A5101147811- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Animal Nutrition and Physiology
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Probiotics and Fermented Foods
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Livestock and Poultry Management
- Muscle Physiology and Disorders
- Animal Disease Management and Epidemiology
- Salmonella and Campylobacter epidemiology
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genetic diversity and population structure
- Viral Infections and Immunology Research
Shanghai Jiao Tong University
2021-2025
Shandong Academy of Agricultural Sciences
2022
African swine fever virus (ASFV) is a leading cause of worldwide agricultural loss. ASFV highly contagious and lethal disease for both domestic wild pigs, which has brought enormous economic losses to number countries. Conventional methods, such as general polymerase chain reaction isothermal amplification, are time-consuming, instrument-dependent, unsatisfactorily accurate. Therefore, rapid, sensitive, field-deployable detection important surveillance control. Herein, we created one-pot...
ABSTRACT Pullorum disease is a bacterial caused by Salmonella pullorum in chickens, which characterized gastrointestinal infection and diarrhea. In traditional perspectives, research on primarily focused clinical symptoms, epidemiological characteristics, the pathogenic sites. This study, however, approaches subject from standpoint of host genetic basis gut microbiota. For positive negative offspring chicks, are roosters hens hens, respectively, we conducted whole-genome association analysis...
Abstract The Alectoris Chukar (chukar) is the most geographically widespread partridge species in world, demonstrating exceptional adaptability to diverse ecological environments. However, scarcity of genetic resources for chukar has hindered research into its adaptive evolution and molecular breeding. In this study, we have sequenced assembled a high-quality, phased genome that consists 31 pairs relatively complete diploid chromosomes. Our BUSCO analysis reported high completeness score...
In the avian species, genetic modification by cell nuclear transfer is infeasible due to its unique reproductive system. The in vitro primordial germ approach difficult and cumbersome, although it main method of chickens. present study, adenoviral CRISPR/Cas9 vector was directly microinjected into dorsal aorta chicken embryos achieve vivo modification. results demonstrated that keratin 75-like 4 (KRT75L4), a candidate gene crucial for feather development, widely knocked out, an 8bp deletion...
Pullorum disease, an intestinal disease in chickens caused by Salmonella enterica serovar pullorum (S. Pullorum), is a significant threat to the poultry industry and results substantial economic losses. The bacteria’s transmission, both vertical horizontal, makes it difficult completely eliminate it. Control strategies for primarily involve stringent eradication programs that cull infected birds employ antibiotics treatment. However, are costly, antibiotic use restricted. Therefore,...
The host and its symbiotic bacteria form a biological entity, holobiont, in which they share dynamic connection characterized by symbiosis, co-metabolism, coevolution. However, how these collaborative relationships were maintained over evolutionary time remains unclear. In this research, the small non-coding RNA (sncRNA) profiles of cecum their contents measured from lines chickens that have undergone long-term selection for high (HWS) or low (LWS) 56-day body weight. results originated...
In mammals, Myostatin (MSTN) is a known negative regulator of muscle growth and development, but its role in birds poorly understood. To investigate the molecular mechanism MSTN on development chickens, we knocked out chicken fetal myoblasts (CFMs) sequenced mRNA transcriptomes. The amplicon sequencing results show that editing efficiency cells was 76%. transcriptomic showed 296 differentially expressed genes were generated after down-regulation MSTN, including angiotensin I converting...
Pigeons serve as important model animals and commercial poultry. The Tarim pigeon, a breed of Columba livia, is locally indigenous unique to China. While the genome C. livia was published in 2013, its assembly fragmented incomplete. In this study, we generated near telomere-to-telomere pigeon using sequencing platform PacBio HiFi, Nanopore long reads Hi-C. assembled spans 1295.8 Mb, with contig N50 size 49 Mb scaffold 85 Mb. Approximately 98.4% anchored onto 41 chromosomes, BUSCO assessment...
Alectoris chukar (chukar) is the most widespread partridge species in world, adapting well to a variety of ecological settings. Like chickens and other poultries, chukars have been domesticated recent decades provide meat eggs. Here we sequenced assembled high-quality, phased-resolved genome, composed 31 pairs relatively complete diploid chromosomes. Genome resequencing population genomic analyses five wild subspecies one domestic insights into domestication, structure, adaptive evolution....