A5006034931- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Hydrocarbon exploration and reservoir analysis
- RNA Research and Splicing
- Circular RNAs in diseases
- Virus-based gene therapy research
- Paleontology and Stratigraphy of Fossils
- Geochemistry and Elemental Analysis
- Plant Gene Expression Analysis
- Immune Response and Inflammation
- Soil and Unsaturated Flow
- Lymphatic System and Diseases
- Climate change and permafrost
- Catalytic C–H Functionalization Methods
- Nanomaterials for catalytic reactions
- Hippo pathway signaling and YAP/TAZ
- Plant Molecular Biology Research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Reproductive Biology and Fertility
- Spectroscopy and Chemometric Analyses
China Agricultural University
2025
Chinese Academy of Agricultural Sciences
2022-2025
University of Otago
2016-2024
University of Electronic Science and Technology of China
2024
University of Chinese Academy of Sciences
2024
Sichuan Agricultural University
2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Xinjiang Normal University
2024
Ministry of Agriculture and Rural Affairs
2022-2024
Abstract Reported is a highly chemoselective intermolecular annulation of indole‐based biaryls with bromoalkyl alkynes by using palladium/norbornene (Pd/NBE) cooperative catalysis. This reaction realized through sequence Catellani‐type C−H alkylation, alkyne insertion, and indole dearomatization, forming two C(sp 2 )−C(sp 3 ) one bonds in single chemical operation, thus providing diverse range pentacyclic molecules, containing spiroindolenine fragment, good yields excellent functional‐group...
A rice classification method for the fast and non-destructive differentiation of different varieties is significant in research at present. In this study, fluorescence hyperspectral technology combined with machine learning techniques was used to distinguish five by analyzing features Thai jasmine four a similar appearance wavelength range 475–1000 nm. The data were preprocessed first-order derivative (FD) reduce background baseline drift effects samples. Then, principal component analysis...
Myoblasts serve as the fundamental building blocks of muscle fibers, and there is a positive correlation between diameter myofibers during juvenile phase rate growth, which does not change in adulthood. However, molecular mechanisms governing myofiber across various developmental stages goats remain largely unclear. In this study, we examined miRNA expression longissimus dorsi tissue at two distinct ages: one month, period characterized by robust nine months, when development plateaus A...
The clustered regularly interspaced short palindromic repeat (CRISPR) gene editing technique, based on the non-homologous end-joining (NHEJ) repair pathway, has been used to generate knock-outs with variable sizes of small insertion/deletions high efficiency. More precise genome editing, either insertion or deletion a desired fragment, can be done by combining homology-directed-repair (HDR) pathway CRISPR cleavage. However, HDR-mediated knock-in experiments are typically inefficient, and...
Restriction enzymes have two major limitations for cloning: they cannot cleave at any desired location in a DNA sequence and may not uniquely within sequence. In contrast, the clustered regularly interspaced short palindromic repeat (CRISPR)–associated enzyme 9 (Cas9), when coupled with single guide RNAs (sgRNA), has been used vivo to genomes of many species site, enabling generation mutated cell lines animals. The Cas9/sgRNA complex recognizes 17–20 base target which can be as long it is...
Polo-like kinase 1 (Plk1) plays an important role in cell-cycle regulation. Recent work has suggested that Plk1 could be a biomarker of gemcitabine response pancreatic ductal adenocarcinoma (PDAC). Although targeting to treat PDAC been attempted clinical trials, the results were not promising, and mechanisms resistance inhibition is poorly understood. In addition, progression requires further elucidation. Here, we showed was associated with poor outcomes patients PDAC. inducible transgenic...
Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from interstitium. While excessive vascular endothelial growth factor 2 (VEGFR2) signaling can remodel seal these junctions, whether how VEGFR3 alter lymphatic remains incompletely understood. Here, we use lymphatic-specific Flt4 knockout mice to investigate in junctions. We show loss prevents specialized button junction formation multiple tissues...
The soil freezing-thawing characteristic curve (FTCC) can reflect the physical and mechanical properties of soil–water system during (FT) process, which is guiding significance to study moisture, heat matter transport in cold regions. In this study, firstly, according evolution law hysteresis with revealing mechanisms at different stages based on ice-water transformation theory. be divided into four as temperature decreasing. first three are due nucleation electrolyte effects, capillarity...
Puccinia polysora Underw, the pathogen that causes southern corn rust (SCR), delivers effectors to manipulate host immune responses. However, mechanisms by which these modulate defenses are not well characterized. In this study, we found P. effector PpEX is highly upregulated during infection. suppresses plant responses initiated chitin, including activation of mitogen-activated protein kinases (MAPKs) and expression pathogenesis-related (PR) genes. Maize plants transiently expressing...
