Mingzhu Chen

ORCID: 0000-0002-1183-7688
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Research Areas
  • Nanoplatforms for cancer theranostics
  • Advanced Nanomaterials in Catalysis
  • Demographic Trends and Gender Preferences
  • Nanoparticle-Based Drug Delivery
  • Reproductive Health and Technologies
  • Acoustic Wave Resonator Technologies
  • Extracellular vesicles in disease
  • Reproductive Health and Contraception
  • Ferroelectric and Piezoelectric Materials
  • GaN-based semiconductor devices and materials
  • Liver Disease Diagnosis and Treatment
  • Ultrasonics and Acoustic Wave Propagation
  • Hepatitis B Virus Studies
  • Photoacoustic and Ultrasonic Imaging
  • Perovskite Materials and Applications
  • Family Dynamics and Relationships
  • Adolescent Sexual and Reproductive Health
  • Solid-state spectroscopy and crystallography
  • Global Maternal and Child Health
  • Autophagy in Disease and Therapy
  • Liver physiology and pathology
  • Ergonomics and Human Factors
  • Metal and Thin Film Mechanics
  • Laser-Ablation Synthesis of Nanoparticles
  • Engineering Education and Curriculum Development

Wuhan University
2021-2025

Lanzhou University
2024

State Key Laboratory of Applied Organic Chemistry
2024

Nanjing University of Science and Technology
2024

Shanghai Normal University
2021-2023

Quanzhou Normal University
2023

Jiangnan University
2023

Zhongnan Hospital of Wuhan University
2021-2022

China West Normal University
2022

Army Medical University
2022

High doses of radiation can cause serious side effects and efficient radiosensitizers are urgently needed. To overcome this problem, we developed a biomimetic nanozyme system (CF) by coating pyrite (FeS

10.1186/s12951-021-01182-y article EN cc-by Journal of Nanobiotechnology 2021-12-01

Background/Aims: Disrupted bile acid regulation and accumulation in the liver can contribute to progressive damage fibrosis. However, effects of acids on activation hepatic stellate cells (HSCs) remain unclear. This study investigated HSC during fibrosis, examined underlying mechanisms.Methods: The immortalized HSCs, LX-2 JS-1cells were used for vitro study. vitro, adeno-associated viruses virus-sh-S1PR2 JTE-013 pharmacologically inhibit activity S1PR2 a murine model fibrosis induced by...

10.3350/cmh.2022.0327 article EN cc-by-nc Clinical and Molecular Hepatology 2023-02-21

Interstitial brachytherapy (BT) is a promising radiation therapy for cancer; however, the efficacy of BT limited by tumor radioresistance. Recent advances in materials science and nanotechnology have offered many new opportunities BT.

10.7150/thno.61259 article EN cc-by Theranostics 2021-01-01

Sonosensitizer-mediated sonodynamic therapy (SDT) has emerged as a promising anti-tumor strategy. However, this strategy of continuous oxygen consumption further exacerbates the hypoxic tumor microenvironment, which limits its therapeutic efficacy. In study, we designed multifunctional hydrogel (PB+Ce6@Hy) that simultaneously co-delivers nanozyme prussian blue (PB) and sonosensitizer chlorin e6 (Ce6) for realization photothermal (PTT) enhanced SDT. When reaches tissue through local...

10.3389/fonc.2022.888855 article EN cc-by Frontiers in Oncology 2022-07-04

Solution processability is a prominent advantage for the commercial fabrication of perovskite solar cells (PSCs). However, ionic side reactions can cause solutions to age, which greatly limits industrial prospects reproducible production PSCs. Herein, mechanism underlying halogen anion elucidated and an effective scheme managing anions proposed. The oxidation main factor solution aging. addition iodine monobromide (IBr) stabilizes precursor by promoting reverse reaction. Meanwhile, IBr...

10.1002/solr.202301001 article EN Solar RRL 2024-01-31

In this work, we systematically studied the deposition, characterization, and crystal structure modeling of ScAlN thin film. Measurements piezoelectric device's relevant material properties, such as structure, crystallographic orientation, response, were performed to characterize Sc0.29Al0.71N film grown using pulsed DC magnetron sputtering. Crystal is proposed validated, structure-property relations are discussed. The investigation results indicated that sputtered seed layer technique had a...

10.3390/ma14216437 article EN Materials 2021-10-27

Abstract Background Reproductive health is the core science of human life and critical to healthy sustainable development society. Since 1980, China has enforced a “one child” policy. With implementation Universal Two-Child Policy in 2016, every couple allowed have two children instead one, which will lead more pregnancies, births, advanced maternal age. Thus, women aged 20–39 years, at peak sexual activity fertility, face reproductive problems related pregnancies births. This study aimed...

10.1186/s12978-020-00939-2 article EN cc-by Reproductive Health 2020-06-10

Abstract The compelling demand for laser protection both civil and defense use calls new‐generation nonlinear optical materials. Chemical vapor deposition (CVD) techniques provide extra tricks to modulate crystal nonlinearity through fractal growth. synthesized 2D NbSe 2 its structures exhibit giant, broadband attenuation behaviors extending into the near Infrared (NIR) range. Particularly, limiting performance generally correlates with dimension, where Fractal demonstrates enhanced...

10.1002/adfm.202401490 article EN Advanced Functional Materials 2024-04-08

The floating population serves an important role in economic and social development. However, little is known about the population's reproductive health (RH) services, especially low- middle-income countries. This study aimed to assess use of services female China, which a country with largest world.A cross-sectional survey was conducted for more than 3 months. Six hundred twenty females childbearing age were recruited into by using random sampling, these individuals being from six community...

