A5011974761- RNA modifications and cancer
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- RNA Interference and Gene Delivery
- Mechanisms of cancer metastasis
- Cancer Treatment and Pharmacology
- Genomics and Chromatin Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Neurodegenerative Diseases
- Cell death mechanisms and regulation
- Genomic variations and chromosomal abnormalities
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Neonatal Respiratory Health Research
The University of Texas Health Science Center at Houston
2014-2025
The University of Texas Health Science Center at San Antonio
2014-2025
Emory University
2022-2024
The University of Texas at Austin
2024
The University of Texas Southwestern Medical Center
2024
The University of Texas Medical Branch at Galveston
2024
Cancer Research Institute of the Slovak Academy of Sciences
2015
Children's Cancer Center
2014
Abstract Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and are often observed cancer influence critical pathways implicated tumor initiation growth. Identification characterization oncogenic RBPs their regulatory networks provide new opportunities for targeted therapy. Results We identify the protein SERBP1 a novel regulator glioblastoma (GBM) development. High is prevalent GBMs correlates with poor patient survival...
microRNA-449a (miR-449a) has been identified to function as a tumor suppressor in several types of cancers. However, the role miR-449a neuroblastoma not intensively investigated. We recently found that overexpression significantly induces cell differentiation, suggesting its potential neuroblastoma. In this study, we further investigated mechanisms underlying suppressive observed inhibits survival and growth through 2 mechanisms—inducing differentiation cycle arrest. Our comprehensive...
// Zhenze Zhao 1 , Xiuye Ma Tzu-Hung Hsiao Gregory Lin Adam Kosti Xiaojie Yu 2 Uthra Suresh Yidong Chen 1,3 Gail E. Tomlinson 1,4 Alexander Pertsemlidis 1,4,5 Liqin Du 1,5 Greehey Children's Cancer Research Institute, UT Health Science Center at San Antonio, TX Graduate School of Biomedical Sciences, 3 Department Epidemiology and Biostatistics, 4 Pediatrics, 5 Cellular Structural Biology, Correspondence: Du, email: Keywords : neuroblastoma, microRNA, high-content screen, differentiation,...
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the formation of membraneless organelles such stress granules nucleoli. IDR-RBPs particularly relevant nervous system their dysfunction is associated with neurodegenerative diseases brain tumor development. Serpine1 mRNA-binding protein 1 (SERBP1) a unique...
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the formation of membraneless organelles such stress granules nucleoli. IDR-RBPs particularly relevant nervous system their dysfunction is associated with neurodegenerative diseases brain tumor development. Serpine1 mRNA-binding protein 1 (SERBP1) a unique...
Lung cancer is the leading cause of cancer-related fatalities. Recent success developing genotypically targeted therapies, with potency only in well-defined subpopulations tumors, suggests a path to improving patient survival. We used library oligonucleotide inhibitors microRNAs, class posttranscriptional gene regulators, identify novel synthetic lethal interactions between miRNA inhibition and molecular mechanisms non-small cell lung (NSCLC). Two inhibitors, those for miR-92a miR-1226*,...
RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative antagonistic fashions. We identified Musashi1 (Msi1) miR-137 as of a molecular switch between self-renewal differentiation. Msi1 have opposite patterns functions, is repressed by miR-137. stem-cell protein implicated while functions proneuronal differentiation miRNA. In gliomas, tumor suppressor prooncogenic factor. suggest the balance key determinant cell fate...
Abstract Background The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma’s undifferentiated state. Most their impact comes via the repression a network oncogenic transcription factors. We conducted high-throughput functional siRNA screen in glioblastoma cells identify E74 like ETS factor 4 (ELF4) as leading contributor to phenotypes. Methods In vitro vivo assays were used assess ELF4 on cancer characterized ELF4’s mechanism action...
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RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed tumors with numerous oncogenic RBPs identified recent years. Musashi1 (Msi1) is an RBP and stem cell that controls the balance between self-renewal differentiation. High Msi1 have been multiple including glioblastoma associated poor patient outcomes tumor growth. A comprehensive genomic analysis a network cycle/division DNA replication genes established these processes...
ABSTRACT RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the formation of membraneless organelles such stress granules nucleoli. IDR-RBPs particularly relevant nervous system their dysfunction is associated with neurodegenerative diseases brain tumor development. Serpine1 mRNA-binding protein 1 (SERBP1) a...
Tumor suppressor microRNAs (miRNAs) have been explored as agents to target cancer stem cells. Most strategies use a single miRNA mimic and present many disadvantages, such the amount of reagent required diluted effect on genes. miRNAs work in cooperative fashion regulate distinct biological processes pathways. Therefore, we propose that combinations could provide more efficient ways We previously shown miR-124, miR-128, miR-137 function synergistically neurogenesis. used combination these...
Recent study from our laboratory showed that patients with diabetes are at a higher risk of developing kidney cancer.In the current study, we have screened whole human DNA genome healthy control, or renal cell carcinoma (RCC) RCC+diabetes.We found 883 genes gain/163 loss copy number in RCC+diabetes group, 669 gain/307 RCC group and 458 gain/38 after removing gain/loss obtained control group.Data analyzed for functional annotation enrichment pathways had highest (280) enriched pathways, 191...
Abstract Considerable evidence from mouse models and human postmortem brain suggests loss of Muscleblind-like protein 2 (MBNL2) function in is a major driver CNS symptoms Myotonic dystrophy type 1 (DM1). Increased hypersomnia, fatigue, surgical complications associated with general anesthesia suggest possible sensitivity to GABAergic inhibition DM1. To test the hypothesis that MBNL2 depletion leads behavioral GABA A receptor (GABA -R) modulation, Mbnl2 knock-out (KO) wild-type (WT)...
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the formation of membraneless organelles such stress granules nucleoli. IDR-RBPs particularly relevant nervous system their dysfunction is associated with neurodegenerative diseases brain tumor development. Serpine1 mRNA-binding protein 1 (SERBP1) a unique...
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the formation of membraneless organelles such stress granules nucleoli. IDR-RBPs particularly relevant nervous system their dysfunction is associated with neurodegenerative diseases brain tumor development. SERBP1 a unique member this group, being mostly...
Medulloblastoma is the most common malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved survival recent years, but patients are frequently left devastating neurocognitive other sequelae. Patients molecular subgroups 3 4 still experience a high mortality rate. To identify new pathways contributing to medulloblastoma development create routes for therapy, we have been studying oncogenic RNA-binding proteins. We defined Musashi1 (Msi1) as one of...
<p>Supplementary Figure 1. Activity of miR-92a related inhibitors.</p>
<p>Supplementary Materials. Supplementary tables, figure legends, figures, materials and methods.</p>
<p>Supplementary Figure 3. Transcriptional profiling of HBEC30KT and HBEC30KT-shTP53 identifies context-dependent de-repression the miR-17~92 targetome after p53 loss driven by target genes miR-17-92 polycistron.</p>
<p>Supplementary Figure 2. Expression and response in cells derived from a mouse model of adenocarcinoma.</p>