A5076959026- Congenital Ear and Nasal Anomalies
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Zebrafish Biomedical Research Applications
- Otitis Media and Relapsing Polychondritis
- Immune cells in cancer
- Protein Degradation and Inhibitors
Cancer Research Institute
2009-2020
UPMC Hillman Cancer Center
2009-2020
University of Pennsylvania
2009-2020
National Chung Hsing University
2011
Dartmouth College
2009
Abstract RUNX1 is frequently mutated in myeloid and lymphoid malignancies. It has been shown to negatively regulate Toll-like receptor 4 (TLR4) signaling through nuclear factor κB (NF-κB) lung epithelial cells. Here we show that regulates TLR1/2 TLR4 inflammatory cytokine production by neutrophils. Hematopoietic-specific loss increased the of proinflammatory mediators, including tumor necrosis factor-α (TNF-α), bone marrow neutrophils response agonists. Hematopoietic also resulted profound...
Significance Hematopoiesis involves the control of gene expression that regulates processes proliferation and differentiation. We found chromatin remodeler CHD7 controls differentiation process. Knockdown or knockout leads to enhanced hematopoietic in zebrafish mice, suggesting acts as a brake on associated with terminally differentiated blood cells.
Calcium ions are a well-known essential component for pollen germination and tube elongation. Several calcium-dependent protein kinases (CDPKs) expressed predominantly in mature grains play critical role pollen. However, none of their interacting proteins or downstream substrates has been identified. Using yeast two-hybrid screening, we isolated OsCPK25/26-interacting 30 (OIP30), which is also OIP30 encodes RuvB-like DNA helicase 2 (RuvBL2) that well conserved eukaryotic species from to...