A5102782095- Head and Neck Cancer Studies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cutaneous lymphoproliferative disorders research
- Sinusitis and nasal conditions
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Multiferroics and related materials
- Magnetic and transport properties of perovskites and related materials
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Ear and Head Tumors
- Cancer Genomics and Diagnostics
- Magnetic properties of thin films
- Traffic Prediction and Management Techniques
- Immune Cell Function and Interaction
- Advanced Breast Cancer Therapies
- Vascular Tumors and Angiosarcomas
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
Chang Gung Memorial Hospital
2016-2025
National Tsing Hua University
2022-2025
Chang Gung University
2015-2025
Linkou Chang Gung Memorial Hospital
2013-2025
National Taiwan University
2022-2024
University of Maryland, College Park
2022-2024
University of California, Berkeley
2020-2024
National Yang Ming Chiao Tung University
2023
RELX Group (United States)
2023
Taiwan Semiconductor Manufacturing Company (Taiwan)
2022
Abstract As CMOS technologies face challenges in dimensional and voltage scaling, the demand for novel logic devices has never been greater, with spin-based offering scaling potential, at cost of significantly high switching energies. Alternatively, magnetoelectric materials are predicted to enable low-power magnetization control, a solution limited device-level results. Here, we demonstrate voltage-based reading nanodevices room temperature, enabled by exchange coupling between multiferroic...
Rare cases of peripheral T-cell lymphomas with follicular growth pattern (PTCL-F) have been recently reported, and their association t(5;9)(q33;q22) involving ITK SYK has suggested. However, the clinicopathologic aspects PTCL-F are poorly described normal cell counterpart this subgroup lymphoma is still unknown. Therefore, we analyzed pathologic, phenotypic, cytogenetic features a series 30 patients (range: 33 to 88 y) that showed histopathologic in at least 1 biopsy (n=30), either initial...
// Tong-Hong Wang 1 , Yong-Shiang Lin 2 Ying Chen Chau-Ting Yeh 3 Yen-lin Huang Tsung-Han Hsieh Tzong-Ming Shieh 4 Chuen Hsueh 1, Tse-Ching Tissue Bank, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan Department of Anatomic Pathology, University School Medicine, Hepato-Gastroenterology, Liver Research Center, Dental Hygiene, College Health Care, China Medical University, Taichung, Correspondence to: Chuen-Hsueh, e-mail: ch9211@adm.cgmh.org.tw Chen, ctc323@adm.cgmh.org.tw Keywords: long...
The prediction of tumor in the TNM staging (tumor, node, and metastasis) stage colon cancer using most influential histopathology parameters to predict five years disease-free survival (DFS) period machine learning (ML) clinical research have been studied here. From colorectal (CRC) registry Chang Gung Memorial Hospital, Linkou, Taiwan, 4021 patients were selected for analysis. Various ML algorithms applied by considering Tumor Aggression Score (TAS) as a prognostic factor. Performances...
Abstract Purpose: EGFR pathway inhibition may promote anti–programmed cell death protein 1 (PD-1) responses in preclinical models, but how affects tumor antigen presentation during anti–PD-1 monotherapy humans remain unknown. We hypothesized that afatinib, an irreversible tyrosine kinase inhibitor, would improve outcomes patients treated with pembrolizumab for recurrent or metastatic head and neck squamous carcinoma (HNSCC) by promoting immune activation the microenvironment. Patients...
This study evaluated the associations between lymphatic and vascular invasion of oral cavity squamous cell carcinoma (OSCC) clinicopathological manifestations, as well their impact on patient outcomes after treatment. In total, 571 patients with primary OSCC who underwent surgery or without adjuvant therapy were enrolled. Lymphatic found in 28 (5%) 16 (3%) patients, respectively. Significant overall stage (P < 0.001 P = 0.020, respectively), tumor 0.009 0.025, nodal metastasis (both 0.001),...
