A5101566231- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Microbial infections and disease research
- Vector-borne infectious diseases
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Insect symbiosis and bacterial influences
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- Cancer-related Molecular Pathways
- Clostridium difficile and Clostridium perfringens research
- RNA and protein synthesis mechanisms
Shanghai Veterinary Research Institute
2015-2024
Chinese Academy of Agricultural Sciences
2015-2024
Nanjing University of Aeronautics and Astronautics
2024
Chinese Academy of Agricultural Engineering
2022
Tangshan College
2006-2012
Guangxi Medicinal Botanical Garden
2010
Akita University
2010
Shandong University
2007
Human guanylate-binding protein 1 (hGBP1) is an interferon-inducible involved in the host immune response against viral infection. In to infection by influenza A virus (IAV), hGBP1 transcript and were significantly upregulated. Overexpression of inhibited IAV replication a dose-dependent manner vitro. The lysine residue at position 51 (K51) was essential for inhibition replication. Mutation K51 resulted that unable inhibit nonstructural (NS1) found interact directly with hGBP1. region...
Abstract Background Japanese encephalitis virus (JEV) has a significant impact on public health. An estimated three billion people in 'at-risk’ regions remain unvaccinated and the number of individuals certain Asian countries is increasing. Consequently, there an urgent need for development novel therapeutic agents against encephalitis. Nitazoxanide (NTZ) thiazolide anti-infective licensed treatment parasitic gastroenteritis. Recently, NTZ been demonstrated to have antiviral properties. In...
Metagenomic analysis of mosquito-borne and mosquito-specific viruses is useful to understand the viral diversity for surveillance pathogens medical veterinary importance. Yunnan province located at southwest China has rich abundance mosquitoes. Arbovirus not conducted regularly in this particularly animal farms, which have public health as well Here, we analyzed 10 pools mosquitoes belonging Culex tritaeniorhyncus , Aedes aegypti Anopheles sinensis Armigeres subalbatus species, collected...
Marek's disease virus (MDV) is an oncogenic herpesvirus, which causes malignant lymphoma in chickens. The Meq protein of MDV, expressed abundantly MDV-infected cells and (MD) tumor cells, functions as a transcriptional activator has been proposed to play important role transformation. Preliminary studies demonstrated that able bind p53 vitro, using protein-binding assay. This observation prompted us examine whether the interaction between occurs investigate biological significance this...
p53 is a tumor suppressor that contributes to the host immune response against viral infections in addition its well-established protective role cancer development. In influenza A virus (IAV) infection, activated and plays an essential inhibiting IAV replication. As transcription factor, regulates expression of range downstream responsive genes either directly or indirectly infection. We compared profiles immune-related between IAV-infected wild-type (p53WT) p53-deficient (p53KO) mice gain...
Abstract SAMHD1 is a type I interferon (IFN) inducible host innate immunity restriction factor that inhibits an early step of the viral life cycle. The underlying mechanisms transcriptional regulation remains elusive. Here, we report inducing upregulation part intrinsic immune response via TLR3 and RIG-I/MDA5 agonists ultimately induce nuclear translocation 3 (IRF3) protein. Further studies show IRF3 plays major role in upregulating endogenous expression mechanism independent classical...
Japanese encephalitis virus (JEV) genotype dominance has shifted to I (GI) from III (GIII) in China as demonstrated by molecular epidemiological surveillance. In this study, we performed a serological survey JEV-non-vaccinated pigs confirm JEV shift at the sero-epidemiological level. The average ratio of GI/GIII infection was 1.87, suggesting co-circulation GI and GIII infections with being more prevalent China. To gain an insight into reasons for shift, replication kinetics seven...
Japanese encephalitis virus (JEV) genotype I (GI) replicates more efficiently than III (GIII) in birds, and this difference is considered to be one of the reasons for JEV shift. In study, we utilized duck embryo fibroblasts domestic ducklings as vitro vivo models a amplifying avian host identify viral determinants differing replication efficiency between GI GIII strains birds. induced significantly lower levels interferon (IFN)-α β production strains, an effect orrelated with enhanced over...
To investigate the genetic basis of pleuromutilin resistance in coagulase-negative staphylococci porcine origin that do not carry known genes and to determine localization environment identified gene. Plasmid DNA two pleuromutilin-resistant Staphylococcus cohnii simulans isolates was transformed into aureus RN4220. The plasmids were sequenced completely. candidate gene for cloned shuttle vector pAM401. S. RN4220 transformants carrying this recombinant tested their MICs. isolate SA-7 SSI1...
Genotype III (GIII) Japanese encephalitis virus (JEV) predominance has gradually been replaced by genotype I (GI) over the last 20 years in many Asian countries. This shift raises concerns about protective efficacy of (JE) vaccines, as all currently licensed JE vaccines are derived from GIII strains. In this study, we conducted vaccination-challenge protection assays to evaluate cross-protective GI- or GIII-derived against challenge a heterologous using mouse model. Titration neutralizing...
Japanese Encephalitis virus (JEV) is a zoonotic flavivirus that represents the most significant etiology of childhood viral neurological infections throughout Asia. During last 20 years, JEV genotype dominance has shifted from III (GIII) to I (GI). To date, exact mechanism this displacement still not known. Culex (Cx.) mosquitoes are common species in China and play an essential role maintaining enzootic transmission cycle. In study, we used Cx. pipiens as vivo mosquito model explore if...
Porcine Circovirus 2 (PCV2) is a crucial swine pathogen and considered primary causative agent of porcine circovirus-associated diseases (PCVADs), posing serious economic threat to the industry across globe. The world’s biggest agricultural conglomerates have teamed up create giant commercial pig farms Shanghai due proximity this region more affluent lean-pork markets. Since its discovery, PCV2 has displayed extraordinary genetic diversity, genome swiftly evolving through series mutations...
African Swine Fever (ASF) is an acute, highly contagious and deadly infectious disease that has a huge impact on the swine industry. It caused by fever virus (ASFV). The most acute forms of ASF in domestic pigs have mortality rates up to 100%. lack commercial vaccine effective therapeutic drugs brought great challenges prevention control ASF. Current, requires amount detection, so there need for more sensitive accurate detection technology. protein pB602L, as late non-structural protein,...