Leisure sedentary behaviors are associated with an increased risk of chronic obstructive pulmonary disease (COPD), but whether this relationship is causal remains unknown. This study aimed to identify genetic determinants leisure and estimate their potential effect on COPD risk. case-control data were obtained from the Finnish biobank. Genome wide association analyses television watching, computer use, driving behavior in UK Biobank 110, 82 6 loci (P ＜ 5 × 10-8), respectively. A 2-sample...

Gastric glomus tumors (GGTs) are rare mesenchymal tumors. Most occur in the distal parts of extremities. Here, we retrospectively analyzed features GGTs from two institutions. The histologic and clinical findings all GGT cases 2009 to 2018 were reviewed. most common location was antrum, mean age patients 49.3 years, tumor size 2.1 cm. Microscopically, small, round cell nodules surrounded expansion blood vessels a nest pattern. Immunohistochemical assays for vimentin smooth muscle actin (SMA)...

Compared with early gastric intramucosal carcinoma, submucosal carcinoma is known to have a higher risk for lymph node metastasis (LMN), but factors in remain elusive. In this multicenter study 621 radical gastrectomies we investigated tumor budding and other of LMN that were identified 172 cases (27.7%). Overall, independent high-risk included lymphovascular invasion (odds ratio, 3.9; 95% confidence interval, 2.5-6.1), 3.3; 1.9-5.9), mixed tubular/papillary adenocarcinoma poorly cohesive...

Abstract Background Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of carcinomas. Clinicopathological features this remain obscure, especially in Chinese patients. Therefore, we collected EBV-GCLS cases and studied clinicopathology prognosis. Methods By retrospective review 595 consecutive radical gastrectomies for from 2006 to 2018, identified 8 (1.3%, 8/595) cases. Clinicopathologic characteristics were compared between EBV-GCLSs 109...

Recently, long noncoding RNAs (lncRNAs) and the Warburg effect have been reported to play important roles in radio-sensitivity of tumor cells. Survival correlates with pathologic responses chemoradiotherapy improving radiation may translate into improved survival. This study aims examine effects mechanisms lncRNA DGCR5 on ESCC cell radiosensitivity. Levels DGCR5, miR-195 hexokinase 2 (HK2) expression tissues cells were determined their clinical significance was analyzed. TE-1 KYSE150...

We followed The Cancer Genome Atlas (TCGA) grouping criteria and conducted a clinicopathological cohort study in unique patient population to gain insight into the pathobiology of esophageal adenocarcinoma (EAC) gastroesophageal junction (AGEJ).We studied statistically compared prognostic features both cancers 303 consecutive patients treated at Veterans Affairs Boston Healthcare System over 20-year period using uniform standardized routines.Over 99% were white men with mean age 69.1 years...

Early adenocarcinoma mixed with a neuroendocrine carcinoma (NEC) component arising in the gastroesophageal junctional (GEJ) region is rare and even rarer young patients. Here, we report such case 29-year-old Chinese man.

Differences in risk factors (RF) of lymph node metastasis (LNM) and prognosis between submucosal early gastric cardiac (SEGCC) noncardiac (SEGNCC) carcinomas remain unclear. In this study, we investigated compared RF LNM 891 patients with radical gastrectomy for SEGCC (n=217) or SEGNCC (n=674). Compared SEGNCC, displayed significantly higher proportion elderly (70 y above), the elevated macroscopic type, well/moderately differentiated tubular low-grade papillary adenocarcinomas, as well...

Papillary early gastric carcinoma (EGC) is believed to have a low risk of lymph node metastasis (LNM) and thus can be resected endoscopically. We observed anecdotally that some papillary EGC tumors showed conspicuous high-grade dysplastic features, but the significance these observations unknown. In this bicenter study we investigated EGCs were divided into (n=96) low-grade (n=118) groups among 1136 consecutive radical resection cases. Concurrent 464 well-moderately differentiated tubular...

Crohn's disease (CD) is a chronic nonspecific intestinal inflammatory disease. The aetiology and pathogenesis of CD are still unclear. Anal fistula the main complication difficult problem to solve at present. limitation developing new therapies bound up with short preclinical security effectiveness data. Therefore, an ideal animal model needed establish persistent anal inflamed rectal mucosa.To improve induction method colitis reliable reproducible perianal fistulizing evaluate treatment...

Aims Alpha‐fetoprotein (AFP)‐producing colorectal adenocarcinoma (AFPCRA) is uncommon, with obscure clinicopathological features and prognosis. Methods Results In this retrospective comparison study on surgically resected adenocarcinomas (CRA, n = 2389), we investigated compared prognostic between AFPCRA cases elevated pre‐operative serum AFP levels, as the group ( 49, 2.1%), exact sex‐, age‐ stage‐matched CRA control at a 1:2 ratio during period from 2011 to 2021. The was further divided...

To investigate the clinicopathological and immunohistochemical features as well diagnosis, differential diagnosis,treatment prognosis of patients with primary renal non-hodgkin's lymphoma (PRNHL).Clinical data 2 PRNHL from January 2013 to October 2017 were retrospectively analyzed.One two male aged 51 years old, admitted hospital for swelling pain in right waist, B-ultra sonic examination showed a very solid upper space occupying lesion. CT soft tissue mass kidney about 10.5 cmx 8.6 cm....

In early gastric cancer (EGC) patients, lymph node metastasis (LNM) risk assessment is particularly important for the selection of surgical methods.In this study, we investigated correlation between gastritis cystica profunda (GCP) and LNM in EGC.From January 2014 to December 2019, EGC patients who underwent curative radical gastrectomy were enrolled study.The clinicopathological features analyzed, GCP was assessed.Data 180 17.8% (32/180) had LNM.The incidence 2.6% GCP-positive group 21.8%...

Introduction: Esophageal adenocarcinoma (EAC) and of the gastroesophageal junction (AGEJ) are often grouped together treated similarly. While there exists notable heterogeneity in their oncogenic profiles, it remains unclear whether they possess distinct clinical presenting symptoms. To close this knowledge gap, after recent pilot data, we now present results entire study cohort comparing symptoms between AGEJ EAC at diagnosis. Methods: This is a retrospective patients with proven cancers...

Introduction: Esophagogastric adenocarcinoma (EGA) includes esophageal (EA), gastroesophageal junctional (GEJA), and distal gastric (DGA) adenocarcinomas. Prognostic significance of clinicopathologic factors in those tumors remain obscure, especially for GEJA that has been inconsistently classified staged. The aim this study was therefore to determine prognostic features EGA 3 geographic tumor groups a large single center cohort. Methods: This is retrospective patients with proven treated...

Objective To investigate the clinicopathological features of early gastric cancer (EGC) with micropapillary pattern. Methods In 447 consecutive EGC patients at Changzhou No.2 People′s Hospital admitted from January 2006 to December 2016, 8 (1.8%) adenocarcinoma (≥5%) were enrolled in observation group and remaining 439 included control group. Clinicopathologic including age, gender, gross pattern, tumor location, size, invasion depth, lymphovascular invasion, lymphatic metastasis...