A5067050500- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Anorectal Disease Treatments and Outcomes
- Cancer survivorship and care
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Pelvic and Acetabular Injuries
- Stoma care and complications
- Ureteral procedures and complications
Chang Gung University
2014-2024
Chang Gung Memorial Hospital
2012-2024
Memorial Hospital of South Bend
2024
Soochow University
2024
Taipei Municipal YangMing Hospital
2022-2024
Linkou Chang Gung Memorial Hospital
2009-2021
Ministry of Health and Welfare
2020
Abstract Enumeration of circulating tumor cells (CTCs) has been proven as a prognostic marker for metastatic colorectal cancer (m-CRC) patients. However, the currently available techniques capturing and enumerating CTCs lack required sensitivity to be applicable non-metastatic patients are even more rare. We have developed microfluidic device utilizing antibody-conjugated non-fouling coating eliminate nonspecific binding promote multivalent target cells. then established correlation CTC...
The prediction of tumor in the TNM staging (tumor, node, and metastasis) stage colon cancer using most influential histopathology parameters to predict five years disease-free survival (DFS) period machine learning (ML) clinical research have been studied here. From colorectal (CRC) registry Chang Gung Memorial Hospital, Linkou, Taiwan, 4021 patients were selected for analysis. Various ML algorithms applied by considering Tumor Aggression Score (TAS) as a prognostic factor. Performances...
Abstract Backgrounds Though better short-term outcomes were frequently reported, differences in specimen parameters and the rate of subsequent peritoneal recurrence between intracorporeal anastomosis (IA) extracorporeal anastomoses (EA) for laparoscopic right hemicolectomy have not been analyzed. We aimed to compare pathologic oncological these two approaches. Methods retrospectively analyzed 217 consecutive patients who underwent hemicolectomies from September 2016 April 2018 classified...
Bevacizumab-based regimens are used as standard treatments for colorectal cancer. Unfortunately, there no established predictive markers bevacizumab response.Tumor samples from 36 metastatic cancer patients treated with plus chemotherapy were analyzed by next-generation sequencing of all coding exons more than 400 genes. Single gene and signaling pathway analyses performed to correlate genomic data response.Among the genes most frequently mutated in our cohort, only mutations PTPRT, a...
In Brief Objective: The aim of this study was to investigate the effect body mass index (BMI) on local recurrence primary rectal cancer after open curative sphincter-saving resection. Background: Increasing BMI reported be associated with a higher likelihood in male patients cancer. However, it remained unclear whether exerts same effects upper and lower rectum. Methods: Between January 1995 December 2002, we investigated 1873 well-documented height weight who underwent anterior resection...
Abstract Background Radical resection is associated with good prognosis among patients cT1/T2Nx rectal cancer. However, still some of the experienced cancer recurrence following radical resection. This study tried to identify postoperative risk factors local and distant metastasis separately. Methods retrospective, single-center comprised 279 consecutive from Linkou branch Chang Gung Memorial Hospital in 2005–2016 adenocarcinoma, pT1/T2N0M0 at distance anal verge ≤ 8cm, who received curative...
Abstract Background Approximately 20% of patients with colorectal cancer are initially diagnosed stage IV disease. This study aims to examine the role regional lymph node (LN) status in metastatic (mCRC) respect clinicopathologic features and survival outcomes. Methods We investigated 1147 mCRC had undergone surgical resection primary CRC. A total 167 were placed LN-negative (LN−) group another 980 LN-positive (LN+) group. Results LN+ exhibited a significantly higher rate T4 tumors (p =...
Purpose: Massive hematochezia from acute hemorrhagic rectal ulcer can arise in patients with severe comorbid illness who are bedridden for long periods. If the bleeder is not found and treated immediately, bleeding will cause deterioration of health even threaten life. The results current study show how quickly safely per anal suturing treat ulcer. Methods: From January 2003 to December 2003, records 26 underwent were retrospectively reviewed. identification was confirmed by clinical...
BACKGROUND /AIMS: The aim of this study was to calculate the prevalence elevated carcinoembryonic antigen (CEA) among colorectal cancer (CRC) patients and evaluate prognostic value preoperative serum CEA levels in them.Between 1995 2005, 8,861 consecutive were enrolled from a prospective database. =5ng/mL defined as CEA.In multivariate analysis, correlated with higher ages, circumferential tumors, colon large liver metastasis high-stage (AJCC) tumors. After 44-month median follow-up, found...
Abstract Background Local excision (LE) is a feasible treatment approach for rectal cancers in stage pT1 and presents low pathological risk, whereas total mesorectal (TME) reasonable more advanced cancers. On the basis of pathology findings, surgeons may suggest TME patients receiving LE. This study compared survival outcomes between LE with/without chemoradiation mid cancer pT1/pT2, with highly selective intermediate risk. Methods retrospective included 134 who received 39 underwent risk...
Abstract Background The transvaginal natural orifice specimen extraction (NOSE) approach for right-side colon surgery has been proven to exhibit favorable short-term outcomes. However, thus far, no study reported the advantages of transrectal NOSE surgery. aim this was compare technical feasibility, safety, and outcomes minimally invasive right hemicolectomy using method those conventional mini-laparotomy extraction. Methods A conducted on consecutive patients who had either malignancy or...
Abstract Background Laparoscopic surgery has achieved significant results in elderly patients with colorectal cancer (CRC). In this study, we compared the short-term and long-term outcomes of open laparoscopic CRC aged above 75 years at a single tertiary medical center. Methods We analyzed 967 who underwent curative resection for primary adenocarcinoma without distant metastasis between January 2009 December 2015, institution. Of enrolled patients, 305 surgery, 662 received laparotomy...
Background: Because methods of performing laparoscopic left hemicolectomy differ between surgeons, standardizing the procedure is crucial to reduce complications and secure good oncologic outcomes. Materials Methods: This a retrospective hospital-based cohort study using propensity score–weighted method. was conducted at department colorectal surgery in tertiary teaching hospital October 2007 December 2017. The short-term long-term outcomes open from 10 years experience standardized 4-step...
We aim to investigate whether a difference exists between right-sided and left-sided colon cancer at the same disease stage subsequent liver metastasis identify tumor location can independently influence survival.Right-sided was defined as malignancy arising from cecum transverse colon; splenic flexure sigmoid colon. Clinicopathological features survival data were collected for analysis.Overall, 1442 patients included analysis. The median follow-up time 58.2 months. Patients with had better...
Our purpose was to evaluate the effects of a health education and telephone counseling program on knowledge attitudes about colorectal cancer screening psychological impact positive results.A randomized controlled trial conducted with 2 groups using pretest posttest measures design. Patients results were selected randomly assigned an experimental (n = 51) or control group. Subjects in group received program, while routine care only. assessed before intervention (first visit outpatient) at 4...
(1) Background: Bevacizumab-based regimens are a standard treatment for metastatic colorectal cancer (mCRC) patients, however meaningful clinical biomarkers benefit remain scarce. (2) Methods: Tumor samples from 36 mCRC patients treated with bevacizumab-based chemotherapy underwent comprehensive genomic profiling. Alterations in frequently altered genes and important signaling pathways were correlated progression-free survival (PFS). (3) Results: Overall genetic alteration analysis of...