A5045246728- Advanced Thermoelectric Materials and Devices
- Single-cell and spatial transcriptomics
- Thermal properties of materials
- Chalcogenide Semiconductor Thin Films
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Cellular Mechanics and Interactions
- Cell Image Analysis Techniques
- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- Thermal Radiation and Cooling Technologies
- Barrier Structure and Function Studies
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Software Testing and Debugging Techniques
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Immune cells in cancer
- interferon and immune responses
- Power Systems and Renewable Energy
- Topological Materials and Phenomena
Southern University of Science and Technology
2022-2025
Stanford University
2020-2025
Qufu Normal University
2024
Shaanxi Normal University
2020-2024
Howard Hughes Medical Institute
2021-2024
University of Toronto
2017-2024
Hospital for Sick Children
2017-2024
National University of Defense Technology
2024
Institute of Biophysics
2011
Chinese Academy of Sciences
2011
The high-entropy concept provides extended, optimized space of a composition, resulting in unusual transport phenomena and excellent thermoelectric performance. By tuning electron phonon localization, we enhanced the figure-of-merit value to 2.7 at 750 kelvin germanium telluride-based materials realized high experimental conversion efficiency 13.3% temperature difference 506 with fabricated segmented module. increasing entropy, increased crystal symmetry delocalized distribution electrons...
Thermoelectrics enable direct heat-to-electricity transformation, but their performance has so far been restricted by the closely coupled carrier and phonon transport. Here, we demonstrate that quantum gaps, a class of planar defects characterized nano-sized potential wells, can decouple transport selectively scattering phonons while allowing carriers to pass effectively. We choose van der Waals gap in GeTe-based materials as representative example illustrate decoupling mechanism. The well...
The integration of artificial intelligence into automated penetration testing (AutoPT) has highlighted the necessity simulation modeling for training intelligent agents, due to its cost-efficiency and swift feedback capabilities. Despite proliferation AutoPT research, there is a recognized gap in availability unified framework methods. This paper presents systematic review synthesis existing techniques, introducing MDCPM categorize studies based on literature objectives, network complexity,...
Animal cells within a tissue typically display striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown. We have previously shown size animal is promoted, part, by size-dependent regulation of G1 length. identify underlying process, we performed large-scale small molecule screen and found p38 MAPK pathway involved coordinating cell cycle progression. Small higher activity spend more time than larger cells. Inhibition leads to loss...
mTORC1 regulates cellular growth and is activated by factors essential amino acids such as Leu. Leu enters cells via the transporter LAT1-4F2hc (LAT1). Here we show that Na+/K+/2Cl- cotransporter NKCC1 (SLC12A2), a known regulator of cell volume, present in complex with LAT1. We further depletion or deletion enhances LAT1 activity, well activation Akt Erk, leading to cells, colonic organoids, mouse colon. Moreover, reduces intracellular Na+ concentration volume (size) mass stimulates...
Abstract The exploration of n‐type PbTe as thermoelectric materials always falls behind its p‐type counterpart, mainly due to their quite different electronic band structure. In this work, elemental Sb and Cu 2 Te are introduced into an base material (PbTe) 81 ‐Sb 3 . introduction extra can effectively tune the concentration electrons; meanwhile, precipitates also scatter low‐energy electrons (negatively contribute Seebeck coefficient) thus enhance overall coefficient. added is found...
In high-entropy materials, local chemical fluctuation from multiple elements inhabiting the same crystallographic site plays a crucial role in their unique properties. Using atomic-resolution mapping, we identified respective contributions of different element characteristics on structures thermoelectric materials. Electronegativity and mass had comparable influence fluctuations constituent elements, while radius made slight contribution. The was further tailored by selecting specific to...
The Origin Recognition Complex (ORC) is a six-subunit protein important for the initiation of DNA replication in eukaryotic cells. Orc6 smallest and least conserved among ORC subunits. It required but also has function cytokinesis metazoan species, however, mechanisms action these processes are not clear. Here we report structure middle domain human Orc6. This an overall fold similar to corresponding helical transcription factor TFIIB. Based on findings, model binding produced. We have...
