A5063518886- Pancreatic function and diabetes
- Financial Markets and Investment Strategies
- Diabetes and associated disorders
- Corporate Finance and Governance
- Market Dynamics and Volatility
- Auditing, Earnings Management, Governance
- Monetary Policy and Economic Impact
- Diabetes Management and Research
- Diet, Metabolism, and Disease
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Urinary Bladder and Prostate Research
- Pancreatitis Pathology and Treatment
- Cannabis and Cannabinoid Research
- Pancreatic and Hepatic Oncology Research
- Pelvic floor disorders treatments
- Financial Reporting and Valuation Research
- Asthma and respiratory diseases
- Risk Management in Financial Firms
- Integrated Circuits and Semiconductor Failure Analysis
- Working Capital and Financial Performance
- Credit Risk and Financial Regulations
- Advancements in Photolithography Techniques
- Mast cells and histamine
- Financial Risk and Volatility Modeling
Stanford University
2019-2024
University of California, San Diego
1994-2019
Baylor University
2014-2018
Fudan University
2018
MultiCare Health System
2018
UC San Diego Health System
2018
Shanghai Jiao Tong University
2004-2017
Shanghai Advanced Research Institute
2017
Chinese University of Hong Kong
2009-2014
University of Chicago
2011-2014
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing biology and enabling new insights into the physiology human organs. We created a reference atlas comprising nearly 500,000 cells from 24 different tissues organs, many same donor. This enabled molecular more than 400 types, their distribution across tissues, tissue-specific variation in gene expression. Using multiple single donor identification clonal T between mutation rate B cells,...
Abstract Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept identify cell types origin using the Tabula Sapiens transcriptomic atlas as well individual atlases in combination with Human Protein Atlas consensus dataset. define type signature scores, which allow inference that contribute cell-free for a variety diseases.
The introduction of robotic surgical systems and their integration into minimally invasive procedures have changed the landscape laparoscopic surgery dramatically. Intuitive Surgical's da Vinci Surgical System was first approved by Food Drug Administration for cardiothoracic in late 1990s. This trend quickly spread through other specialties, with urologists as one frontrunners adoption. Subsequently, pediatric adopted robot-assisted selected centers, performing such pyeloplasty ureteropelvic...
Pancreatic islets produce and secrete cytokines chemokines in response to inflammatory metabolic stress. The physiological role of these “isletokines” health disease is largely unknown. We observed that release multiple mediators patients undergoing islet transplants within hours infusion. proinflammatory cytokine interferon-γ–induced protein 10 (IP-10/CXCL10) was among the highest released, high levels correlated with poor transplant outcomes. Transgenic mouse studies confirmed donor...
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, signaling by its very nature connects cells of different organs involves crosstalk hormones. Here, we leverage the organism-wide single transcriptional atlas non-human primate, mouse lemur (Microcebus murinus), to systematically map source target for 84 classes This work uncovers...
The efficacy of islet transplant is compromised by a significant loss mass posttransplant due to an innate inflammatory reaction. We report the use combination etanercept and anakinra (ANA+ETA) block damage in 100 patients undergoing total pancreatectomy with autotransplant. were divided into 3 groups: no treatment (control [CTL]), alone (ETA), or (ANA+ETA). Peritransplant serum samples analyzed for protein markers cytokines. Graft function was assessed fasting blood glucose, basal...
ABSTRACT Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions human diseases such as diabetes mellitus. Similarities of pancreas morphology suggest that porcine developmental biology may have useful homologies. However, little is known about pig development. To fill this knowledge gap, we investigated fetal neonatal at multiple, crucial stages using modern experimental approaches. Purification β-, α-...
This study examines a comprehensive data set of all terrorist activities that directly affected Americans between 1973 and 2003, exploring the reaction hospitality stocks to these events. Hospitality stocks’ returns following events are well in excess those experienced by rest stock market, beating market 10 15 percent per annum. These results persist despite controls for type event, number casualties, location changes risk, resulting impacts on room demand average daily rates. The most...
Bilateral ureteroscopy can be done in 1 sitting, obviating the need for multiple procedures. We analyzed our experience with same session bilateral to determine its safety and efficacy.In this retrospective study of a 9-year period at Emory University Hospital 1,575 consecutive ureteroscopic procedures were done, which 95 (6.0%) as ureteroscopy, thus constituting cohort. performed urolithiasis 71 cases, urothelial carcinoma 9, ureteral stricture 2 another indication 13. Patients followed...
Pulmonary embolism (PE) complicates 1% to 10% of total joint arthroplasties and generally requires immediate anticoagulation. Low-molecular-weight heparins have supplanted unfractionated heparin as the treatment choice for PE hold a 1A recommendation from American College Chest Physicians this indication. However, complications enoxaparin begun in close proximity arthroplasty surgery are not well described. We examined records 135 patients who underwent arthroplasty, experienced an...
Muscle architecture, or the arrangement of sarcomeres and fibers within muscles, defines functional capacity. There are limited data that provide an understanding hip short external rotator muscle architecture. The purpose this study was thus to characterize architecture these small muscles.Eight muscles from 10 independent human cadaver hips were used in (n = 80 muscles). Architectural measurements made on pectineus, piriformis, gemelli, obturators, quadratus femoris, gluteus minimus. mass,...
Total pancreatectomy with islet autotransplantation (TPIAT) is a promising treatment for refractory chronic pancreatitis. Predictable biomarkers the endocrine function after transplantation would be helpful in selecting patients TPIAT. This study aims to identify novel predicting outcome of isolation and TPIAT patients.This paper studied microRNA 31 11 deceased donors from plasma samples before MiR-7, miR-200a, miR-200c, miR-320, miR-375 were analyzed along patient characteristics outcomes...
Abstract We study the impact of analyst forecasts on prices to determine whether investors learn about accuracy. The straight‐forward relationship between supply and price, economic importance market, predictable timing forecast error realizations, high frequency data make crude oil market an interesting advantageous setting. find that rise (fall) when analysts a decrease (increase) in supplies. During 15 minutes following announcements, have been too (low). Importantly, both relationships...
High-quality pancreatic islets are essential for better posttransplantation endocrine function in total pancreatectomy with islet autotransplantation (TPIAT), yet stress during the isolation process affects quality and yield. We analyzed islet-enriched microRNAs (miRNAs) -375 -200c released to assess damage correlated data function. The absolute concentration of miR-375, miR-200c, C-peptide was measured various steps, including digestion, dilution, recombination, purification, bagging, 12...