A5046349994- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- melanin and skin pigmentation
- Corneal Surgery and Treatments
- Dermatology and Skin Diseases
- Retinal Imaging and Analysis
- Mesenchymal stem cell research
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ergonomics and Musculoskeletal Disorders
- Neurological Disorders and Treatments
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Ocular Diseases and Behçet’s Syndrome
- Biochemical Analysis and Sensing Techniques
- Advancements in Transdermal Drug Delivery
- Circadian rhythm and melatonin
- Barrier Structure and Function Studies
- RNA regulation and disease
- Regulation of Appetite and Obesity
- Immune Response and Inflammation
- Retinal Development and Disorders
- Immune responses and vaccinations
Tianjin Medical University Eye Hospital
2014-2021
Tianjin Medical University
2014-2021
Brigham and Women's Hospital
2020
Harvard University
2020
Rationale: Corneal transplantation is an effective treatment to corneal blindness. However, the immune rejection imperils allograft survival. An interventional modality urgently needed inhibit and promote In our previous study, subconjunctival injections of bone marrow-derived mesenchymal stem cells (BM-MSCs) into a rat model extended survival for 2 d. this we sought generate IL-10-overexpressing BM-MSCs, aiming boost survival-promoting effects BM-MSCs on allografts explore molecular...
Abstract Dry eye is a highly prevalent, chronic and multifactorial disease that compromises quality of life generates socioeconomic burdens. The pathogenic factors dry (DED) include tear secretion abnormalities, film instability ocular surface inflammation. An effective intervention targeting the needed to control this disease. Here we applied α-Melanocyte-stimulating hormone (α-MSH) twice day scopolamine-induced rat model. results showed α-MSH at different doses ameliorated secretion,...
To detect and analyze the changes on ocular surface tear function in type II diabetic patients with proliferative retinopathy (PDR), an advanced stage of (DR), using conventional ophthalmic tests high-resolution laser scanning confocal microscopy.Fifty-eight diabetes were selected. Based diagnostic criteria classification DR, divided into non-DR (NDR) group PDR group. Thirty-six cataract but no other systemic disease included as non-diabetic controls. All subjected to clinical corneal...
Blood-retinal barrier (BRB) breakdown and vascular leakage is the leading cause of blindness diabetic retinopathy (DR). Hyperglycemia-induced oxidative stress inflammation are primary pathogenic factors this severe DR complication. An effective interventional modality against during early needed to curb BRB leakage. This study sought examine protective effects α-Melanocyte-stimulating hormone (α-MSH) on retina hyperpermeability, electrophysiological dysfunction, morphological deterioration...
Abstract An important mechanism involved in dry eye (DE) is the association between tear hyperosmolarity and inflammation severity. Inflammation DE might be mediated by NLRP3 inflammasome, which activated exposure to reactive oxygen species (ROS). A combination of carboxymethylcellulose (CMC) α-melanocyte stimulating hormone (α-MSH) may influence through this mechanism, thus avoiding defects signal drug. In study, we assessed whether treatment comprising CMC combined with α-MSH could...
Abstract Glutamate excitotoxicity is a common pathology to blinding ischemic retinopathies, such as diabetic retinopathy, glaucoma and central retinal vein or artery occlusion. The development of an effective interventional modality glutamate hence important preventing blindness. Herein we showed that α-melanocyte-stimulating hormone (α-MSH) time-dependently protected against glutamate-induced cell death tissue damage in improved embryonic chicken explant culture system. α-MSH down-regulated...
To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats.The streptozotocin (STZ)-induced rats were randomly divided into 6 groups: diabetes mellitus (DM) group (saline, 3 µL/eye); at low (0.33 µg/µL, µL), medium (1 and high (3 µL) dose groups; vascular endothelial growth factor (VEGF) Trap µL); fibroblast (FGF) µL). Normal control was included. At week 1 4 following induction, the intravitreally injected with corresponding...
Why ocular mucosa is paucibacterial unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted commensal overgrowth, characterized with increased presence of conjunctival Streptococcal spp. The overgrowth correlated susceptibility to P. aeruginosa-induced keratitis. knock-out (KO) mice displayed elevated bacterial burden aeruginosa-infected corneas, altered...
Background The primary pathogenic basis of diabetic retinopathy (DR) is microangiopathy and inflammatory procedure. Studies showed that α-melanocyte stimulating hormone (α-MSH) can play anti-oxidative stress anti-apoptosis effects on retina via intravitreal injection therefore mend blood-retinal barrier (BRB). However, experiment has not yet proved its mechanism. Objective This study was to investigate the protective α-MSH retinal vessel in rats. Methods Ninety clean SD rats...
Background Mesenchymal stem cells (MSCs) have been applied in basic and clinical researches of organ transplantation.Our previous study showed that intravenous injection MSCs prolonged corneal allograft survival rat.However, the effect local administration on rejection remains unclear. Objective The aim this was to investigate subconjunctival rat model keratoplasty. Methods MSCs were isolated cultured from femur tibia bone marrow clean Wistar rats, then identified by induced...
Objective To investigate the effect of contact lens with different water content and diopters on ocular surface physiological state.Methods Twenty-nie patients (58 eyes) ametropia enrolled in Tianjin medical university hospital from May 2012 to December were presented into three groups according their refractive error (low:less than-3.00D; moderate:from-3.00D～-6.00D; high:more than-6.00D).The high group was subdivided two again randomly,one them as well low moderate myopia wearing lenses...
Background Reasearches showed that α-melanocyte-stimulating hormone (α-MSH) inhibits inflammation and ameliorates the ocular surface abnormalities in a scopolamine-induced dry eye rat model, managing effect of sodium carboxymethylcellulose (CMC) on eyes also has been determined.However, whether α-MSH can enhance therapeutic effects CMC remains to be investigated. Objective This study was investigate protective combined with model. Methods Sixty clean female Wistar rats were...