A5067317296- Lymphatic System and Diseases
- Sympathectomy and Hyperhidrosis Treatments
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Vascular Malformations and Hemangiomas
- Cardiac Arrest and Resuscitation
- Skin and Cellular Biology Research
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
University of South Florida
2019-2024
Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from interstitium. While excessive vascular endothelial growth factor 2 (VEGFR2) signaling can remodel seal these junctions, whether how VEGFR3 alter lymphatic remains incompletely understood. Here, we use lymphatic-specific Flt4 knockout mice to investigate in junctions. We show loss prevents specialized button junction formation multiple tissues...
Lymphatic valves play a critical role in ensuring unidirectional lymph transport. Loss of lymphatic or dysfunctional are associated with several diseases including lymphedema, malformations, obesity, and ileitis. first develop during embryogenesis response to mechanotransduction signaling pathways triggered by oscillatory flow. In blood vessels, eNOS (endothelial NO synthase; gene name:
Lymphatic valves are specialized structures in collecting lymphatic vessels and crucial for preventing retrograde lymph flow. Mutations valve-forming genes have been clinically implicated the pathology of congenital lymphedema. form when oscillatory shear stress from flow signals through PI3K/AKT pathway to promote transcription that trigger growth maintenance valves. Conventionally, many cell types, AKT is phosphorylated at Ser473 by mTORC2 (mammalian target rapamycin complex 2). However,...
Lymphatic valves play a critical role in ensuring unidirectional lymph transport. Loss of lymphatic or dysfunctional are associated with several diseases including lymphedema, malformations, obesity, and ileitis. first develop during embryogenesis response to mechanotransduction signaling pathways triggered by oscillatory flow. In blood vessels, eNOS (gene name: Nos3 ) is well characterized shear stress effector, but its valve development remains unexplored.We used global -/- mice cultured...
Abstract Lymphatic valves are specialized structures of the collecting lymphatic vessels and crucial for preventing retrograde lymph flow. Mutations in valve-forming genes have been clinically implicated pathology congenital lymphedema. form when oscillatory shear stress (OSS) from flow signals through PI3K/AKT pathway to promote transcription that trigger growth maintenance throughout life. Conventionally, other tissue types, AKT activation requires dual kinase activity mammalian target...