BACKGROUND: Lymphatic malformations (LMs) are lesions due to inherited or somatic mutations that lead a defective lymphatic vasculature. Activating KRAS have been identified recently in LM patients with lymphedema, chylous ascites, life-threatening chylothorax. In mouse model, associated loss of valves, which has proposed cause chylothorax via retrograde lymph flow into the pleural space. However, mechanisms underlying valves unknown. METHODS: To investigate leading valve loss, we combined...
Leaf senescence is a programmed developmental process orchestrated by many factors, but its molecular regulation not yet fully understood. In this study, novel Oryza sativa premature leaf mutant (ospls1) was examined. Despite normal development in early seedlings, the ospls1 leaves displayed lesion-mimics and senescence, high transpiration rate after tillering. The also showed seed dormancy attributable to physical (defect of micropyle structure) physiological (abscisic acid sensitivity)...
Virus-like particles (VLP) from rabbit hemorrhagic disease virus (RHDV) can be used as a scaffold to facilitate the delivery of antigens induce cell-mediated immune responses. In this study, we investigated response lymphocytic choriomeningitis virus–derived peptide antigen (gp33) delivered by RHDV VLP. The gp33 peptides were incorporated into VLP in 2 different forms, either recombinantly expressed inside (VLP-gp33r) or chemically coupled surface (VLP-gp33c). We showed that VLP-gp33r...
Detailed knowledge of the effects temperature on thermal conductivity ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>λ</mi> </math> ) rocks is essential for investigating geothermal regime basins and their evolution. In this study, id="M2"> four rock types (carbonate, clastic, intrusive, volcanic rocks) were measured at temperatures 25°C, 50°C, 100°C, 150°C, 200°C, 250°C, 300°C using Transient Plane Source (TPS) approach, which accurate to ±3%. Experimental results...
Given the escalating issue of global climate change, it is imperative to comprehend and quantify effects land use change on carbon storage (CS), which pertains not only preservation ecosystem functions but also directly influences equilibrium stability cycle. This study examines correlation between CS forecasts future spatial distribution CS, offers a reference for rational planning watershed space. Focusing Bosten Lake Basin Xinjiang in China, employing simulation (PLUS) model integrated...
China ranks first in apple production worldwide, making the assessment of quality a critical factor agriculture. Sucrose concentration (SC) is key influencing flavor and ripeness apples, serving as an important indicator. Nondestructive SC detection has significant practical value. Currently, mainly measured using handheld refractometers, hydrometers, electronic tongues, saccharimeter analyses, which are not only time-consuming labor-intensive but also destructive to sample. Therefore, rapid...
The living environment of marine plankton and benthos has been affected by reclamation projects. investigation in Tianjin Harbor Industrial Zone was carried out three times from 2006 to 2008. results showed that the Shannon-Weaver diversity index phytoplankton zooplankton decreased 3.01 1.71 1.7 0.58, respectively. In addition, zero 1.28. projects would change organism, decrease biology structure community.
One obstacle to developing an effective therapeutic strategy treat or prevent asthma is that the fundamental causes of are not totally understood. Asthma thought be a chronic TH2 immune-mediated inflammatory disease. Epigenetic changes recognized play role in initiation and maintenance response. MicroRNAs (miRNAs) key epigenetic regulators gene expression, their expression highly regulated, therefore, deregulation miRNAs may important pathogenesis asthma. Profiling circulating miRNA might...
The results of adoptive T‐cell therapies (ACTs) are very encouraging and show clinical evidence that ACT can provide a cure for patients with metastatic disease. However, various response rates long‐term cancer remission have been observed in different trials. types T cells, prior treatment chemotherapy co‐administration other immune‐target found to influence the efficacy ACT. In this study, we investigate ability using CD4 + helper 1 (Th1) cells CD8 cytotoxic lymphocytes (CTLs) reject...
Abstract Reported is a highly chemoselective intermolecular annulation of indole‐based biaryls with bromoalkyl alkynes by using palladium/norbornene (Pd/NBE) cooperative catalysis. This reaction realized through sequence Catellani‐type C−H alkylation, alkyne insertion, and indole dearomatization, forming two C(sp 2 )−C(sp 3 ) one bonds in single chemical operation, thus providing diverse range pentacyclic molecules, containing spiroindolenine fragment, good yields excellent functional‐group...