Sumedha Bagga

ORCID: 0000-0003-0588-7432
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About
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Research Areas
  • Hepatitis B Virus Studies
  • Liver Disease Diagnosis and Treatment
  • Hepatitis C virus research
  • Hematopoietic Stem Cell Transplantation
  • Influenza Virus Research Studies
  • Respiratory viral infections research
  • Platelet Disorders and Treatments
  • Acute Myeloid Leukemia Research
  • Acute Kidney Injury Research
  • Vaccine Coverage and Hesitancy
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Autophagy in Disease and Therapy
  • Animal Virus Infections Studies
  • Pancreatic function and diabetes
  • Immune cells in cancer
  • Immune Response and Inflammation
  • Muscle and Compartmental Disorders
  • COVID-19 Clinical Research Studies
  • Viral-associated cancers and disorders
  • Endoplasmic Reticulum Stress and Disease
  • Complement system in diseases
  • Blood groups and transfusion
  • Polyomavirus and related diseases
  • Renal Diseases and Glomerulopathies
  • SARS-CoV-2 and COVID-19 Research

All India Institute of Medical Sciences
2023

Boston University
2022

University of Pennsylvania
2020

Drexel University
2014-2016

Institut de Biologie Moléculaire et Cellulaire
2012

Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.

10.20517/2394-5079.2016.05 article EN Hepatoma Research 2016-07-01

Abstract RUNX1 is frequently mutated in myeloid and lymphoid malignancies. It has been shown to negatively regulate Toll-like receptor 4 (TLR4) signaling through nuclear factor κB (NF-κB) lung epithelial cells. Here we show that regulates TLR1/2 TLR4 inflammatory cytokine production by neutrophils. Hematopoietic-specific loss increased the of proinflammatory mediators, including tumor necrosis factor-α (TNF-α), bone marrow neutrophils response agonists. Hematopoietic also resulted profound...

10.1182/bloodadvances.2019000785 article EN cc-by-nc-nd Blood Advances 2020-03-24

Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An subset aHUS is the anti-factor H associated aHUS. This variant occur due deletion complement factor genes, CFHR1 and CFHR3, along with presence antibodies. However, it point interest note not all patients have CFHR1/R3 deletion. Factor-H has vital role in regulation system, specifically alternate pathway. Therefore, dysregulation system...

10.3389/fimmu.2022.931210 article EN cc-by Frontiers in Immunology 2022-08-23

We present post-vaccination nasal shedding findings from the phase IV, community-based, triple-blinded RCT conducted to assess efficacy of trivalent LAIV and inactivated influenza vaccines in rural north India.

10.1111/irv.13149 article EN cc-by Influenza and Other Respiratory Viruses 2023-06-01

Abstract Patients with familial platelet disorder a predisposition to myeloid malignancy (FPDMM) harbor germline monoallelic mutations in key hematopoietic transcription factor RUNX1. Previous studies of FPDMM have focused on megakaryocyte (Mk) differentiation, and production signaling. However, the effects RUNX1 haploinsufficiency progenitor cells (HPCs) subsequent megakaryopoiesis remains incomplete. To address this issue, we studied induced-pluripotent stem cell (iPSC)-derived HPCs...

10.1101/2020.08.23.260281 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2020-08-24

Increased mortality has been observed in patients who develop acute kidney injury (AKI) the setting of coronavirus disease 2019 (COVID-19), which led to approval extracorporeal support by FDA. We analyzed existing literature compare efficacy and therapeutic benefits various modalities for oXiris membranes CytoSorb cartridge high-flow continuous replacement therapy (HFCKRT). AKI due COVID-19 is mediated a state systemic inflammation (cytokine storm syndrome), leading multiple organ...

10.3390/covid2090088 article EN cc-by COVID 2022-08-30
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