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, signaling by its very nature connects cells of different organs involves crosstalk hormones. Here, we leverage the organism-wide single transcriptional atlas non-human primate, mouse lemur (Microcebus murinus), to systematically map source target for 84 classes This work uncovers...
Ion channels represent a large class of drug targets, but their role in brain cancer is underexplored. Here, we identify that chloride intracellular channel 1 (CLIC1) overexpressed human central nervous system malignancies, including medulloblastoma, common pediatric cancer. While global knockout does not overtly affect mouse development, genetic deletion CLIC1 suppresses medulloblastoma growth xenograft and genetically engineered models. Mechanistically, enriches to the plasma membrane...
Abstract Lead telluride (PbTe) has long been regarded as an excellent thermoelectric material at intermediate temperature range (573–873 K); however, n‐type PbTe's performance is always relatively inferior to its p‐type counterpart mainly due their different electronic band structures. In this work, ultrahigh quality factor ( µ /κ L ≈ 1.36 × 10 5 cm 3 KJ −1 V ) reported in extra 0.3% Cu doped 0.9 (PbS) 0.1 as‐cast ingots. Transmission electron microscopy (TEM) characterization reveals that...
Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that control involves both checkpoints, which delay cycle progression small cells, size-dependent regulation of mass accumulation rates (Ginzberg et al., 2018). While previously identified the p38 MAPK pathway as key regulator mammalian checkpoint (S. Liu 2018), mechanism rate has remained elusive. Here, quantified global protein...
The development of non-human primate models is essential for the fields developmental and regenerative biology because those will more closely approximate human than do murine models. Based on single cell RNAseq fluorescence-activated sorting, we report identification functional characterization two quiescent stem populations (skeletal muscle cells (MuSCs) mesenchymal termed fibro-adipogenic progenitors (FAPs)) in Microcebus murinus (the gray mouse lemur). We demonstrate vivo proliferation,...
ABSTRACT Mouse lemurs are the smallest, fastest reproducing, and among most abundant primates, an emerging model organism for primate biology, behavior, health conservation. Although much has been learned about their physiology Madagascar ecology phylogeny, little is known cellular molecular biology. Here we used droplet- plate-based single cell RNA-sequencing to profile 226,000 cells from 27 mouse lemur organs tissues opportunistically procured four donors clinically histologically...
Abstract Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. This tight control of involves both checkpoints, which delay cycle progression small cells, size-dependent regulation mass accumulation rates. While we previously identified the p38 MAPK pathway as key regulator mammalian checkpoint, mechanism rate has remained elusive. Here, quantified global rates protein synthesis degradation varying sizes, under...
CuGaTe2 has become a widely studied mid-temperature thermoelectric material due to the advantages of large element abundance, proper band gap, and intrinsically high Seebeck coefficient. However, lattice thermal conductivity low room-temperature electrical result in merely moderate performance for pristine CuGaTe2. In this work, we found that Cu deficiency can significantly reduce activation energy Ea vacancies from ∼0.17 eV nearly zero Cu0.97GaTe2, thus leading dramatic improvements hole...
ABSTRACT Mouse lemurs ( Microcebus spp.) are an emerging primate model organism. However, little is known about their genetics or cellular and molecular biology. In the accompanying paper, we used large-scale single cell RNA-sequencing of 27 organs tissues to identify over 750 types, characterize full transcriptomic profiles, study evolution types. Here use atlas mouse lemur genes, mutations, physiology, disease. We uncover thousands previously unidentified genes hundreds new splice...
ABSTRACT Peripheral glia are important regulators of diverse physiologic functions yet their molecular distinctions and locations in almost all visceral organs not well-understood. We performed a systematic analysis peripheral glia, focusing on the lung leveraging single cell RNA sequencing (scRNA-seq) to characterize cellular features. Using vivo lineage studies, we characterized anatomic, cellular, features Sox10+ glial mouse lung. high-resolution imaging, quantified distribution...