Curcumin is a polyphenolic compound which possesses anticancer potential. It has been shown to induce cell death in variety of cancer cells, however, its effect on CAL27‑cisplatin-resistant human oral cells (CAR cells) not elucidated date. The low water solubility curcumin leads poor bioavailability, highlighted as major limiting factor. In this study, we utilized water-soluble PLGA nanoparticles (Cur-NPs), and investigated the effects Cur-NPs CAR cells. results showed induced apoptosis but...

Amyloid precursor protein (APP) has been modified by β and γ-secretase that cause amyloid deposits (plaques) in neuronal cells. Glyceraldhyde-derived AGEs identified as a major source of neurotoxicity Alzheimer's disease (AD). In previous study, we demonstrated glyceraldehyde-derived increase APP Aβ via ROS. Furthermore, the combination shown to enhance neurotoxicity. mice, expression is increased tail vein injection AGEs. This evidence suggests correlation between development AD. However,...

// Tong-Hong Wang 1 , Yong-Shiang Lin 2 Ying Chen Chau-Ting Yeh 3 Yen-lin Huang Tsung-Han Hsieh Tzong-Ming Shieh 4 Chuen Hsueh 1, Tse-Ching Tissue Bank, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan Department of Anatomic Pathology, University School Medicine, Hepato-Gastroenterology, Liver Research Center, Dental Hygiene, College Health Care, China Medical University, Taichung, Correspondence to: Chuen-Hsueh, e-mail: ch9211@adm.cgmh.org.tw Chen, ctc323@adm.cgmh.org.tw Keywords: long...

Abstract Oral squamous cell carcinoma (OSCC) is a common malignancy, the incidence of which particularly high in some Asian countries due to geographically linked areca quid (AQ) chewing habit. In this study, array‐based comparative genomic hybridization was used screen microdissected OSCCs for genome‐wide alterations. The highest frequencies gene gain were detected TP63, Serpine1, FGF4/FGF3 , c‐ Myc and DMD. deletion Caspase8 MTAP . Gained genes, classified by hierarchical clustering,...

// Chi-Hao Wu 1, * , Hsin-Yuan Chen Chia-Woei Wang 2, 3, 4, Tzong-Ming Shieh 5 Tsui-Chin Huang 6 Li-Chun Lin 1 Kai-Lee Shih-Min Hsia School of Nutrition and Health Sciences, College Nutrition, Taipei Medical University, Taipei, Taiwan 2 Graduate Institute Clinical Medicine, 3 Department Obstetrics Gynecology, 4 University Hospital, Dental Hygiene, Care, China Taichung, PhD Program for Cancer Biology Drug Discovery, Science Technology, Academia Sinica, These authors contributed equally to...

Recently, increasing numbers of long noncoding RNAs (lncRNAs), with both oncogenic and tumor-suppressive potential, have been found to be aberrantly expressed in various human cancers. However, the function lncRNAs hepatocellular carcinoma (HCC) progression remains largely unknown. In this study, we performed a comprehensive microarray analysis lncRNA expression using HCC specimens. After validation 119 tissues, identified novel tumor suppressor lncRNA, CPS1 intronic transcript 1 (CPS1-IT1)....

Hyperuricemia is the main cause of gout and involved in occurrence many other diseases such as hyperlipidemia hypertension correlated with metabolic disorders. Chrysin a flavonoid compound found naturally honey, propolis, mushrooms has anti-inflammatory antioxidant effects. However, its mechanism action not clear yet. This study investigated chrysin’s anti-hyperuricemic effect hyperuricemia-induced rats fed high-fructose corn syrup. Orally administrated chrysin for 28 consecutive days...

Breast cancer (BC) represents one of the most prevalent malignant threats to women globally. Tumor relapse or metastasis is facilitated by BC stemness progression, contributing tumorigenicity. Therefore, comprehending characteristics progression and underlying molecular mechanisms pivotal for advancement. Hinokitiol (β-thujaplicin), a tropolone-related compound abundant in heartwood cupressaceous plants, exhibits antimicrobial activity. In our study, we employed three cell lines (MDA-MB-231,...

Ovarian cancer is one of the commonest gynecologic malignancies, which has a poor prognosis for patients at advanced stage. Isoliquiritigenin (ISL), an active flavonoid component licorice plant, previously demonstrated antioxidant, anti-inflammatory, and tumor suppressive effects. In this study, we investigated antitumor effect ISL on human ovarian in vitro using cell lines, OVCAR5 ES-2, as model systems. Our results show that significantly inhibited viability cells concentration-...

Corylin is a flavonoid extracted from the nuts of Psoralea corylifolia L. (Fabaceae), which widely used anti-inflammatory and anticancer herb in China. Recent studies revealed antioxidant, anti-inflammatory, bone differentiation-promoting effects corylin. However, there are no examining activity In this study, we cells animal models to examine antitumor corylin on hepatocellular carcinoma (HCC) then studied its downstream regulatory mechanisms. The results showed that significantly inhibited...

Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus reduce halitosis. The aim of this study was evaluate activity 3 different dental root canal sealers with hinokitiol (sealers+H) their physical biological effects. AH Plus (epoxy amine resin-based, AH), Apexit (calcium-hydroxide-based, AP), Canals (zinc-oxide-eugenol-based, CA), were study. original CA exhibited strong anti-methicillin-resistant Staphylococcus...

Isoliquiritigenin (ISL), a natural compound extracted from licorice, has chemopreventive and antitumor activities. The purpose of this study was to investigate the anticancer effect ISL on human oral squamous cell carcinoma (OSCC).The anti-OSCC effects were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, flow cytometry, reverse transcription-polymerase chain reaction, Western blotting, promoter activity, terminal deoxynucleotidyl transferase dUTP nick-end...

Patients with triple-negative breast cancer have few therapeutic strategy options. In this study, we investigated the effect of isoliquiritigenin (ISL) on proliferation cells. We found that treatment ISL inhibited cell line (MDA-MB-231) growth and increased cytotoxicity. reduced cycle progression through reduction cyclin D1 protein expression sub-G1 phase population. The ISL-induced apoptotic population was observed by flow cytometry analysis. Bcl-2 treatment, whereas Bax level increased;...

Honokiol and magnolol are natural components isolated from Magnolia bark that is used in traditional Chinese Japanese herbal medicine. These two isomers as a component of dietary supplements cosmetic products. In this study, we investigated the antimicrobial effect honokiol on pathogens causing oral diseases, their mechanism action biofilm formation drug resistance pathogens, inflammatory regulation mammalian cells. We determined minimum inhibitory concentration bactericidal magnolol,...

The incidence of diabetes mellitus is increasing due to the eating and living habits modern people. As disease progresses, long-term effects can cause microvascular disease, causing dysfunction in different parts body, which, turn, leads complications, such as diabetic neuropathy, nephropathy, retinopathy (DR). DR main vision loss blindness patients. Persistent hyperglycemia may damage retina, induce accumulation inflammatory factors, destroy blood–retinal barrier function. Fucoxanthin (Fx)...