including messenger RNAs (mRNAs), microRNAs, enzymes, to the cytosol cell. Here, we show that hematopoietic grown in culture shed exosome-like they differentiate from preosteoclasts into osteoclasts. These were between 25 120 nm (mean, 40 nm) diameter determined by...
Osteoprotegerin (OPG) is a circulating decoy receptor for RANKL, multifunctional cytokine essential the differentiation of tissue-specific cells in bone and immune systems such as osteoclasts, medullary thymic epithelial (mTECs), intestinal microfold (M cells). However, it unknown whether OPG functions only at production site or circulates to other tissues acting an endocrine fashion. Here we explore cellular source by generating OPG-floxed mice show that locally produced OPG, rather than...
Abstract The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing approaches. At distinct anatomical sites, bone tissue harbors multiple types skeletal cells, which may independently supply osteogenic in a site-specific manner. Periosteal (PSCs) growth plate resting zone (RZSCs) critically contribute to intramembranous endochondral formation, respectively. However, it remains unclear whether there is functional crosstalk between these two cells. Here we show...
Abstract The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease humans, immune cells accumulate oral mucosa promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression osteogenic such as osteoblasts periodontal ligament cells. However, detailed mechanism underlying immune–bone periodontitis is not fully understood. Here, we performed single-cell RNA-sequencing analysis on...
In rheumatoid arthritis (RA), osteoclastic bone resorption causes structural joint damage as well periarticular and systemic loss. Periarticular loss is one of the earliest indices RA, often preceding onset clinical symptoms via largely unknown mechanisms. Excessive osteoclastogenesis induced by receptor activator NF-κB ligand (RANKL) expressed synovial fibroblasts erosion, whereas role RANKL lymphocytes in various types has yet to be elucidated. marrow arthritic mice, we found an increase...
ABSTRACT One of the characteristics periodontal ligament (PDL) cells is their plasticity. Yet, underlying mechanisms responsible for this phenomenon are unknown. possible mechanism might be related to epigenetics, since histone deacetylases (HDACs) have been shown play a role in osteoblast differentiation. This study was aimed investigate HDACs osteogenic differentiation human PDL (hPDL) cells. HDAC inhibitor trichostatin A (TSA) had no effect on cell viability as assessed by MTT assay....
Abstract Objective This study aimed to create a 3D-printed customized transfer key and evaluate the accuracy of virtual patient model with maxillomandibular relationship at centric occlusion using key. Methods A was designed, combining facial intraoral (IOS) scans. The design included components that recorded 3D upper lower arch occlusion. image generated in-vitro phantom head soft tissue simulation. Accuracy assessed by superimposing scans reference CBCT images analyzing trueness precision...
Background.The periodontal condition has a reciprocal relationship with rheumatoid arthritis (RA).Rheumatoid patients are reported to present more serious disease (PD) as compared non-RA patients.Objectives.This study aimed evaluate the effects of non-surgical treatment on Vietnamese active RA and PD, where clinical characteristics serum indices were interest.Material methods.We conducted randomized trial (RCT) 82 PD.The randomly divided into 2 groups: intervention group, consisting who...
Abstract Diabetes mellitus (DM) is a known risk factor for severe coccidioidomycosis. Central California has some of the highest rates DM in U.S., according to CDC data. This study examines impact glycemic control on severity and outcomes coccidioidomycosis this high prevalent region. A retrospective analysis was conducted patients with both from 2014-2022 at large referral center Fresno, California. Data collected included demographics, presentation, HbA1c levels, management, outcomes....
Rinsing the mouth with sodium chloride (NaCl) solution is believed to promote healthy gum and improve oral ulcer healing. Scientific evidence support this assumption is, however, lacking. This study aims investigate effect clarify underlying mechanisms of short-term rinsing NaCl on human gingival fibroblast (hGFs) wound Isolated primary hGFs normal keratinocytes (hNOKs) were rinsed 0–7.2% for 2 min, 3 times a day. Scratch-tests, trans-well migration assays MTT activity performed. mRNA...
Oral squamous cell carcinoma (OSCC) carcinogenesis involves heterogeneous tumor cells, and the microenvironment (TME) is highly complex with many different types. Cancer cell-TME interactions are crucial in OSCC progression. Candida albicans (C. albicans)-frequently pre-sent oral potentially malignant disorder (OPMD) lesions tissues-promotes transformation. The aim of study to verify mechanisms underlying car-cinogenesis C. infection identify biomarker for early detection as treatment...
Objective: This study aimed to compare the effects of photobiomodulation therapy (PBMT) on analgesic and inflammatory reduction with that ibuprofen following surgical removal impacted mandibular third molars (IMTMs). Methods: A randomized, split-mouth clinical trial was performed patients undergoing bilateral IMTM removal. PBMT [gallium aluminum arsenide (GaAlAs) laser] specific parameters (wavelength 810 nm, power 0.5% ± 20% W, energy density 4 J/cm2) applied randomly one side mouth...
Cancer-associated fibroblasts (CAFs) and partial epithelial-mesenchymal transition (p-EMT) tumor cells are closed together contribute to the progression of oral squamous cell carcinoma (OSCC). In present study, we deeply analyzed integrated OSCC single-cell RNA sequencing datasets define CAFs p-EMT subpopulations. We highlighted cell-cell interaction network suggested biomarkers for diagnosis prognosis during metastasis condition. The analysis discovered four subtypes CAFs: one population,...
Different restoration materials have different optical characteristics that influence the intraoral scanner's (IOS) image accuracy. The purpose of this
The accuracy of 3D images produced by an intraoral scanner (IOS) is affected the optical characteristics restorative materials such as metal, ceramic, and composite resin. present in vitro study aimed to investigate impact core buildup resin translucency on IOS accuracy.A procedure was performed a proprietary 3D-printed model using injectable resins four groups with different levels (highest lowest: AE, A3, AO3, EX). Ten experimental scans per group were Medit i700 phantom head-mounted...
Objective: This study aimed to survey periodontal status of Vietnamese patients with rheumatoid arthritis (RA) and investigates the association between periodontitis RA in these patients.Materials methods: We conducted a cross-sectional descriptive on 150 another osteoarthritis (OA). was evaluated using DAS28 disease activity score based C-reactive protein levels (DAS28-CRP), classification, serum biomarkers. Periodontal determined indices.Results: The proportion cases group significantly...