A5100667762- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Microbial infections and disease research
- Brucella: diagnosis, epidemiology, treatment
- RNA and protein synthesis mechanisms
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Bacterial Genetics and Biotechnology
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- Burkholderia infections and melioidosis
- Streptococcal Infections and Treatments
- Trace Elements in Health
- Genomics and Phylogenetic Studies
- Bacterial biofilms and quorum sensing
- Parasitic Infections and Diagnostics
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- Galectins and Cancer Biology
- Infective Endocarditis Diagnosis and Management
- Toxoplasma gondii Research Studies
- Infections and bacterial resistance
- Plant Virus Research Studies
Shanghai Veterinary Research Institute
2016-2025
Chinese Academy of Agricultural Sciences
2016-2025
Henan Polytechnic University
2024
University of South Florida
2015-2024
Tianjin Agricultural University
2023-2024
Inner Mongolia University
2023
South China University of Technology
2022
Anhui Agricultural University
2022
Cotton Research Institute
2018-2019
Florida College
2015
The expression of the Clostridium difficile binary toxin CDT is generally observed in RT027 (ST1) and RT078 (ST11) C. isolates, which are associated with severe infection (CDI). However, we recently reported that non-RT027 non-RT078 strain LC693 (TcdA+TcdB+ CDT+, ST201) caused diarrhea a patient Xiangya Hospital China. C.difficile member Clade 3, this study, identified as RT871 compared its virulence pathogenicity to those R20291 (TcdA+TcdB+CDT+, ST1/RT027), UK6 ST35/RT027), CD630...
Understanding changes in pathogen behavior (e.g. increased virulence, a shift transmission channel) is critical for the public health management of emerging infectious diseases. Genome degradation via gene depletion or inactivation recognized as pathoadaptive feature evolving with host. However, little known about exact role genome affecting pathogenic behavior, and underlying molecular detail has yet to be examined. Using large-scale global avian-restricted Salmonella genomes spanning more...
The widespread chronic enteritis known as Paratuberculosis (PTB) or Johne's disease (JD) is caused by Mycobacterium avium subspecies paratuberculosis (MAP), posing a significant threat to global public health. Given the challenges associated with PTB JD, development and application of vaccines are potentially important for control. aim this study was design multi-epitope vaccine against MAP. A total 198 MAP genomes were analyzed using pan-genome reverse vaccinology approaches. B-cell T-cell...
Abstract The biofilm acts as a protective layer for Streptococcus suis ( S. ), contributing to the development of drug resistance and chronic infections. Autoinducer 2 (AI-2) quorum sensing represents primary regulatory pathway governing formation in . Consequently, targeting AI-2 inhibit promising strategy preventing managing infections caused by This study established small natural product library integrating commercial molecules with Chinese herbal medicine molecules. two products,...
Human guanylate-binding protein 1 (hGBP1) is an interferon-inducible involved in the host immune response against viral infection. In to infection by influenza A virus (IAV), hGBP1 transcript and were significantly upregulated. Overexpression of inhibited IAV replication a dose-dependent manner vitro. The lysine residue at position 51 (K51) was essential for inhibition replication. Mutation K51 resulted that unable inhibit nonstructural (NS1) found interact directly with hGBP1. region...
How fish embryos that develop externally survive microbial attacks is poorly understood. Here, we clearly demonstrated the embryo extract of zebrafish and its early both displayed antimicrobial activity against microbes, including pathogenic Aeromonas hydrophila, phosvitin (Pv), a nutritional protein abundant in eggs, was related to this activity. We also showed recombinant Pv (rPv) acted as pattern recognition receptor capable recognizing signature molecules LPS, lipoteichoic acid,...
The ibeA gene is located on a genomic island, GimA, which involved in the pathogenesis of neonatal meningitis Escherichia coli (NMEC) and avian pathogenic E. (APEC). prevalence APEC collection China was investigated, 20 467 strains (4.3%) were positive. In addition, analysis association reference (ECOR) groups with positive revealed that linked to group B2. DE205B analyzed compared those NMEC, indicated specificity not consistent along pathotypes. invasion chicken embryo fibroblast DF-1...
Avian pathogenic E. coli and human extraintestinal serotypes O1, O2 O18 strains isolated from different hosts are generally located in phylogroup B2 ST complex 95, they share similar genetic characteristics pathogenicity, with no or minimal host specificity. They popular objects for the study of ExPEC pathogenesis recent years. Here, we investigated evolution blueprint APEC pathotype by performing phylogenetic comparative genome analysis avian strain IMT5155 (O2:K1:H5; ST140) other...
Simultaneous Localization and Mapping (SLAM) using LiDAR technology can acquire the point cloud below tree canopy efficiently in real time, Unmanned Aerial Vehicle (UAV-LiDAR) derive of canopy. By registering them, complete 3D structural information trees be obtained for forest inventory. To this end, an improved RANSAC-ICP algorithm registration SLAM UAV-LiDAR at plot scale is proposed study. Firstly, features are extracted transformed into 33-dimensional feature vectors by descriptor FPFH,...