10.1186/s12913-019-4334-4 article EN cc-by BMC Health Services Research 2019-08-01

Abstract In this paper, we present hetero acoustic layer (HAL) structures based on ScAlN thin films with a c -axis tilt angle. The surface wave (SAW) excitation modes and their propagation characteristics for different Euler angles (0°, θ , ψ ) of the film are analyzed using finite element method. We find that field distribution HAL can be adjusted by rotating normal SAWs suppressed; however, leaky (LSAWs) significantly improved electromechanical coupling coefficients ( K 2 excited. A...

10.35848/1347-4065/abdc35 article EN Japanese Journal of Applied Physics 2021-01-16

This paper presents a Piezoelectric micromechanical ultrasonic transducer (PMUT) based on Pt/ScAlN/Mo/SiO2/Si/SiO2/Si multilayer structure with circular suspension film of scandium doped aluminum nitride (ScAlN). Multiphysics modeling using the finite element method and analysis effect different Sc doping concentrations resonant frequency, effective electromechanical coupling coefficient (keff2) station sensitivity PMUT cell are performed. The calculation results show that frequency...

10.3390/mi14101942 article EN cc-by Micromachines 2023-10-18

Disulfiram (DSF) is an important drug for the treatment and management of alcohol dependency. This has been approved by US-FDA, its activity against tumor dependent on copper ion (Cu2+). However, toxicity (caused via external copper) intrinsic anfractuous distribution in human body have adversely suppressed mechanism DSF vivo. In this study, we aimed to design injectable hydrogel, as CRC (Cu2+ release controller) effective tumors. The hydrogels agarose used wrapping CuCl2, hierarchical...

10.3390/life11050391 article EN cc-by Life 2021-04-26

Boosting the stability of cesium/formamidinium (Cs/FA) based perovskite solar cells (PSCs) has received tremendous attention. However, crystallization perovskites usually undergoes complex intermediate phase transitions and ion loss processes, which seriously degrade efficiency PSCs. Herein, iodine monobromide (IBr, an interhalogen) is incorporated into precursor solution to regulate process. IBr can directly induce formation crystal nuclei in film, avoiding a transformation (2H-4H-3C). This...

10.1021/acsami.4c16316 article EN ACS Applied Materials & Interfaces 2024-12-23

Continuous high doses of radiation can cause irreversible side effects and resistance; thus, advanced radiosensitizers are urgently needed. To overcome this problem, we developed a nano platelet radiosensitization system (PCA) by coating the chemotherapeutic drug cisplatin (CDDP) loaded gold nanocages (AuNs) within membrane. The PCA may enable AuNs to have immune escape targeting capabilities. After administration, will actively target tumor cells avoid being cleared system. Subsequently,...

10.3389/fonc.2021.793006 article EN cc-by Frontiers in Oncology 2021-11-24

The alkyl radical trigger AIPH and nanozyme pyrite were encapsulated in agarose hydrogel to prepare the AIPH–FeS 2 –hydrogel system. Pyrite can be used as a photothermal agent an oxidative stress amplifier, boosting therapeutic effect of radicals.

10.1039/d2na00395c article EN cc-by-nc Nanoscale Advances 2022-01-01

Type I photosensitizers with aggregation-induced emission luminogens (AIE-gens) have the ability to generate high levels of reactive oxygen species (ROS), which a good application prospect in cancer photodynamic therapy (PDT). However, encapsulation and delivery AIE molecules are unsatisfactory seriously affect efficiency practical therapy. Faced this issue, we synthesized metal-organic framework (MOF) one step using microfluidic integration technology encapsulated TBP-2 (an molecule) into...

10.3390/molecules27238386 article EN cc-by Molecules 2022-12-01

The importance of the online travel search environment is well documented. In this context, trademarks play an instrumental role in resolving customer confusion environment. An important element organic output that typically displayed on left side results screen major engines. This study evaluated listing performance a U.S.-based context hotel (websites) three engines (Google, Yahoo! and MSN [later Bing]) across four countries (United States, United Kingdom, China, India) over two separate...

10.1177/0047287511400612 article EN Journal of Travel Research 2011-03-11

Abstract Background Fertility knowledge is vital to the fertility health of young people and greatly impacts their choices. Delayed childbearing has been increasing in high-income countries, accompanied by risk involuntary childlessness or having fewer children than desired. The aim this study was investigate about issues, related influencing factors, method acquiring knowledge, relationship between intentions among college students. Methods An online cross-sectional survey Chinese students...

10.1186/s12889-020-08937-6 article EN cc-by BMC Public Health 2020-05-29

Copper chalcogenide nanocrystal is a promising photothermal transduction material for photoacoustic imaging and therapy. But how to ameliorate its conversion efficiency in controllable manner still not well understood. Here, novel gold-promoting-satellite Cu2-xSe (GPS–CS) nanoparticle was developed by simple situ reduction. Our simulated models indicated that maintaining the number of gold satellites at ∼10 per can significantly boost efficiency. The GPS-CS exhibited higher less toxicity...

10.1016/j.mtnano.2022.100211 article EN cc-by-nc-nd Materials Today Nano 2022-05-01

<title>Abstract</title> Background: Fertility knowledge is vital to the fertility health of young people and greatly impacts their choices. Delayed childbearing has been increasing in high-income countries, accompanied by risk involuntary childlessness or having fewer children than desired. The aim this study was investigate about issues, related influencing factors, method acquiring knowledge, relationship between intentions among college students. Methods: An online cross-sectional survey...

10.21203/rs.2.16013/v3 preprint EN Research Square (Research Square) 2020-04-09
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