Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by dismal prognosis. Treatment outcomes exhibit substantial variability across patients, underscoring the urgent need for robust predictive models to effectively estimate survival probabilities and therapeutic responses in PDAC. Metabolic immune-related genes exhibiting differential expression were identified using TCGA-PDAC GTEx datasets. A genetic prognostic model was developed via univariable Cox...

Abstract It is necessary to develop prognostic tools of metastatic pancreatic cancer ( MPC ) for optimizing therapeutic strategies. Thus, we tried and validate a nomogram . Data from 3 clinical trials (NCT00844649, NCT01124786, NCT00574275) 133 Chinese patients were used analysis. The former 2 taken as the training cohort while NCT00574275 was validation cohort. In addition, treated in China testing Cox regression model investigate factors With these factors, established verified it by...

Background: Abnormal expression of circular RNA (circRNA) has been shown to play an important role in the progression cancer. However, circRNAs on nonsmall cell lung cancer (NSCLC) remains largely unknown. This study aims reveal effects and potential mechanisms circRNA NSCLC proliferation apoptosis. Materials Methods: Real-time quantitative polymerase chain reaction was used detect circ_0014130 tissues cells. After silencing cells H1299 A549, MTT assay or flow cytometry performed analyze...

Abstract Naïve and memory T cells play a pivotal role in solid tumor pathogenesis but their pancreatic cancer progression remains elusive. Thus, we aimed to investigate clinical potential advanced (APC). Flow cytometry was performed evaluate the level of baseline peripheral naïve from 137 APC patients before receiving first‐line chemotherapy. Interrelationships between naïve, clinicopathological variables were evaluated using Pearson’s correlation. The prognostic impact assessed by...

Background: There is limited consensus on whether metastatic patterns are correlated with prognosis and treatment efficacy in pancreatic cancer.A better understanding of clinical implication the pivotal for therapeutic decision-making drug development.Methods: This study included 977 patients cancer (MPC) three cohorts.The training cohort 273 from trial NCT00574275 367 NCT01124786.As validation cohort, 337 Changzhou No.2 People's Hospital Shanghai General were enrolled.The correlations...

To investigate the inhibitory effect of LNCNA-NEA1 on pancreatic cancer development and progression via spongiosa miR-146b-5p/TRAF6, 60 patients diagnosed from December 2017 to 2019 were selected as a general source information. Real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR) was used detect expression level NEAT1 in cancerous adjacent non-cancerous tissues. Cell counting kit-8 (CCK-8) transwell determine proliferation migration cells (Panc-1). The results dual...

Abstract Background Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of carcinomas. Clinicopathological features this remain obscure, especially in Chinese patients. Therefore, we collected EBV-GCLS cases and studied clinicopathology prognosis. Methods By retrospective review 595 consecutive radical gastrectomies for from 2006 to 2018, identified 8 (1.3%, 8/595) cases. Clinicopathologic characteristics were compared between EBV-GCLSs 109...

Gemcitabine is regarded as a standard medication for patients with pancreatic cancer. The aim of the present study was to investigate impact aspirin (ASA) on efficacy gemcitabine in cancer and potential mechanism. SW1990 BxPC‑3 human cell lines were treated 2 mmol/l ASA and/or 1 mg/l gemcitabine. effects treatments tested viability, migration invasion cells using MTT, wound healing Transwell assays. In addition, apoptosis evaluated via flow cytometry Annexin V‑FITC/PI western blotting Bax...

Objective:The purpose of this study was to evaluate the prognostic value computed tomography (CT) texture features pancreatic cancer with liver metastases.Methods: We included 39 patients metastatic (MPC) metastases and performed analysis on primary tumors metastases.The correlations between parameters were assessed using Pearson's correlation.Univariate Cox proportional hazards model used assess clinicopathological characteristics, overall survival (OS).The univariate regression revealed...

