A5058605223- Bone and Dental Protein Studies
- dental development and anomalies
- Periodontal Regeneration and Treatments
- Cancer Research and Treatments
- Bone Metabolism and Diseases
- S100 Proteins and Annexins
- NF-κB Signaling Pathways
- Connective tissue disorders research
- Alkaline Phosphatase Research Studies
- Oral microbiology and periodontitis research
- Cell Adhesion Molecules Research
Binzhou University
2018-2022
Binzhou Medical University
2018-2022
Runt-related transcription factor 2 (Runx2) is involved in the early stage of tooth development. However, only few studies have reported role Runx2 enamel development, which may be attributed to that full knockout mice cannot survive after birth. In present study, we successfully established a Runx2-deficient mouse model using conditional (cKO) method. We observed significant reduction degree mineralization and decreased size rods cKO mice. Histological analysis showed retained proteins...
Abstract Background Mutation in Odontogenesis‐associated phosphoprotein (ODAPH) has been reported to cause recessive hypomineralized amelogenesis imperfecta (AI) human. However, the exact role of ODAPH is still unknown. Results was identified as a novel constituent atypical basal lamina located at interface between maturation ameloblasts and enamel by dual immunofluorescence staining LAMC2. Odaph knockout mice were generated explore function amelogenesis. −/− teeth showed severely attrition...
The aim of this investigation was to study the effects Runt-related transcription factor 2 (Runx2) on junctional epithelium and alveolar bone.The attachment level resorption bone were analyzed by histology scanning electron microscopy. expression amelotin determined immunohistochemistry, Western blot, real-time PCR. ultrastructure dentogingival interface observed transmission microscopy.The cKO mice demonstrated remarkable loss, epithelial hyperplasia, loss. relative protein mRNA increased...