A5005220583- Coccidia and coccidiosis research
- Veterinary medicine and infectious diseases
- Synthesis and Biological Evaluation
- Analytical Chemistry and Chromatography
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Antimicrobial Peptides and Activities
- Parasitic Infections and Diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial agents and applications
- Insect and Pesticide Research
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects and Assays
- Helminth infection and control
- Pesticide Residue Analysis and Safety
- Traditional Chinese Medicine Analysis
- Synthesis and Reactions of Organic Compounds
- Mosquito-borne diseases and control
- Toxoplasma gondii Research Studies
- Meat and Animal Product Quality
- Water Quality Monitoring and Analysis
- Mass Spectrometry Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
Ministry of Agriculture and Rural Affairs
2018-2024
Shanghai Veterinary Research Institute
2014-2024
Chinese Academy of Agricultural Sciences
2014-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Huazhong Agricultural University
2014
Nanjing Agricultural University
2010-2013
Hebei University of Science and Technology
2009-2011
Fudan University
2007
Hefei Institutes of Physical Science
2005
Abstract Background Japanese encephalitis virus (JEV) has a significant impact on public health. An estimated three billion people in 'at-risk’ regions remain unvaccinated and the number of individuals certain Asian countries is increasing. Consequently, there an urgent need for development novel therapeutic agents against encephalitis. Nitazoxanide (NTZ) thiazolide anti-infective licensed treatment parasitic gastroenteritis. Recently, NTZ been demonstrated to have antiviral properties. In...
Multidrug-resistant (MDR) pathogens pose a serious threat to the health and life of humans, necessitating development new antimicrobial agents. Herein, we develop characterize panel nine amino acid peptides with cation end motif. Bioactivity analysis revealed that short peptide containing "RWWWR" as central motif harboring mirror structure "KXR" unit displayed not only high activity against MDR planktonic bacteria but also clearance rate 92.33% ± 0.58% mature biofilm. Mechanically, target...
Chronic wound infection caused by multidrug-resistant bacteria is a major threat globally, leading to high mortality rates and considerable economic burden. To address it, an innovative supramolecular nanofiber hydrogel (Hydrogel-RL) harboring antimicrobial peptides was developed based on the novel arginine end-tagging peptide (Pep 6) from our recent study, triggering cross-linking. In vitro results demonstrated that Hydrogel-RL can sustain release of Pep 6 up 120 h profiles, which...
Ethanamizuril is a novel triazine compound that exhibits remarkable anticoccidial activity. Owing to its pharmacological properties, this study was conducted evaluate the acute and 30-day oral toxicity of ethanamizuril. In study, ethanamizuril administered once by gavage mice rats. The calculated LD50 values for rats were 5776 4743 mg per kg b.w, respectively, but value male higher than female subchronic fed with diets supplemented 0, 20, 60 or 120 kg-1 30 days. Treatment related clinical...
The emergence of multidrug-resistant microorganisms has been termed one the most common global health threats, emphasizing discovery new antibacterial agents. To address this issue, we engineered peptides harboring "RWWWR" as a central motif plus arginine (R) end-tagging and then tested them in vitro vivo. Our results demonstrate that Pep 6, peptides, shows great potential combating Escherichia coli bacteremia Staphylococcus aureus skin burn infection model, which induces 62–90% reduction...
Eimeria tenella is a highly pathogenic coccidian that causes avian coccidiosis. Both nitromezuril (NZL) and ethanamizuril (EZL) are novel triazine compounds with high anticoccidial activity, but the mechanisms of their action still unclear. This study explored response E. to NZL EZL by changes in protein composition second-generation merozoites. Label-free quantification (LFQ) proteomics merozoites following treatment were studied LC-MS/MS explore action. The identified proteins annotated...
In this study we describe the design, synthesis, and antibacterial activity of novel pleuromutilin analogs. A series new compounds containing piperazine alkylamino or arylamino groups was synthesized. The were characterized via 1H-NMR, 13C-NMR, Fourier transform (FT)-IR MS, further evaluated for their in vitro against seven Gram-positive, one Gram-negative, pathogens. Antibacterial data revealed that all exhibited moderate to good activities sensitive Gram-positive Specifically, 9d displayed...
Eimeria species are intracellular parasites residing inside the intestinal epithelial cell, which cause poultry coccidiosis and result in significant financial losses industry. Genome editing of is immense importance for development vaccines drugs. CRISPR/Cas9 has been utilized manipulating genome tenella ( E. ). Ectopic expression Cas9, i.e., via plasmids, would introduce transgene, substantially limits its application, especially vaccine development. In this study, we initially optimized...
We described the design, synthesis and antimicrobial activities of novel pleuromutilin derivatives with substituted piperazine substrate. Minimum inhibitory concentration (MIC) was used to evaluate activity against six bacteria in vitro, compound 8 potent Staphylococcus aureus epidermidis MIC value 0.0625 μg/ml. 10a 10 b showed similar positive control drugs (tiamulin, erythromycin) S. 0.125 The binding mode tiamulin ribosome pocket correlation between parameters antibacterial activity, more...