A5101506507- Sleep and related disorders
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Diverse Approaches in Healthcare and Education Studies
- Adipose Tissue and Metabolism
- Education and Learning Interventions
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Dietary Effects on Health
- Physical Activity and Health
- Education, Safety, and Science Studies
- Health and Wellbeing Research
- CRISPR and Genetic Engineering
- Obstructive Sleep Apnea Research
- Pancreatic function and diabetes
- Head and Neck Surgical Oncology
- Obesity, Physical Activity, Diet
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular and exercise physiology
- Animal Genetics and Reproduction
- Advanced Neuroimaging Techniques and Applications
- Pluripotent Stem Cells Research
- Coffee research and impacts
- Sleep and Work-Related Fatigue
- Craniofacial Disorders and Treatments
Tsukuba International University
2018-2025
University of Tsukuba
2015-2025
University of California, Davis
2017-2024
Electronics and Telecommunications Research Institute
2020
Gyeongsang National University Hospital
2016
Gyeongsang National University
2005-2016
Ibaraki Christian University
2015
Yonsei University
2007-2014
Korea University
2012-2013
Kyungil University
2013
Abstract Exercise can improve sleep by reducing latency and increasing slow-wave (SWS). Some studies, however, report adverse effects of exercise on architecture, possibly due to a wide variety experimental conditions used. We examined the effect quality using standardized parameters novel analytical methods. In cross-over intervention study we 60 min vigorous at 60% $$\dot{V}{\text{O}}_{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mover> <mml:mi>V</mml:mi>...
Abstract Although recent studies have examined the bidirectional associations between physical activity and sleep parameters, few focused on older adults utilizing objective assessments, such as polysomnography. This micro-longitudinal observational study included 92 Japanese (aged 65–86 years) who underwent evaluations of quality using polysomnography completed subjective sleep-related questionnaires. Activity levels were assessed an accelerometer. Polysomnography, questionnaires,...
As part of the growing lifestyle diversity in modern society, there is wide variation time day individuals choose to exercise. Recent surveys US and Japan have reported that on weekdays, more people exercise evening, with fewer exercising morning or afternoon. Exercise performed post-prandial state has little effect accumulated fat oxidation over 24 h (24-h oxidation) when energy intake matched expenditure (energy-balanced condition). The present study explored possibility increases 24-h...
Abstract Genome editing using programmable nucleases has revolutionized biomedical research. CRISPR-Cas9 mediated zygote genome enables high efficient production of knockout animals suitable for studying development and relevant human diseases. Here we report disabling pancreatogenesis in pig embryos via zygotic co-delivery Cas9 mRNA dual sgRNAs targeting the PDX1 gene, which when combined with chimeric-competent pluriopotent stem cells may serve as a platform xeno-generation tissues organs pigs.
Abstract Chlorogenic acids (CGA) are the most abundant polyphenols in coffee. Continuous consumption of CGA reduces body fat and weight. Since energy metabolism sleep controlled by common regulatory factors, might modulate sleep. Lack has been identified as a risk factor for obesity, hypertension type 2 diabetes. The aim this study was to determine effects ingesting over 5 d on quality humans. A total nine healthy subjects (four male five female) completed placebo-controlled, double-blinded,...
Women with ovulatory menstrual cycles show an increase in body temperature the luteal phase, compared follicular particularly during night. Several, albeit not all, studies reported higher energy expenditure phase phase. Q10 of biological reactions lies between 2.0 and 3.0, predicting a 7-12% when rises by 1°C. In this study, dependence was assessed comparing changes sleeping thermoregulation cycle 9 young females. Energy measured using metabolic chamber, which sleep recorded...
Motor skill training promotes the formation of parallel fiber multiple-synapse boutons (MSBs) contacting dendritic spine pairs Purkinje cells in rat cerebellum. However, origin such is unknown. Here, we used three-dimensional electron microscopy reconstruction synaptic connectivity to demonstrate that motor selectively induced MSBs two spines arising from same dendrite, consistent with strengthening local efficacy. excitatory synapses near were smaller motor-trained animals, suggesting...
