A5015012855- Neuroblastoma Research and Treatments
- Pregnancy and preeclampsia studies
- Renal and related cancers
- Lymphatic System and Diseases
- Kruppel-like factors research
- Vascular Malformations and Hemangiomas
- Tissue Engineering and Regenerative Medicine
- Signaling Pathways in Disease
- Congenital heart defects research
- Birth, Development, and Health
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Zebrafish Biomedical Research Applications
- Empathy and Medical Education
- Neonatal Respiratory Health Research
- Sperm and Testicular Function
- Anatomy and Medical Technology
- Cardiomyopathy and Myosin Studies
- Sympathectomy and Hyperhidrosis Treatments
- Fibroblast Growth Factor Research
- Cell Image Analysis Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Urologic and reproductive health conditions
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
University of Pennsylvania
2021-2024
Cardiovascular Institute of the South
2022
Cardiovascular Institute Hospital
2022
National Heart Lung and Blood Institute
2017-2020
National Institutes of Health
2017-2020
Seattle Children's Hospital
2016
Albert Einstein College of Medicine
2016
Cornell University
2015-2016
Montefiore Medical Center
2016
The University of Texas Health Science Center at San Antonio
2015
Monogenic blood diseases are among the most common genetic disorders worldwide. These result in significant pediatric and adult morbidity, some can death prior to birth. Novel ex vivo hematopoietic stem cell (HSC) gene editing therapies hold tremendous promise alter therapeutic landscape but not without potential limitations. In offer a potentially safer more accessible treatment for these hindered by lack of delivery vectors targeting HSCs, which reside difficult-to-access bone marrow...
microRNA-449a (miR-449a) has been identified to function as a tumor suppressor in several types of cancers. However, the role miR-449a neuroblastoma not intensively investigated. We recently found that overexpression significantly induces cell differentiation, suggesting its potential neuroblastoma. In this study, we further investigated mechanisms underlying suppressive observed inhibits survival and growth through 2 mechanisms—inducing differentiation cycle arrest. Our comprehensive...
Calcific aortic valve (AoV) disease is a significant clinical problem for which the regulatory mechanisms are poorly understood. Enhanced cell-cell adhesion common mechanism of cellular aggregation, but its role in calcific lesion formation not known. Cadherin-11 (Cad-11) has been associated with vitro, function during adult homeostasis and pathogenesis This study aims to elucidate specific functions Cad-11 downstream targets, RhoA Sox9, extracellular matrix remodeling AoV calcification.We...
During formation of the mammalian placenta, trophoblasts invade maternal decidua and remodel spiral arteries to bring blood into placenta. This process, known as endovascular invasion, is thought involve adoption functional characteristics vascular endothelial cells (ECs) by trophoblasts. The genetic molecular basis invasion remains poorly defined, however, whether utilize specialized proteins in an analogous manner create channels untested. Vascular (VE-)cadherin a homotypic adhesion...
Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from interstitium. While excessive vascular endothelial growth factor 2 (VEGFR2) signaling can remodel seal these junctions, whether how VEGFR3 alter lymphatic remains incompletely understood. Here, we use lymphatic-specific Flt4 knockout mice to investigate in junctions. We show loss prevents specialized button junction formation multiple tissues...
// Zhenze Zhao 1 , Xiuye Ma 2 Spencer D. Shelton Derek C. Sung 3 Monica Li 4 Daniel Hernandez 5 Maggie Zhang 6 Michael Losiewicz 7 Yidong Chen 8 Alexander Pertsemlidis 2, 9, 10 Xiaojie Yu 11 Yuanhang Liu Liqin Du Department of Chemistry and Biochemistry at Texas State University, San Marcos, Texas, USA Greehey Children's Cancer Research Institute UT Health Science Center Antonio, Division Nutritional Sciences Cornell Ithaca, New York, University Austin, Biology Biology, College Sciences, &...
Nonmuscle myosin IIB (NMIIB; heavy chain encoded by MYH10) is essential for cardiac myocyte cytokinesis. The role of NMIIB in other cells not known. Here, we show that required epicardial formation and functions to support myocardial proliferation coronary vessel development. Ablation results disruption integrity with a loss E-cadherin at cell-cell junctions focal detachment from the myocardium. NMIIB-knockout blebbistatin-treated explants demonstrate impaired mesenchymal cell maturation...
Abstract Normal placental development and angiogenesis are crucial for fetal growth maternal health during pregnancy. However, molecular regulation of has been difficult to study due a lack specific genetic tools that isolate the placenta from embryo yolk sac. To address this gap in knowledge we recently developed Hoxa13 Cre mice which is expressed allantois-derived cells, including endothelial stromal cells. Mice lacking transcriptional regulators Yes-associated protein (YAP) PDZ-binding...
Abstract During formation of the mammalian placenta trophoblasts invade maternal decidua and remodel spiral arteries to bring blood into placenta. This process, known as endovascular invasion, is thought involve adoption functional characteristics vascular endothelial cells (ECs) by through a process termed mimicry. The genetic molecular basis mimicry remains poorly defined, however, whether utilize specialized proteins in an analogous manner create channels untested. Vascular (VE-)cadherin...