A5031068952- Anesthesia and Sedative Agents
- Ion channel regulation and function
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Cardiac Arrhythmias and Treatments
- Caveolin-1 and cellular processes
- Congenital Heart Disease Studies
- Galectins and Cancer Biology
- Inflammatory mediators and NSAID effects
- Cardiovascular Issues in Pregnancy
- Antiplatelet Therapy and Cardiovascular Diseases
- Connective tissue disorders research
- Mass Spectrometry Techniques and Applications
- Kawasaki Disease and Coronary Complications
- Cardiomyopathy and Myosin Studies
- Dermatological and Skeletal Disorders
Cleveland Clinic Lerner College of Medicine
2024
Case Western Reserve University
2022-2024
Cornell University
2016-2022
Cleveland Clinic
2022
University School
2022
Weill Cornell Medicine
2018
Montefiore Medical Center
2016
Seattle Children's Hospital
2016
Albert Einstein College of Medicine
2016
Calcific aortic valve (AoV) disease is a significant clinical problem for which the regulatory mechanisms are poorly understood. Enhanced cell-cell adhesion common mechanism of cellular aggregation, but its role in calcific lesion formation not known. Cadherin-11 (Cad-11) has been associated with vitro, function during adult homeostasis and pathogenesis This study aims to elucidate specific functions Cad-11 downstream targets, RhoA Sox9, extracellular matrix remodeling AoV calcification.We...
This study sought to characterize coronary artery disease (CAD) among adults diagnosed with an anomalous aortic origin of a (AAOCA). We hypothesized that coronaries origins have more severe CAD stenosis than normal origins.This single-center 763 AAOCA consisted 620 patients from our cardiac catheterization database (1958-2009) and 273 electronic medical records query (2010-2021). Within left main, anterior descending, circumflex, right arteries, the severity, assessed by invasive or computer...
K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane identify VA-binding site TREK1 channel. The functional importance identified was validated mutagenesis biochemical modification. Molecular dynamics simulations presence found multiple neighboring residues on TM2, TM3, TM4 contribute binding. region contains...
Abstract Objectives: We assessed the effect of anomalous aortic origin a coronary artery on risk early and late postoperative events after or mitral valve replacement in adults. Methods: Between 2005 2022, 29,579 adults underwent surgical at Cleveland Clinic. Among these, 29 had an unrepaired rising anomalously from aorta that was not intervened upon during surgery, 19 (65%) circumflex, 9 (31%) right. Operative outcomes were compared between patients with arteries 87 balancing score (1:3)...
Abstract K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane identify binding site TREK1 channel. The functional importance identified was validated mutagenesis biochemical modification. Molecular dynamic simulations presence found multiple neighboring residues on TM2, TM3 TM4 contribute binding. region contains...