A5040899091- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Fatty Acid Research and Health
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- Gastrointestinal disorders and treatments
- Diet and metabolism studies
- Liver physiology and pathology
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Management and Research
- Appendicitis Diagnosis and Management
- Biliary and Gastrointestinal Fistulas
- Microbial Inactivation Methods
University Hospitals of Leicester NHS Trust
2016-2025
University of Leicester
2012-2024
SRM Institute of Science and Technology
2024
Glenfield Hospital
2023-2024
University Hospitals Coventry and Warwickshire NHS Trust
2023
Birmingham and Midland Eye Centre
2023
National Health Service
2023
University of Bologna
2023
Leicester General Hospital
2013-2022
Royal Australasian College of Surgeons
2022
Objective Currently, there is considerable controversy about the place of transplantation in treatment hepatocellular carcinoma (HCC). This study compared resection to cirrhotic patients with HCC order determine reasonable indications each treatment. Summary Background Data The usual procedure resect when feasible and transplant other cases. Methods Three-year survival without recurrence was analyzed 60 who underwent transplantation. Several prognostic factors, such as size, number nodules,...
Curcumin, a constituent of the spice turmeric, has been shown to reduce adenoma burden in rodent models colorectal cancer accompanied by reduction levels oxidative DNA adduct 3-(2-deoxy-beta-di-erythro-pentafuranosyl)-pyr[1,2-alpha]-purin-10(3H)one (M(1)G) and expression enzyme cyclooxygenase-2 (COX-2). We tested hypothesis that pharmacologically active curcumin can be achieved colorectum humans as measured effects on M(1)G COX-2 protein. Patients with ingested capsules (3,600, 1,800, or 450...
Studies in vitro and animal models of colorectal hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether oral administration results concentrations the agent normal malignant human liver tissue, which are sufficient to elicit pharmacological activity. total, 12 patients with hepatic metastases from cancer received 450–3600 mg daily, for 1 week prior surgery. Levels its metabolites were measured by HPLC portal peripheral...
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate transcriptome 113 single CTCs from 4 different vascular sites, including hepatic vein (HV), peripheral artery (PA), (PV) portal (PoV) using single-cell full-length RNA sequencing in hepatocellular carcinoma (HCC) patients. We reveal that transcriptional dynamics were associated with stress response, cell cycle immune-evasion...
To test the assumption that patients will become unduly anxious if they are given detailed information about risks of surgery in an attempt to obtain fully informed consent.Preoperative anxiety assessed before and after were randomly allocated sheet containing either simple or descriptions possible postoperative complications.Four surgical wards at two Sheffield hospitals.96 men undergoing elective inguinal hernia repair under general anaesthesia.Change level observed receiving potential...
In vitro and pre-clinical studies have suggested that addition of the diet-derived agent curcumin may provide a suitable adjunct to enhance efficacy chemotherapy in models colorectal cancer. However, majority evidence for this currently derives from established cell lines. Here, we utilised patient-derived liver metastases (CRLM) assess whether added benefit over 5-fluorouracil (5-FU) oxaliplatin (FOLFOX) cancer stem (CSC) models. Combination with FOLFOX was then assessed clinically phase I...
Silibinin, a flavonolignan from milk thistle, has intestinal cancer chemopreventive efficacy in rodents. It is strong antioxidant and modulates the insulin-like growth factor (IGF) system by increasing circulating levels of IGF-binding protein 3 (IGFBP-3) decreasing IGF-I. Here, hypothesis was tested that administration oral silibinin generates agent human blood colorectal hepatic tissues consistent with pharmacologic activity. Patients confirmed adenocarcinoma received formulated...
Liver resection strategies have evolved over the past two decades, with a marked shift from major hepatectomies to parenchyma-sparing resections (Figure 46.1). Historically, were norm, practice driven by belief that they necessary for treatment of large tumours or extensive disease. Although still often required, carry higher risk post-hepatectomy liver failure (PHLF) and recent studies demonstrate in western hepato-pancreato-biliary (HPB) centres, proportion has declined 25–30% all...
The aim of this prospective nonrandomized study was to assess the immediate and short-term sequelae transjugular intrahepatic portosystemic shunting on circulatory hyperdynamic state cirrhotic patient. Twelve procedures were performed in 12 patients for sclerotherapy failure (10 cases) and/or intractable ascites (4 cases). Self-expandable stents 10 mm diameter used all cases. Portal pressure measurement right-heart catheterization before 30 min 1 mo after procedure. portoatrial gradient...
The operative management of hilar Cholangiocarcinoma has evolved because advances in diagnostic imaging that have permitted improved patient selection, and refinements techniques lowered mortality rates. Over a 4-year period, 48 patients with were managed. Twenty-seven treated by palliative measures. Preoperative investigation identified 29 who judged fit for operation without proven irresectability radiologic studies, 21 the had tumor removal (72%). Twenty-three procedures performed: local...
In-depth knowledge of pig liver anatomy allows potential research into segmental resections and hepatic regeneration, as well transplantation techniques. The anatomy, however, remains largely unknown. This study aimed to delineate the porcine in comparison with that human.The was determined using acrylic injection casting ex vivo livers, allowing arterial, venous biliary supply be visualized directly. correlated multi-slice computed tomography (CT) three-dimensional reconstructions.Although...
Abstract Naturally occurring anthocyanins possess colorectal cancer chemopreventive properties in rodent models. We investigated whether mirtocyan, an anthocyanin-rich standardized bilberry extract, causes pharmacodynamic changes consistent with efficacy and generates measurable levels of blood, urine, target tissue. Twenty-five patients scheduled to undergo resection primary tumor or liver metastases received mirtocyan 1.4, 2.8, 5.6 grams (containing 0.5-2.0 anthocyanins) daily for 7 days...