A5055448005- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Galectins and Cancer Biology
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Mechanisms of cancer metastasis
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Nuts composition and effects
- Oral health in cancer treatment
- Advanced Proteomics Techniques and Applications
Chi Mei Medical Center
2016-2025
National Yang Ming Chiao Tung University
2015-2025
National Taipei University
2014-2023
Weatherford College
2022
National Cheng Kung University
2020
Tohoku University
2018
Taipei Medical University
2006-2018
The University of Tokyo
2018
Osaka University
2018
Kyoto University
2018
Abstract MicroRNAs offer tools to identify and treat invasive cancers. Using highly isogenic oral squamous cell carcinoma (OSCC) cells, established using in vitro vivo selection protocols from poorly parental populations, we used microarray expression analysis a relative specific decrease miR-491-5p cells. Lower of correlated with poor overall survival patients OSCCs. overexpression OSCC cells suppressed their migratory behavior lung metastatic vivo. We defined the G-protein—coupled receptor...
Significance Oral squamous cell carcinoma (OSCC) accounts for 90% of oral cancers, and earlier detection efficiently increases the survival rate. Here, we used a comprehensive literature review to select candidates LC-multiple reaction monitoring-MS qualitatively quantitatively measure target proteins in saliva samples from individuals at-risk population Taiwan. Statistical analysis results establishes four-protein panel sufficient detect 88.6% early-stage patients 91.6% all with 80.4%...
Virtually all real-valued computations are carried out using floating-point data types and operations. The precision of these must be set with the goals reducing overall round-off error, but also emphasizing performance improvements. Often, a mixed-precision allocation achieves this optimum; unfortunately, there no techniques available to compute such allocations conservatively meet given error target across program inputs. In work, we present rigorous approach based on formal analysis via...
The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis cancer cells. Recently, enzyme SIRT1 has been implicated variety physiological processes; however, its role regulating oral EMT not fully elucidated. Here, we propose mechanism by which sirtuin1 (SIRT1) regulates deacetylating Smad4 repressing effect TGF-β signaling on matrix metalloproteinase-7 (MMP7). roles tumor...
Background: Many single nucleotide polymorphisms (SNPs) have been found to be associated with oral cancer but the biological interactions through SNPs are seldom addressed. In this study, we focused on joint effect for SNP combinations of four DNA repair genes, X‐ray cross‐complementing groups (XRCCs) 1–4, involved in major cancer‐related pathways. Methods: Single polymorphism genotyping was determined using by polymerase chain reaction‐restriction fragment length study (case = 103, control...
J Oral Pathol Med (2010) 39 : 342–348 Background: squamous cell carcinoma (OSCC) is one of the most malignant neoplasms worldwide, and molecular mechanism oral tumorigenesis still unclear. Fatty‐acid‐binding protein 5 (FABP5) was found in our previous study to be upregulated carcinomas by proteomic analysis. The implications FABP5 overexpression cancer progression have not yet been elucidated. Materials methods: In this study, recombinant adeno‐associated virus vectors were used deliver...
Oral cavity squamous cell carcinoma (OSCC), a leading subtype of head and neck cancer, has high global incidence mortality rates. Despite surgery radiochemotherapy, about one-third patients relapse. Targeted immunotherapy options for recurrent OSCC show limited effectiveness, underscoring the need improved treatments. We generated multi-omics datasets from pretreatment samples (n=137) to identify A3A EGFR as markers precise patient stratification. Survival outcomes were assessed by comparing...
Oral squamous cell carcinoma (OSCC) accounts for >90% of cases oral cancer, including cancer at the lip and cavity oropharynx. Most OSCCs develop from potentially malignant disorders (OPMDs), which consist heterogeneous lesions with different transformation potentials that make early detection OSCC a challenge. Using targeted mass spectrometry-based assay to compare multiple candidate proteins, we previously identified matrix metalloproteinase-1 (MMP-1) as one most promising salivary...