Abstract Spintronic elements based on spin transfer torque have emerged with potential for on‐chip memory, but they suffer from large energy dissipation due to the current densities required. In contrast, an electric‐field‐driven magneto‐electric storage element can operate capacitive displacement charge and potentially reach 1–10 µJ cm −2 switching operation. Here, of a magnetoresistive is shown, operating at or below 200 mV, pathway get down 100 mV. A combination phase detuning utilized...
A newly introduced pan-immune-inflammation value (PIV) was not evaluated for its role in oral cavity squamous cell carcinoma (OSCC). In this study, the PIV calculated with following equation (neutrophil count × platelet monocyte count)/lymphocyte from results of automated hematology analyzers 853 OSCC patients 2005 to 2017. The optimal cutoff preoperative 268, as determined by a receiver operating characteristic curve. Significant differences were observed alcohol consumption, smoking, pT...
Mutations in the human telomerase reverse transcriptase (TERT) promoter contribute to increased TERT activity. The purpose of present study was assess prevalence mutations oral cavity squamous cell carcinoma (SCC).Total DNA extracted from 201 SCC tumors and adjacent normal tissues. Primers were used amplify sequence region containing 2 (C228T C250T) that then sequenced using Sanger method.Sequencing revealed 52.5% (104/201) 12.9% (26/201) tumor tissues 6.0% (12/201) 2.5% (5/201) contained...
Colorectal cancer is one of the leading causes cancer-related death worldwide. The early diagnosis colon not only reduces mortality but also burden related to treatment strategies such as chemotherapy and/or radiotherapy. However, when microscopic examination suspected tissue sample carried out, it becomes a tedious and time-consuming job for pathologists find abnormality in tissue. In addition, there may be interobserver variability that might lead conflict final diagnosis. As result,...
Oral cavity squamous cell carcinoma (OSCC), a leading subtype of head and neck cancer, has high global incidence mortality rates. Despite surgery radiochemotherapy, about one-third patients relapse. Targeted immunotherapy options for recurrent OSCC show limited effectiveness, underscoring the need improved treatments. We generated multi-omics datasets from pretreatment samples (n=137) to identify A3A EGFR as markers precise patient stratification. Survival outcomes were assessed by comparing...
Abstract Background Accurately matching the correct fascicles in a ruptured mixed nerve is critical for functional recovery. This study investigates use of transcranial magnetic stimulation (TMS) to differentiate motor and sensory nerve. Methods In all 40 rats, median left upper arm was evenly split into three segments. The rats were separated two groups. Group A (20 rats), segment with highest amplitude during TMS selected as neurotizer transferred musculocutaneous B only medial one-third...
Abstract Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative cell lines derived from CSC of two patient-derived xenografts (PDXs), AS-B145, AS-B145-1R, AS-B244, AS-B244-1R, were used to elucidate the role YAP in BCSCs. silenced BCSCs analyzed by proliferation, aldehyde dehydrogenase (ALDH) activity, mammosphere formation, tumorigenesis. The effects modulating IGF-1R...
Stimuli-responsive ion nanochannels have attracted considerable attention in various fields because of their remote controllability ionic transportation. For photoresponsive nanochannels, however, achieving precise regulation conductivity is still challenging, primarily due to the difficulty programmable structural changes confined environments. Moreover, relationship between noncontact photo-stimulation nanoscale and light-induced has not been well understood. In this work, a versatile...
Objective There is no useful tool to clinically predict the occurrence of osteoradionecrosis (ORN) mandible quantitatively. The aim was investigate risk factors, including different modalities radiotherapy, for developing mandibular ORN in patients undergoing marginal mandibulectomy and postoperative radiotherapy. Methods Between January 2006 December 2012, 167 subjects who underwent radiotherapy with were enrolled. association bone measurements patient variables analyzed, a nomogram...
Patients with oral cavity squamous cell carcinoma (OSCC) are frequently first diagnosed at an advanced stage, leading to poor prognosis and high mortality rates. Early detection of OSCC using body fluid-accessible biomarkers may improve the survival rate patients. As tumor interstitial fluid is a proximal enriched cancer-related proteins, it useful reservoir suitable for discovery cancer dysregulated biological pathways in microenvironments. Thus, paired fluids (TIF) adjacent noncancerous...