A5045178530- Zebrafish Biomedical Research Applications
- Erythrocyte Function and Pathophysiology
- Single-cell and spatial transcriptomics
- Pregnancy and preeclampsia studies
- Acute Myeloid Leukemia Research
- Immune cells in cancer
- Mesenchymal stem cell research
- Biomarkers in Disease Mechanisms
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Neuropeptides and Animal Physiology
- Hemoglobinopathies and Related Disorders
- Brucella: diagnosis, epidemiology, treatment
- Spaceflight effects on biology
- Chromatin Remodeling and Cancer
- Neuroscience and Neural Engineering
- Endometriosis Research and Treatment
- Muscle activation and electromyography studies
- Pluripotent Stem Cells Research
- Microtubule and mitosis dynamics
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- Erythropoietin and Anemia Treatment
- Immune responses and vaccinations
- Anesthesia and Neurotoxicity Research
University of Pennsylvania
1994-2024
Fios Genomics (United Kingdom)
2023
Cancer Research Institute
2018-2022
Cancer Research Institute of the Slovak Academy of Sciences
2020-2022
Pennsylvania State University
2013-2019
Creighton University
1989
Erythrophagocytosis and the production of proinflammatory cytokines promote stress erythropoiesis during inflammation.
BAY1128688 is a selective inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), an enzyme implicated in the pathology endometriosis and other disorders. In vivo animal studies suggested potential therapeutic application treating endometriosis. Early clinical healthy volunteers supported start phase IIa. This manuscript reports results trial (AKRENDO1) assessing effects adult premenopausal women with endometriosis-related pain symptoms over 12-week treatment period. Participants this...
Summary Hematopoietic stem and progenitor cells (HSPCs) differentiate from hemogenic endothelial (HE) through an to hematopoietic cell transition (EHT). Newly formed HSPCs accumulate in intra-arterial clusters (IACs) before colonizing the fetal liver. To examine molecular transitions during EHT, heterogeneity of within IACs, we profiled ∼37,000 caudal arteries embryonic day 9.5 (E9.5) E11.5 mouse embryos by single-cell transcriptome chromatin accessibility sequencing. We identified...
ABSTRACT Hemogenic endothelial (HE) cells in the dorsal aorta undergo an endothelial-to-hematopoietic transition (EHT) to form multipotent progenitors, lympho-myeloid biased progenitors (LMPs), pre-hematopoietic stem (pre-HSCs) and adult-repopulating HSCs. These briefly accumulate intra-arterial hematopoietic clusters (IAHCs) before being released into circulation. It is generally assumed that number of IAHC correlates with Here, we show changes cells, LMPs HSCs can be uncoupled. Mutations...
Abstract Hemogenic endothelial (HE) cells in the dorsal aorta undergo an to hematopoietic transition (EHT) form lympho-myeloid biased progenitors (LMPs), pre-hematopoietic stem (pre-HSCs) and adult-repopulating HSCs. These briefly accumulate intra-arterial clusters (IAHCs) before being released into circulation. It is generally assumed that number of IAHC correlates with Here we show changes cells, LMPs, HSCs can be uncoupled. Mutations impairing MyD88-dependent toll-like receptor (TLR)...
Abstract Tropomyosins coat actin filaments and impact actin-related signaling cell morphogenesis. Genome-wide association studies have linked Tropomyosin 1 ( TPM1 ) with human blood trait variation. Prior work suggested that regulated formation in vitro, but it was unclear how or when affected hematopoiesis. Using gene-edited induced pluripotent stem (iPSC) model systems, knockout found to augment developmental state transitions, as well TNFα GTPase pathways, promote hemogenic endothelial...