A5112131012- Genetic and phenotypic traits in livestock
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Pneumonia and Respiratory Infections
- Cancer Immunotherapy and Biomarkers
- Respiratory viral infections research
- Genetic Mapping and Diversity in Plants and Animals
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Phenothiazines and Benzothiazines Synthesis and Activities
- Polysaccharides and Plant Cell Walls
- Lung Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Catalytic Cross-Coupling Reactions
- Cancer-related molecular mechanisms research
- Surface Modification and Superhydrophobicity
- Lung Cancer Research Studies
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Tryptophan and brain disorders
- Galectins and Cancer Biology
- Mobile Crowdsensing and Crowdsourcing
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
Changzhou No.2 People's Hospital
2018-2025
Nanjing Medical University
2018-2025
Nanjing Traditional Chinese Medicine Hospital
2025
Qingdao University
2021-2022
Jiangsu Province Hospital
2022
Nanfang Hospital
2015-2021
Southern Medical University
2015-2021
South China Agricultural University
2020-2021
Project HOPE
2020
Nanjing University of Aeronautics and Astronautics
2018-2019
In the pro-line of fire: A general and efficient cascade reaction approach to substituted phenothiazines, which relies on controlled sequential CuI/L-proline-catalyzed CS CN bond formations, is described. DMSO=dimethylsulfoxide.
Herein, a unique hierarchically structured composite nanofiber membrane, consisting of zeolitic imidazolate framework-8-embedded polyethersulfone (PES@ZIF8) fiber layer and polysulfonamide/polyethersulfone (PSA/PES) layer, was successfully developed to cope with the complex environments during actual filtration/separation process overcome conflict between high filtration efficiency low air pressure resistance. Due advantages synergistic effect multicomponents bi-layer hierarchical structure,...
Gastric cancer is one of the most common malignancies globally; stem cells (CSCs) are regarded as being at root tumor progression, and there thus a need to identify potential drugs target CSCs. The long non-coding RNA MALAT1 promotes epithelial-mesenchymal transition angiogenesis in colorectal cancer, but it unknown whether affects stemness gastric cells. Here, we found that knockdown (KD) attenuated non-adherent cell spheroids, evidenced by decrease primary secondary spheroid formation...
The loss of ITGA2 plays an important role in cancer metastasis several solid cancers. However, the molecular mechanism primary cancers remains unclear. In this study, we found that a lower protein level was observed breast compared to adjacent non-cancerous tissues. Interestingly, reduction degree at far more than mRNA level. We further showed translation directly inhibited by miR-373 through binding ITGA2-3'UTR. Silencing detached cell-cell interactions, induced deploymerization stress...
Abstract Background In the process of pig breeding, average daily gain (ADG), days to 100 kg (AGE), and backfat thickness (BFT) are directly related growth rate fatness. However, genetic mechanisms involved not well understood. Copy number variation (CNV), an important source diversity, can affect a variety complex traits diseases has gradually been thrust into limelight. this study, we reported genome-wide CNVs Duroc pigs using SNP genotyping data from 6627 animals. We also performed copy...
ABSTRACT Circadian rhythm is a physiological process that oscillates in 24 h cycle. It has complex connection with the function of human immune system and even development tumours. Previous studies demonstrated time‐dependent effects chemotherapy radiotherapy; however, there are few on timing immunotherapy. Here, we explored differences efficacy checkpoint inhibitors (ICIs) administered at different circadian times non‐small cell lung cancer (NSCLC). C57BL/6N Lewis mice models were...
The standard first-line treatment for driver-gene negative advanced non-small cell lung cancer (NSCLC) is chemotherapy combined with immunotherapy. However, owing to the immune microenvironment imbalance and status impairment caused by repeated chemotherapy, as well primary or secondary resistance checkpoint inhibitors, efficacy of immunotherapy remains unsatisfactory. Recent studies have shown that faecal microbiota transplantation (FMT) can modulate intestinal microflora, influence tumour...
Chronic kidney disease (CKD) is a worldwide public health problem, and unfortunately, the therapeutic index of clinically available drugs limited. Thus, there great need to exploit effective treatment strategies, carrier-drug approach an attractive method improve specificity agents. The aim this present study develop peptide-drug conjugate for targeted delivery angiotensin-converting enzyme (ACE) inhibitor captopril (CAP), since G3-C12 peptide (ANTPCGPYTHDCPVKR) could specifically accumulate...
Background Dissemination of antibiotic resistant clones is recognized as an important factor in the emergence and prevalence resistance pneumococcus. This study was undertaken to survey antimicrobial susceptibility serotypes distribution pneumococci explore circulating hospitalized children Suzhou, China. Methods The were isolated from nasopharyngeal aspirates less than 5 years age admitted Soochow-University-Affiliated-Children's-Hospital with respiratory infections. capsular identified by...
Middle school students are recommended as the primary target population for human papillomavirus (HPV) vaccination. This study aimed to assess HPV and vaccine knowledge, evaluate effect of a school-based educational intervention, immediately one year later, on knowledge acceptability among adolescents in mainland China.A interventional follow-up was conducted seven representative cities China from May 2015 2017. "Train-the-trainer" strategy employed educate teachers this study. Students aged...
To determine the lipid content and fatty acid (FA) composition of breast milk from fifty-two lactating women between ninth twelfth lactation weeks in rural North China. The mothers were questioned on their dietary habits. Total lipids extracts transmethylated analysed using GLC to FA contents. mean was 40·21 ( sd 1·43) g/l. SFA constituted 35·92 % total FA. Medium-chain long-chain presented levels 10·91 25·01 %, respectively. MUFA PUFA 32·59 19·97 FA, Oleic, linoleic α-linolenic (ALA)...
Selective syntheses of alkaloids bearing distinct core structures were enabled by chemically programmed polycyclizations using water as a switch.
There are scare data about bacterial etiology and the antibiotic susceptibility, serotype distribution molecular characteristics of pneumococci in children with acute otitis media (AOM) China.A prospective study was conducted Suzhou University Affiliated Children's Hospital. All under 18 years age diagnosed as AOM spontaneous otorrhea were offered enrollment, collection middle ear fluid then cultured for pathogens. The serotypes, macrolide resistance genes sequence types Streptococcus...
Limited information is available on the non-influenza etiology and epidemiology of influenza-like illness (ILI) in China. From April 2011 to March 2014, we collected oropharyngeal swabs from children less than 5 years age with symptoms ILI who presented outpatient departments Suzhou University Affiliated Children's Hospital (SCH). We used reverse transcription polymerase chain reaction (rt-PCR) or PCR detect 11 respiratory viruses. Among 3,662 enrolled patients, 1,292 (35.3%) tested positive...