A5100624910- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- DNA Repair Mechanisms
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Bone Tumor Diagnosis and Treatments
- dental development and anomalies
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone and Dental Protein Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- PARP inhibition in cancer therapy
- Extracellular vesicles in disease
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Soft tissue tumor case studies
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- DNA and Biological Computing
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2025
Aerospace Center Hospital
2025
Xuzhou Medical College
2025
Central South University
2016-2024
Xiangya Hospital Central South University
2017-2024
Massachusetts General Hospital
2020-2024
Harvard University
2020-2024
Hunan Cancer Hospital
2024
National Clinical Research Center for Digestive Diseases
2022
cGAS controls replication dynamics and suppresses replication-associated DNA damage.
Abstract Background Circular RNAs (circRNAs) are widely expressed in human cells and closely associated with cancer development. However, they have rarely been investigated the context of nasopharyngeal carcinoma (NPC). Methods We screened a new circRNA, circRNF13 , NPC using next-generation sequencing mRNA. Reverse transcription polymerase chain reaction RNA fluorescence situ hybridization were used to detect expression 12 non-tumor epithelial (NPE) tissues 36 samples. Cell proliferation...
Abstract Background Circular RNAs play an important role in tumor genesis and progression, but they have not been sufficiently studied patients with nasopharyngeal carcinoma (NPC). Methods The circular RNA, circCAMSAP1, was screened NPC cells by RNA sequencing analysis. expression of circCAMSAP1 tissues examined real-time quantitative polymerase chain reaction (RT-qPCR) situ hybridization. Wound-healing, transwell, MTT flow cytometry assays, nude mouse models were used to explore the effect...
Abstract Background Circular RNAs (circRNAs) act as gene expression regulators and are involved in cancer progression. However, their functions have not been sufficiently investigated nasopharyngeal carcinoma (NPC). Methods The profiles of circRNAs NPC cells within different metastatic potential were reanalyzed. Quantitative reverse transcription PCR situ hybridization used to detect the level circPVT1 tissue samples. association with clinical properties patients was evaluated. Then, effects...
Abstract Background Radiation therapy stands to be one of the primary approaches in clinical treatment malignant tumors. Nasopharyngeal Carcinoma, a malignancy predominantly treated with radiation therapy, provides an invaluable model for investigating mechanisms underlying resistance cancer. While some reports have suggested involvement circRNAs modulating underpinning remain unclear. Methods RT-qPCR and situ hybridization were used detect expression level circCDYL2 nasopharyngeal carcinoma...
Metabolic abnormalities are one of the essential features tumors. Increasingly more studies have shown that lovastatin, a lipid-reducing drug, has visible inhibitory effects on tumors, but it not been reported in nasopharyngeal carcinoma. In this paper, we explored lovastatin growth carcinoma cells and its possible molecular mechanisms. After treating with different concentrations found can inhibit time- dose-dependent manner. To explore mechanism how inhibits carcinoma, examined proteome...
This study aimed to evaluate the efficiency and safety of indocyanine green (ICG) fluorescence real-time imaging-guided technology in laparoscopic hepatectomy. A retrospective analysis patients with primary liver cancer First Affiliated Hospital USTC from January 2018 October 2021, including 48 cases fluorescence-guided hepatectomy (FGLH) 60 traditional (LH), was conducted. R0 resection rate, operation time, intraoperative blood loss, complications, hospital stay, other postoperative...
Runt-related transcription factor 2 (Runx2) is involved in the early stage of tooth development. However, only few studies have reported role Runx2 enamel development, which may be attributed to that full knockout mice cannot survive after birth. In present study, we successfully established a Runx2-deficient mouse model using conditional (cKO) method. We observed significant reduction degree mineralization and decreased size rods cKO mice. Histological analysis showed retained proteins...