Age‐related macular degeneration (AMD) affects the retinal macula and results in loss of vision, AMD is primary cause blindness severe visual impairment among elderly people worldwide. characterized by accumulation drusen Bruch’s membrane dysfunction pigment epithelial (RPE) cells photoreceptors. The pathogenesis remains unclear, no effective treatment exists. Accumulating evidence indicates that oxidative stress plays a critical role RPE cell AMD. Melatonin an antioxidant scavenges free...

Non-alcoholic fatty liver disease (NAFLD), the most common chronic disease, is closely associated with metabolic syndrome and refers to accumulation of hepatic steatosis not due excess alcohol consumption.

Introduction: Isoliquiritigenin (ISL) is a natural phenolic compound extracted from licorice. Previous studies have shown that ISL potent antioxidant with anti-inflammatory and antitumor activities. The anti-invasive activity of was still unclear. actual causes death for most breast cancer patients were due to the tumor metastasis. Attenuating expression vascular endothelial growth factor (VEGF) matrix metalloproteinases (MMPs) well known prevent Objectives: purpose this study investigate...

The aim of the present study was to determine antibacterial activities phenolic essential oil (EO) compounds hinokitiol, carvacrol, thymol, and menthol against oral pathogens. Aggregatibacter actinomycetemcomitans, Streptococcus mutans, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia. coli were used in this study. minimum inhibitory concentrations (MICs), bactericidal (MBCs), bacterial growth curves, temperature pH stabilities, synergistic effects liquid vapor EO tested....

// Chi-Hao Wu 1, * , Hsin-Yuan Chen Chia-Woei Wang 2, 3, 4, Tzong-Ming Shieh 5 Tsui-Chin Huang 6 Li-Chun Lin 1 Kai-Lee Shih-Min Hsia School of Nutrition and Health Sciences, College Nutrition, Taipei Medical University, Taipei, Taiwan 2 Graduate Institute Clinical Medicine, 3 Department Obstetrics Gynecology, 4 University Hospital, Dental Hygiene, Care, China Taichung, PhD Program for Cancer Biology Drug Discovery, Science Technology, Academia Sinica, These authors contributed equally to...

Hyperuricemia is the main cause of gout and involved in occurrence many other diseases such as hyperlipidemia hypertension correlated with metabolic disorders. Chrysin a flavonoid compound found naturally honey, propolis, mushrooms has anti-inflammatory antioxidant effects. However, its mechanism action not clear yet. This study investigated chrysin’s anti-hyperuricemic effect hyperuricemia-induced rats fed high-fructose corn syrup. Orally administrated chrysin for 28 consecutive days...

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age, characterized by androgen-induced oxidative stress leading to several metabolic disorders. In this study, we investigated the potential therapeutic effect caffeic acid on PCOS and its underlying molecular mechanism. We used human ovarian granulosa cell line (KGN cells) induced hydrogen peroxide (H2O2) examine how influences protein expression stress-induced apoptosis-related markers. Our...

Breast cancer (BC) represents one of the most prevalent malignant threats to women globally. Tumor relapse or metastasis is facilitated by BC stemness progression, contributing tumorigenicity. Therefore, comprehending characteristics progression and underlying molecular mechanisms pivotal for advancement. Hinokitiol (β-thujaplicin), a tropolone-related compound abundant in heartwood cupressaceous plants, exhibits antimicrobial activity. In our study, we employed three cell lines (MDA-MB-231,...

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, antiallergic activities. In the present study, we first report gastroprotective effects of dehulled adlay (DA) seeds, which consist bran (AB) endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with AB AE extracts (ABE AEE),...

Ovarian cancer is one of the commonest gynecologic malignancies, which has a poor prognosis for patients at advanced stage. Isoliquiritigenin (ISL), an active flavonoid component licorice plant, previously demonstrated antioxidant, anti-inflammatory, and tumor suppressive effects. In this study, we investigated antitumor effect ISL on human ovarian in vitro using cell lines, OVCAR5 ES-2, as model systems. Our results show that significantly inhibited viability cells concentration-...

The progression of colorectal cancer has been reported to have a positive correlation with the combination hyperglycemia and hyperinsulinemia in diabetic patients, leading lower survival rate. However, how insulin acts on remains not well understood. purpose this study was explore effect colon cell proliferation its underlying molecular signaling as impact insulin-induced vitro metastasis. Our results showed that markedly promoted proliferation, migration anchorage-independent growth human...

Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus reduce halitosis. The aim of this study was evaluate activity 3 different dental root canal sealers with hinokitiol (sealers+H) their physical biological effects. AH Plus (epoxy amine resin-based, AH), Apexit (calcium-hydroxide-based, AP), Canals (zinc-oxide-eugenol-based, CA), were study. original CA exhibited strong anti-methicillin-resistant Staphylococcus...

Isoliquiritigenin (ISL), a natural compound extracted from licorice, has chemopreventive and antitumor activities. The purpose of this study was to investigate the anticancer effect ISL on human oral squamous cell carcinoma (OSCC).The anti-OSCC effects were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, flow cytometry, reverse transcription-polymerase chain reaction, Western blotting, promoter activity, terminal deoxynucleotidyl transferase dUTP nick-end...

Marine sponges are known to produce numerous bioactive secondary metabolites as defense strategies avoid predation. Manzamine A is a sponge-derived β-carboline-fused pentacyclic alkaloid with various bioactivities, including recently reported anticancer activity on pancreatic cancer. However, its cytotoxicity and mode of action against other tumors remain unclear. In this study, we exhibit that manzamine reduced cell proliferation in several colorectal cancer (CRC) lines. To further...

Patients with triple-negative breast cancer have few therapeutic strategy options. In this study, we investigated the effect of isoliquiritigenin (ISL) on proliferation cells. We found that treatment ISL inhibited cell line (MDA-MB-231) growth and increased cytotoxicity. reduced cycle progression through reduction cyclin D1 protein expression sub-G1 phase population. The ISL-induced apoptotic population was observed by flow cytometry analysis. Bcl-2 treatment, whereas Bax level increased;...