Type III secretion systems (T3SSs) are crucial for bacterial infections because they deliver effector proteins into host cells. The Escherichia coli type system 2 (ETT2) is present in the majority of E. strains, and although it degenerate, ETT2 regulates virulence. An ATPase essential T3SS secretion, but function has not been demonstrated. Here we show that EivC homologous to β subunit F0F1 ATPases possesses activity. To investigate effects on phenotype virulence avian pathogenic (APEC),...
Avian pathogenic Escherichia coli (APEC) causes colibacillosis in avians, resulting considerable losses the poultry industry. APEC showed zoonotic potential initially related to fact that serves as reservoir of virulence genes and antibiotic resistance for other E. coli. Thus, we determine serotypes, phylogenetic groups, distribution, profiles isolates eastern China. A total 230 were isolated from diseased chicken duck with typical symptoms. Serotyping identified O78 (44.78%) was predominant...
The inappropriate use of antibiotics has led to the emergence multidrug-resistant strains. Bacteriophages (phages) have gained renewed attention as promising alternatives or supplements antibiotics. In this study, a lytic avian pathogenic Escherichia coli (APEC) phage designated PEC9 was isolated and purified from chicken farm feces samples. morphology, genomic information, optimal multiplicity infection (MOI), one-step growth curve, thermal stability, pH in vitro antibacterial ability...
p53 is a tumor suppressor that contributes to the host immune response against viral infections in addition its well-established protective role cancer development. In influenza A virus (IAV) infection, activated and plays an essential inhibiting IAV replication. As transcription factor, regulates expression of range downstream responsive genes either directly or indirectly infection. We compared profiles immune-related between IAV-infected wild-type (p53WT) p53-deficient (p53KO) mice gain...
Inappropriate use of antibiotics has accelerated to the emergence multidrug-resistant bacteria, becoming a major health threat. Moreover, bacterial biofilms contribute antibiotic resistance and prolonged infections. Bacteriophage (phage) therapy may provide an alternative strategy for controlling In this study, broad-host-range phage, SHWT1, with lytic activity against Salmonella was isolated, characterized evaluated therapeutic efficacy in vitro vivo . Phage SHWT1 exhibited specific...
ABSTRACT Pullorum disease is a bacterial caused by Salmonella pullorum in chickens, which characterized gastrointestinal infection and diarrhea. In traditional perspectives, research on primarily focused clinical symptoms, epidemiological characteristics, the pathogenic sites. This study, however, approaches subject from standpoint of host genetic basis gut microbiota. For positive negative offspring chicks, are roosters hens hens, respectively, we conducted whole-genome association analysis...
In Simultaneous Localization and Mapping (SLAM) algorithms, the robustness of single sensors is relatively poor. To address this issue, study develops a multi-sensor fusion platform that integrates data from LiDAR, stereo cameras, IMUs, employs advanced algorithms such as ORB-SLAM2 Cartographer for efficient processing map construction. For point cloud data, we apply Iterative Closest Point (ICP) algorithm point-to-point optimization, effectively solving issue large accumulation errors in...
Riemerella anatipestifer infections cause major economic losses in the duck industry. In this study, a trivalent inactivated vaccine of R. anatipestifer, including strains CH3 (serotype 1), NJ3 2), and HXb2 10), was developed. Animal experiments showed that ducks received two immunizations with were 100% protected from challenge any three serotypes (1, 2, or 10). No death clinical signs diarrhea, tremors, limb swelling shown ducks. Also, no bacteria isolated livers brains Furthermore,...
Systemic infections by avian pathogenic Escherichia coli (APEC) are economically devastating to poultry industries worldwide. E. strains belonging serotypes O1, O2, O18 and O78 preferentially associated with colibacillosis. The rfb gene cluster controlling O antigen synthesis is usually various among different serotypes. In present study, the clusters of were characterized compared. Based on serotype-specific genes in cluster, an allele-specific polymerase chain reaction (PCR) assay was...
Streptococcus suis has emerged as an important zoonotic pathogen that causes meningitis, arthritis, septicemia and even sudden death in pigs humans. Quorum sensing is the signaling network for cell-to-cell communication bacterial cells can use to monitor their own population density through production exchange of signal molecules. S-Ribosylhomocysteinase (LuxS) key enzyme involved activated methyl cycle. Autoinducer 2 (AI-2) adduct borate a ribose derivative produced from...
Streptococcus suis serotype 2 (S. 2) is a zoonotic pathogen. It causes meningitis, arthritis, pneumonia and sepsis in pigs, leading to extremely high mortality, which seriously affects public health the development of pig industry. Pyruvate dehydrogenase (PDH) an important sugar metabolism enzyme that widely present microorganisms, mammals higher plants. catalyzes irreversible oxidative decarboxylation pyruvate acetyl-CoA reduces NAD+ NADH. In this study, we found virulence S. ZY05719...
Abstract Background Extraintestinal pathogenic E. coli (ExPEC) represent a phylogenetically diverse group of bacteria which are implicated in large range infections humans and animals. Although subgroups different ExPEC pathotypes, including uropathogenic, newborn meningitis causing, avian (APEC) share number virulence features, there still might be factors specifically contributing to the pathogenesis certain subset strains or distinct pathotype. Thus, we made use suppression subtractive...