A5100349867- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Microbial infections and disease research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Insect symbiosis and bacterial influences
- Streptococcal Infections and Treatments
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Vector-borne infectious diseases
- interferon and immune responses
- Vector-Borne Animal Diseases
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Toxin Mechanisms and Immunotoxins
- Antimicrobial Peptides and Activities
- Nutritional Studies and Diet
- Bacterial Infections and Vaccines
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
Shanghai Veterinary Research Institute
2016-2025
Chinese Academy of Agricultural Sciences
2014-2025
Xinqiao Hospital
2025
Army Medical University
2025
University of South China
2023-2024
Beijing University of Chemical Technology
2022-2024
China-Japan Friendship Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Sun Yat-sen University
2022-2023
Zhejiang Chinese Medical University
2023
Metagenomic analysis of mosquito-borne and mosquito-specific viruses is useful to understand the viral diversity for surveillance pathogens medical veterinary importance. Yunnan province located at southwest China has rich abundance mosquitoes. Arbovirus not conducted regularly in this particularly animal farms, which have public health as well Here, we analyzed 10 pools mosquitoes belonging Culex tritaeniorhyncus , Aedes aegypti Anopheles sinensis Armigeres subalbatus species, collected...
Porcine reproductive and respiratory syndrome (PRRS) is an immunosuppressive disease caused by PRSS virus (PRRSV). PRRSV mainly causes disorders in pregnant sows diseases piglets. Recently, it has emerged as one of the most important pig industry across globe. In this study, we have collected 231 samples from differently sized farms Eastern China 2017 to 2022 investigate epidemic characteristics disease. All were screened RT-PCR analyzed further using Nsp2 ORF5 genes. The result showed that...
This study was conducted to determine the prevalence of antimicrobial resistance in Campylobacter spp. isolates from broilers live bird markets (LBMs). A total 209 (84 jejuni; 125 coli) were recovered 364 broiler cecum samples collected five LBMs Shanghai, China. Minimum inhibitory concentrations 13 antimicrobials determined using agar dilution method. More than 96% resistant quinolones and tetracyclines. high macrolide (erythromycin, 84.0%; azithromycin, 80.8%) observed C. coli, but not...
Introduction Vaccination remains the most effective strategy for preventing and controlling Japanese encephalitis (JE). The virus (JEV) seroconversion has been documented in sheep goats across various countries, with occasional fatal cases occurring among on farms China. Despite widespread use of attenuated live vaccines, efficacy these vaccines protecting against JE uncertain. This study aimed to assess protective currently available genotype I (GI) JEV strains isolated from using a mouse...
Discectomy-induced ferroptosis of nucleus pulposus cells (NPCs) contributes to postoperative lumbar disc herniation (LDH) recurrence and intervertebral degeneration (IDD). We discover that progenitor (NPPCs) could imprint resistance into NPCs through exosome-dependent intercellular transmission miR-221-3p. Based on these findings, we first develop synthetically-tailored NPPC-derived exosomes with enhanced miR-221-3p expression NPC uptake capacity, which are integrated an injectable hydrogel...
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of PRRS, which has important impacts on pig industry. PRRSV infection results in disruption swine leukocyte antigen class I (SLA-I) presentation pathway. In this study, highly pathogenic (HP-PRRSV) inhibited transcription β2-microglobulin (β2M) gene ( B2M ) reduced cellular levels β2M, forms a heterotrimeric complex with SLA-I heavy chain variable peptide plays critical role presentation. HP-PRRSV...
Doxycycline (Dox) is a tetracycline derivative with broad-spectrum antimicrobial activities that used as an effector substance in inducible gene-expression systems. We investigated the antiviral activity of Dox against vesicular stomatitis virus (VSV) infection cultured H1299 cells. at concentrations 1.0–2.0 μg ml−1 significantly inhibited VSV replication and VSV-induced cytopathic effect dose-dependent manners, suggesting may have broader inhibiting viral replication, addition to its...
African Swine Fever (ASF) is an acute, highly contagious and deadly infectious disease that has a huge impact on the swine industry. It caused by fever virus (ASFV). The most acute forms of ASF in domestic pigs have mortality rates up to 100%. lack commercial vaccine effective therapeutic drugs brought great challenges prevention control ASF. Current, requires amount detection, so there need for more sensitive accurate detection technology. protein pB602L, as late non-structural protein,...
Getah virus (GETV), in the genus Alphavirus and family Togaviridae, has been detected throughout world. GETV causes high morbidity mortality newborn piglets, entailing serious economic losses. Therefore, experimental work on detection is necessary. However, due to influence of a variety unavoidable factors, ELISA test for primary screening animal diseases low accuracy results. we optimized recombinant E2 (rE2) protein-based enzyme-linked immunosorbent assay (ELISA) antibodies pig serum. The...
(1) Background: Asians tend to have a regressive midface. Midface augmentation is an effective treatment, and various materials been used as fillers for this purpose. Bio-Oss bone powder has strong positive effect on promoting new regeneration, in the dental field over 30 years. However, it not reported filler midface augmentation. (2) Objective: To evaluate safety efficacy of using treating retrusion resulting nasolabial folds, develop predictive model patient satisfaction. (3) Methods: 85...
Mosquitoes harbour a diversity of viruses and are responsible for several mosquito-borne viral diseases humans animals, thereby leading to major public health concerns, significant economic losses across the globe. Viral metagenomics offers great opportunity bulk analysis genomes retrieved directly from environmental samples. In this study, we performed metagenomic five pools mosquitoes belonging Aedes, Anopheles Culex species, collected different pig farms in vicinity Shanghai, China,...
Palmitoylation of viral proteins is crucial for host-virus interactions. In this study, we examined the palmitoylation Japanese encephalitis virus (JEV) nonstructural protein 2A (NS2A) and observed that NS2A was palmitoylated at C221 residue NS2A. Blocking by introducing a cysteine-to-serine mutation (NS2A/C221S) impaired JEV replication in vitro attenuated virulence mice. NS2A/C221S had no effect on oligomerization membrane-associated activities, but reduced stability accelerated its...
Abstract An important mechanism involved in dry eye (DE) is the association between tear hyperosmolarity and inflammation severity. Inflammation DE might be mediated by NLRP3 inflammasome, which activated exposure to reactive oxygen species (ROS). A combination of carboxymethylcellulose (CMC) α-melanocyte stimulating hormone (α-MSH) may influence through this mechanism, thus avoiding defects signal drug. In study, we assessed whether treatment comprising CMC combined with α-MSH could...