The aim of the present study was to detect expression resistin in rats with acute pancreatitis (AP) and investigate its significance pathogenesis AP. In total, 40 Sprague‑Dawley were randomly divided into four groups (n=10), including normal control, sham‑operated, edematous (AEP) necrotizing (ANP) groups. Following establishment animal models, levels serum resistin, C‑reactive protein (CRP), tumor necrosis factor‑α (TNF‑α) interleukin (IL)‑1β measured using ELISA. Resistin pancreatic...

Papillary early gastric carcinoma (EGC) is believed to have a low risk of lymph node metastasis (LNM) and thus can be resected endoscopically. We observed anecdotally that some papillary EGC tumors showed conspicuous high-grade dysplastic features, but the significance these observations unknown. In this bicenter study we investigated EGCs were divided into (n=96) low-grade (n=118) groups among 1136 consecutive radical resection cases. Concurrent 464 well-moderately differentiated tubular...

Emerging evidence revealed the critical role of systematic inflammation in pancreatic ductal adenocarcinoma (PDAC).In present study, we reviewed records 279 patients with advanced PDAC.Among them, 147 cases were used as training cohort and another 132 validation cohort.In cohort, distant metastasis, carbohydrate antigen 19-9 (CA19-9), Glasgow prognostic score (GPS), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR) independent factors Cox regression.A nomogram based on these...

Abstract Purpose Colon cancer is one of the malignant tumors that threatens human health. miR-510 was demonstrated to play roles in progression various cancers; its dysregulation speculated be associated with development colon cancer. Methods One hundred and thirteen patients participated this research. With help RT-qPCR, expression collected tissues cultured cells analyzed. The association between level clinical features prognosis evaluated. Moreover, effects on cell proliferation,...

Abstract Background: Gemcitabine is considered a classical agent for the treatment of patients with pancreatic cancer. However, gemcitabine resistance common cause failure, leading to poor survival. Therapy overcome would benefit This study investigated impact aspirin (ASA) in biological function cancer cells and potential mechanism. Methods: The MTT assay, wound healing assay annexin V-FITC/PI test was used determine whether ASA could inhibit cells. Besides, expression Bcl-2, Bax,...

Objective To investigate the expression of resistin in rats acute pancreatitis and relationship between its pancreatic pathologic changes. Methods Forty Sprague-Dawlev were randomly divided into four groups:control group,sham operation group,AEP group ANP group. AEP model was induced by intraperitoneal injection cerulein bv intrapefitoneal L-arginine while control received no treatment,and sham grouD rleceived same volume injections 0.9%saline solution.The serum amylase,C-reactive...

Objective To study the role and mechanism of resisitin in prophylactic therapeutic treatments rosiglitazone,a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand,in rats with severe acute pancreatitis (SAP) pancreatitis-associated pulmonary injury.Methods The levels amylase ( AMY ),Resistin,TNF-α,IL-1 β C reactive protein (CRP) blood plasma,lung myeloperoxidase MPO ) activity,pancreas/body weight ratio lung wet/dry were evaluated.Pancreatic pathology observed.The expression...

237 Background: There is a need for prognostic tools in metastatic pancreatic cancer (MPC) because they have the potential to optimize patients’ selection clinical trail and guide treatment strategies. We address this issue by developing validating nomogram with open data. Methods: Data from comparator arm of three trails (NCT00844649, NCT01124786 NCT00574275) MPC treated gemcitabine as first-line chemotherapy were analyzed. The former two taken training cohort while NCT00574275 was used...

e16220 Background: It is necessary to develop prognostic tools of metastatic pancreatic cancer (MPC) for optimizing therapeutic strategies. Thus, we try a nomogram and use it in clinical practice. Methods: Data from trials (NCT00844649, NCT01124786 NCT00574275) MPC patients Changzhou No.2 People’s Hospital was used analysis. The former two were taken as training cohort, the third validation cohort 80 seen test cohort. Cox regression search factors We established with these verified by...