Tumor invasion and metastasis represent a major unsolved problem in cancer pathogenesis. Recent studies have indicated the involvement of Src-homology 2 domain-containing tyrosine phosphatase (SHP2) multiple malignancies; however, role SHP2 oral progression has yet to be elucidated. We propose that is involved toward metastasis. expression was evaluated paired tissues by using immunohistochemical staining real-time reverse transcription polymerase chain reaction. Isogenic highly invasive...
Abstract Background Sirtuins (SIRT1-7) are a family of NAD-dependent deacetylases, which play an important role in regulating cancer tumorigenesis; however, their oral has been controversial. SIRT3 is localized the mitochondria, where it deacetylates and activates several enzymes involved cellular redox balance defense against oxidative damage. Results We found that compared with normal human keratinocytes (HOK), highly expressed squamous cell carcinoma (OSCC) lines, but enzymatic...
Although the research on using platelet-rich plasma (PRP) for temporomandibular joint osteoarthritis (TMJ-OA) has advanced, no unified standards exist determining use of arthrocentesis and injection dose frequency PRP. This study aimed to compare efficacy 2 TMJ-OA treatment approaches, plus (A+PRP) PRP alone, attempted provide another potential option with a single mL high-concentration high-purity retrospective matched cohort enrolled 208 patients who were treated disorders (TMDs) in...
Abstract Background Although survival rate and quality of life are improved if patients with oral carcinoma can be detected early, however, such lesions usually asymptomatic; therefore, it is hard to raise awareness. Screening has proved cost‐effective for early detection. Methods Sixty‐two carcinomas 555 potentially malignant disorders (OPMDs) who were through screening examined the relationship between clinicopathological features follow‐up outcomes. Results The 5‐year cumulative...
Oral squamous cell carcinoma (OSCC) carcinogenesis involves heterogeneous tumor cells, and the microenvironment (TME) is highly complex with many different types. Cancer cell-TME interactions are crucial in OSCC progression. Candida albicans (C. albicans)-frequently pre-sent oral potentially malignant disorder (OPMD) lesions tissues-promotes transformation. The aim of study to verify mechanisms underlying car-cinogenesis C. infection identify biomarker for early detection as treatment...
Oral cavity squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and its incidence still increasing. Approximately 50% patients with OSCC die within 5 years after diagnosis, mostly ascribed to fact that majority present advanced stages at time diagnosis.To discover salivary biomarkers for ameliorating detection OSCC, herein, we developed a multiplexed bead-based platform simultaneously detect auto-antibodies (auto-Abs) in samples.Compared healthy individuals, levels...
Oral cancer is one of the most common cancers worldwide, and there are currently no biomarkers approved for aiding its management. Although many potential oral have been discovered, very few verified in body fluid specimens parallel to evaluate their clinical utility. The lack appropriate multiplexed assays chosen targets represents bottlenecks achieving this goal. In present study, we develop a peptide immunoaffinity enrichment-coupled multiple reaction monitoring-mass spectrometry...
Virtually all real-valued computations are carried out using floating-point data types and operations. The precision of these must be set with the goals reducing overall round-off error, but also emphasizing performance improvements. Often, a mixed-precision allocation achieves this optimum; unfortunately, there no techniques available to compute such allocations conservatively meet given error target across program inputs. In work, we present rigorous approach based on formal analysis via...
Oral cancer has consistently been ranked among the top ten cancers in terms of mortality with five year survival rates being lowest for all major cancers. Consequently, great efforts are made to develop new diagnostic tools that can enable early detection a clinical setting. In this study, we report on design and development novel pen-like handheld device, miniaturized tactile sensor mounted front-end integrated portable back-end readout module. The device be used tissue palpation oral...
Saliva is an attractive sample source for the biomarker-based testing of several diseases, especially oral cancer. Here, we sought to apply multiplexed LC-MRM-MS precisely quantify 90 disease-related proteins and assess their intra- interindividual variability in saliva samples from healthy donors.We developed two assays 122 surrogate peptides representing a set proteins. were collected 10 volunteers at three different time points (Day 1 morning afternoon, Day 2 morning). Each was spiked...