DDR2 is a receptor tyrosine kinase whose activating ligands are various collagens. DDR2-mediated cellular signaling has been shown to require Src activity. However, the precise mechanism underlying dependence of unknown. Here, using baculoviral co-expression cytosolic domain and Src, we show that targets three residues (Tyr-736, Tyr-740, Tyr-741) in activation loop for phosphorylation. This phosphorylation by stimulates cis-autophosphorylation additional residues. In vitro Shc binding assays...
ABSTRACT Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions human diseases such as diabetes mellitus. Similarities of pancreas morphology suggest that porcine developmental biology may have useful homologies. However, little is known about pig development. To fill this knowledge gap, we investigated fetal neonatal at multiple, crucial stages using modern experimental approaches. Purification β-, α-...
Ingesting oolong tea or caffeine acutely increases energy expenditure, and tea, but not caffeine, stimulates fat oxidation. The acute effects of such as increased heart rate interference with sleep, diminish over 1-4 days, known tolerance. During each 14-day session the present study, 12 non-obese males consumed (100 mg 21.4 gallic acid, 97 catechins 125 polymerized polyphenol), mg), placebo at breakfast lunch. On day 14 session, 24-h indirect calorimetry polysomnographic sleep recording...
Whole body fat oxidation increases during exercise. However, 24-h on a day with exercise often remains similar to that of sedentary day, when energy intake is increased achieve an energy-balanced condition. The present study aimed examine possibility time the performed makes differences in oxidation. As potential mechanism affecting oxidation, its relation exercise-induced transient deficit was examined. Nine young male endurance athletes underwent three trials indirect calorimetry using...
Background Exercise performed in a postprandial state does not increase 24-h fat oxidation of male and female subjects. Conversely, it has been shown subjects that exercise postabsorptive increases compared with sedentary control trials after breakfast, lunch, or dinner. There is paucity study evaluating the effect Method Nine young participated indirect calorimetry measurement over using room-size metabolic chamber which remained 60 min before breakfast at 50% V˙O2max. was accompanied by an...
Mammals have circadian clocks, which consist of the central clock in suprachiasmatic nucleus and peripheral clocks tissues. The effect exercise on phase been reported rodents but not humans. Continuous sampling is necessary to assess rhythm gene expressions. It has assumed that expression genes leukocyte may be "an accessible window multiorgan transcriptome." present study aimed examine whether affects level human leukocytes. Eleven young men participated three trials, they performed a...
Breakfast is often described as “the most important meal of the day” and human studies have revealed that post-prandial responses are dependent on timing, but little known effects timing per se circadian rhythms. We evaluated skipping breakfast for 6 days core body temperature, dim light melatonin onset, heart rate variability, clock gene expression in 10 healthy young men, with a repeated-measures design. Subjects were provided an isocaloric diet three times daily (3M) or two (2M, i.e.,...
Abstract Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the of polychromatic white light using conventional light-emitting diodes (LED) and an alternative source, organic (OLED), producing reduced spectral content in short wavelength blue (455 nm). Ten male participants were exposed to either LED, OLED (1000 lx), or dim (< 10 lx) 4 h before sleep a metabolic chamber....
Significance Insomnia is a common symptom representing an important health burden. Widely prescribed hypnotic agents enhance the function of γ-aminobutyric acid (GABA), major inhibitory neurotransmitter. The ability to arouse and respond unexpected stimuli feature normal sleep, one concerns this class that patients may become physically and/or cognitively impaired while drug in effect. As new approach for treatment insomnia, orexin receptor antagonists have been recently approved, which...
Abstract Introduction Current hypnotic agents have next‐day residual effects. The new orexin antagonist, suvorexant, has little muscle relaxation effect on the physical and cognitive function in following morning daytime. In this study, effects of zolpidem, ramelteon placebo elderly subjects were evaluated. Methods Six men eight women aged 63–75 years received a single tablet lights then turned off. Subjects instructed to sleep from 23:00–6:00 with an interruption 4:00–4:30 for evaluations....